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  1. 328881
    “…RESULTS: The genetic stability of the sex-linked fluorescent marker and the integrity and high level of sexing efficiency of the system were confirmed. …”
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    Life-history traits of a fluorescent Anopheles arabiensis genetic sexing strain introgressed into South African genomic background
  2. 328882
    por Lin, Shaofu, Shi, Chengyu, Chen, Jianhui
    Publicado 2022
    “…CONCLUSIONS: The advantages of our model are mainly attributed to two kinds of pre-training tasks and the multi-task learning framework, which can learn richer structural information of proteins and drugs from large-scale unlabeled data, and then effectively integrate it into the downstream prediction task for obtaining a high-quality DTA prediction in unknown drug discovery.…”
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    GeneralizedDTA: combining pre-training and multi-task learning to predict drug-target binding affinity for unknown drug discovery
  3. 328883
    “…BACKGROUND: Achilles tendinopathy (AT) may affect ground reaction force (GRF) and muscle synergy (MS) during walking due to pain, biological integrity changes in the tendon and neuroplastic adaptations. …”
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    Unilateral symptomatic Achilles tendinopathy has limited effects on bilateral lower limb ground reaction force asymmetries and muscular synergy attributes when walking at natural and fast speeds
  4. 328884
    “…Model parameters were estimated using Integrated Nested Laplace Approximation (INLA). Deviance Information Criterion (DIC) and Conditional Predictive Ordinate (CPO) were computed to assess model fit. …”
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    Variation in smoking attributable all-cause mortality across municipalities in Belgium, 2018: application of a Bayesian approach for small area estimations
  5. 328885
    “…These findings call for programmes of integrated care to consider sex-specific differences to ensure men and women are served equally. …”
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    Sex-specific patterns and lifetime risk of multimorbidity in the general population: a 23-year prospective cohort study
  6. 328886
    “…Using modern statistical methods, 463 metabolite–lipid, 62 trait–metabolite, and 89 trait–lipid associations were found to be significant. Integrating these associations into the above networks, an MDGN was constructed, and 128 sub-networks were extracted. …”
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    4D genetic networks reveal the genetic basis of metabolites and seed oil-related traits in 398 soybean RILs
  7. 328887
    “…Enhanced REP will tailor the intervention and training to integrate trauma-informed approaches and deploy customized implementation support (i.e., facilitation). …”
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    Michigan Model for Health(TM) Learning to Enhance and Adapt for Prevention (Mi-LEAP): protocol of a pilot randomized trial comparing Enhanced Replicating Effective Programs versus standard implementation to deliver an evidence-based drug use prevention curriculum
  8. 328888
    “…CONCLUSIONS: These findings show pain intensity is an integral part of disease activity, though it is not measured directly in DAS28-ESR. …”
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    Defining the relationship between pain intensity and disease activity in patients with rheumatoid arthritis: a secondary analysis of six studies
  9. 328889
    “…We call for urgent integrated nutrition and caregiving interventions, especially as interventions for child development are lacking in Nepal. …”
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    Feeding, caregiving practices, and developmental delay among children under five in lowland Nepal: a community-based cross-sectional survey
  10. 328890
    “…The majority considered pharmacists as an integral part of the healthcare system (98.7% - 375/380) and experts in medication (84.7% - 322/380). …”
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    Gaps in expectations and current practices of pharmacy services among doctors and patients – an exploratory study in a Sri Lankan tertiary care hospital providing free healthcare
  11. 328891
    “…The analyses in non-transformed fibroblasts show that AKTIP mislocalizes in HGPS cells but not in EDMD2. The integrated analysis of lamin expression, nuclear morphology, and AKTIP topology shows that positioning of AKTIP is influenced not only by lamin expression, but also by nuclear morphology. …”
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    Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP
  12. 328892
    “…METHODS: A retrospective analysis was conducted using Optum’s de-identified Integrated Claims-Clinical data set with Enriched Oncology, which includes data from Medicare Advantage and commercially insured members. …”
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    Increased healthcare costs by later stage cancer diagnosis
  13. 328893
    “…We applied interrupted autoregressive integrated moving average models to examine weekly patterns of prescription opioids before and during the pandemic (starting at the lockdown). …”
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    Impact of the COVID-19 Pandemic on Patterns of Prescription Opioid Use: A Retrospective Cohort Study of Adults Without a Cancer Diagnosis Initiating Opioids Using Administrative Claims Data
  14. 328894
    “…In comparison with these scores, the integrated discrimination improvement and decision curve analysis showed improved accuracy in predicting SAP and better net benefits for clinical decisions. …”
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    Development and validation of a risk prediction score for the severity of acute hypertriglyceridemic pancreatitis in Chinese patients
  15. 328895
    “…This study identified a need to develop guidelines that consider NCDs holistically, with an integrated approach to antenatal, intrapartum, and postnatal care, and that are relevant for resource-limited contexts. …”
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    Prevention and control of non-communicable diseases in antenatal, intrapartum, and postnatal care: a systematic scoping review of clinical practice guidelines since 2011
  16. 328896
    “…Recently, with the emergence of 12 novel RM Y-STRs, an integrated panel named RMplex was introduced, which contains all 26 RM Y-STRs and four fast mutating Y-STRs (FM Y-STRs). …”
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    Mutation analysis for newly suggested 30 Y-STR loci with high mutation rates in Chinese father-son pairs
  17. 328897
    “…The current study assesses the association of three types of MSM-related sexual behavior-related stigma (family, healthcare, general social stigma) measured at both individual and site levels and the presence/absence of laws criminalizing HIV transmission with HIV testing behaviors to inform HIV surveillance and prevention efforts among HIV-negative MSM in a holistic and integrated way. METHODS: We included nine National HIV Behavioral Surveillance (NHBS) 2017 sites: Baltimore, MD; Denver, CO; Detroit, MI; Houston, TX; Long Island/Nassau-Suffolk, NY; Los Angeles, CA; Portland, OR; San Diego, CA; and Virginia Beach and Norfolk, VA. …”
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    Associations between HIV testing and multilevel stigmas among gay men and other men who have sex with men in nine urban centers across the United States
  18. 328898
    “…This paper reports stages of development of the integrated app and results of the usability testing. …”
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    Tough Talks Virtual Simulation HIV Disclosure Intervention for Young Men Who Have Sex With Men: Development and Usability Testing
  19. 328899
    “…Functional enrichment analysis, using the identified changes in methylation and gene expression as input, revealed enrichment in disease ontologies related to diabetes, carbohydrate and glucose metabolism, pathways including MAPK1/MAPK3 and MAPK family signaling, and genes related to T1DM, obesity, atherosclerosis, and vascular pathologies. Lastly, by integrating the DNA methylation and RNA expression data, we identified six genes where relevant methylation changes corresponded with RNA expression (CIITA, TPM1, PXN, ST8SIA1, LIPA, DAXX). …”
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    Epigenetic and transcriptomic alterations in offspring born to women with type 1 diabetes (the EPICOM study)
  20. 328900
    “…Previous experience with the software and an easy integration into daily practice were considered to be crucial utilisation drivers. …”
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    Health care professionals’ perspectives on the utilisation of a remote surveillance and care tool for patients with COVID-19 in general practice: a qualitative study
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