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  1. 88921
    “…Taken together, our studies illustrate how aberrant CpG island hypermethylation in CIMP-high ACC participates in a targetable repressive epigenetic cascade that reinforces oncogenic adrenocortical transcriptional programs. …”
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    SAT-LB34 Repressive Epigenetic Programs Reinforce Steroidogenic Differentiation and Wnt/β-Catenin Signaling in Aggressive Adrenocortical Carcinoma
  2. 88922
    “…Although DAA and genetic testing can be costly, diagnosis can dramatically alter diabetes management as illustrated in all 4 cases, and overall cost of management may be lower in the end. …”
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    MON-057 MODY Diagnosis: Missed Opportunity to Avert Insulin Therapy. A Case Series
  3. 88923
    “…DISCUSSION: Both cases illustrate different presentations of hepatotoxicity by clozapine. …”
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    M200. CLOZAPINE-INDUCED HEPATOTOXICITY: TWO CASE REPORTS
  4. 88924
    “…Alterations of gross brain anatomy are relatively late events but early and subtle neurochemical changes and especially those reflecting oxidative stress and concomitant synaptic remodeling are promising candidates. This pilot study illustrates the potential of three-dimension MRSI to detect such alterations in the whole brain and with a good spatial resolution.…”
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    T160. HIGH-RESOLUTION WHOLE BRAIN MR SPECTROSCOPIC IMAGING IN YOUTHS AT CLINICAL HIGH RISK FOR PSYCHOSIS: A PILOT STUDY
  5. 88925
    “…In order to encourage the embedding of microbiology‐centric class excursions in current curricula, we suggest and illustrate here some possibilities relating to the topics of food (a favourite pre‐occupation of most children), agriculture (together with horticulture and aquaculture), health and medicine, the environment and biotechnology. …”
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    Visualizing the invisible: class excursions to ignite children’s enthusiasm for microbes
  6. 88926
    “…For telephone interviews, the question of the sound envelope is central, in particular regarding the psychic function of silence. We choose to illustrate our point with short vignettes than by relying on long-term clinical cases, more likely to represent the variety of new clinical situations encountered and the questions that accompany them. …”
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    Séances par téléphone dans le contexte du Covid-19 : le cadre et ses limites
  7. 88927
    “…RESULTS: We determined the genomic distribution of histone variants H1.2 and H1.5 in human myeloid leukemia cells HL-60/S4 and compared their epitope exposure by both xChIP-seq and xxChIP-seq, as well as high-resolution microscopy, illustrating the influences of preserved chromatin higher-order structure in situ. …”
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    Linker histone epitopes are hidden by in situ higher-order chromatin structure
  8. 88928
    “…CMO configurations were drafted, based on the relevant literature, which serve as exemplars to illustrate how this methodology could be used. In order to debate, test and expand our hypothesized programme theory for collaborative practice with parents, further testing against a broader literature is required alongside research to explore the functionality of the configurations across contexts. …”
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    Collaboration between parents and SLTs produces optimal outcomes for children attending speech and language therapy: Gathering the evidence
  9. 88929
    “…This information should be offered during preoperative counseling to illustrate the potential risk of delayed surgery in active patients with acute ACL rupture.…”
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    Delaying ACL Reconstruction Beyond 6 months from Injury Impacts Likelihood for Clinically Significant Outcome Improvement
  10. 88930
    “…However, the underlying mechanisms of miR-145 in tumor angiogenesis of UM are still not well illustrated. Thus, we aimed to explore the potential target genes or pathways regulated by miR-145 in UM and the effect of miR-145 on invasion and angiogenesis. …”
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    MicroRNA-145 suppresses uveal melanoma angiogenesis and growth by targeting neuroblastoma RAS viral oncogene homolog and vascular endothelial growth factor
  11. 88931
    “…Bland-Altman plots illustrated nonsystematic bias and small limits of agreement for Fitbit One and Jawbone UP2. …”
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    Formative Evaluation of Consumer-Grade Activity Monitors Worn by Older Adults: Test-Retest Reliability and Criterion Validity of Step Counts
  12. 88932
    “…We also present case studies to illustrate the points being made throughout. LIMITATIONS: The framework aims to help research teams prioritise research questions and design and conduct research with an appropriate choice of methods, rather than to provide detailed guidance on the use of specific methods. …”
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    Framework for the development and evaluation of complex interventions: gap analysis, workshop and consultation-informed update
  13. 88933
    “…CONCLUSIONS: We demonstrated that our population pharmacokinetic model was able to accurately and precisely predict future everolimus exposure from prior pharmacokinetic measurements. In addition, we illustrated the potential added value of performing everolimus therapeutic drug monitoring with haematocrit-normalised whole-blood concentrations. …”
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    Model-Informed Precision Dosing of Everolimus: External Validation in Adult Renal Transplant Recipients
  14. 88934
    “…CONCLUSIONS: Present study enlightens on the detailed characteristics of cocoonase and sericin proteins, comparative degumming activity, and image analysis of cocoonase enzyme and Na(2)CO(3) chemical-treated silk sheets. Obtained findings illustrated about use of cocoonase enzyme in the degumming of silk cocoon at larger scale that will be a boon to the silk industry. …”
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    Study on cocoonase, sericin, and degumming of silk cocoon: computational and experimental
  15. 88935
    “…The receiver operating characteristic (ROC) analysis illustrated that the area under the curve was 0.80 (95% confidence interval [CI] 0.71–0.89; P < 0.001) and the optimal cut-off value of serum O-sulfotyrosine suggesting AKI was < 147.40 ng/mL with a sensitivity and specificity of 80.90 and 70.00% respectively. …”
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    Using circulating O-sulfotyrosine in the differential diagnosis of acute kidney injury and chronic kidney disease
  16. 88936
    “…The brain/plasma concentration ratio of 0.42 (543.56/1295.66) was used to illustrate the penetration power through the BBB after the multiple doses for 28 days. …”
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    Repurposing of Omarigliptin as a Neuroprotective Agent Based on Docking with A(2A) Adenosine and AChE Receptors, Brain GLP-1 Response and Its Brain/Plasma Concentration Ratio after 28 Days Multiple Doses in Rats Using LC-MS/MS
  17. 88937
    “…These effects persisted beyond S38844 administration, illustrated by the improvements in cardiac output (130 ± 6 mL/min; P < 0.05), myocardial tissue perfusion (6.38 ± 0.48 mL/min/g; P < 0.01), and coronary relaxation (71 ± 4%; P < 0.01) at Day 14. …”
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    Transient heart rate reduction improves acute decompensated heart failure‐induced left ventricular and coronary dysfunction
  18. 88938
    “…In summary, this case illustrates the nephrotoxicity of NA and importance of multi-disciplinary care as the side effect can be multi-systemic.…”
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    Fanconi’s Syndrome and Dementia in a Patient With Chronic Hepatitis B Taking Nucleoside/ Nucleotide Analogue
  19. 88939
    “…Conclusion: This case illustrates aggressive nature of SCAs with higher risk of recurrence compared to other non-functioning adenomas and therefore requires close follow up.…”
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    A Case of Silent Corticotroph Adenoma
  20. 88940
    “…For patients with above-target HbA1c , the results indicate a relatively large glycemic burden and clinical inertia towards treatment intensification. The findings illustrate some limitations associated with treatment of T2D with oral GLAs. …”
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    Time to Failure on Oral Glucose-Lowering Agents for Patients with Type 2 Diabetes: A Retrospective Cohort Study
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