“…The Sm-Barbier reaction is similar to the traditional Grignard reaction with the only difference being that the alkyl halide, carbonyl, and Sm reductant are mixed simultaneously in one pot.(1,15) Examples of Sm-mediated Barbier reactions with a range of coupling partners have been reported,(1,3,7,10,12) and have been utilized in key steps of the synthesis of large natural products.(16,17) Previous studies on the effect of additives on SmI(2) reactions have shown that HMPA enhances the reduction potential of SmI(2) by coordinating to the samarium metal center, producing a more powerful,(13-14,18) sterically encumbered reductant(19-21) and in some cases playing an integral role in post electron-transfer steps facilitating subsequent bond-forming events.(22) In the Sm-Barbier reaction, HMPA has been shown to additionally activate the alkyl halide by forming a complex in a pre-equilibrium step.(23) Ni(II) salts are a catalytic additive used frequently in Sm-mediated transformations.(24-27) Though critical for success, the mechanistic role of Ni(II) was not known in these reactions. …”
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“…The cells appeared viable, integrated and were found in clusters or in the interstitial-spaces. …”
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“…INTERPRETATION: Our results support strategies to integrate cash transfers into social welfare programming in sub-Saharan Africa, but further evidence is needed for the comparative effectiveness of UCT and CCT programmes in this region. …”
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“…This research provides an integral step toward better understanding the social and organizational context and impact of PHR and secure messaging use in clinical practice settings.…”
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“…Data on zoonotic viruses varied across agencies presenting challenges for researchers needing to integrate animal and human data from different websites.…”
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“…Very little is known about the number of children living within any given geographical locality, costs of care, or experiences of children with ongoing palliative care needs and their families. We integrated evidence, and undertook and used novel methodological epidemiological work to develop the first evidence-based and costed commissioning exemplar. …”
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“…Endemic countries are increasingly adopting molecular tools for efficient typing, identification and surveillance against malaria parasites and vector mosquitoes, as an integral part of their control programs(1,2,3,4,5). …”
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“…To support the CHA, Connect developed supervisory systems, launched information and monitoring operations, and implemented logistics support for integration with existing district and village operations. …”
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“…Automated and semi-automated queriable reports have been developed and are integral to demonstrating specific use-case scenarios in which the BRD would be beneficial for end-users. …”
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“…Distribute was a national emergency department syndromic surveillance project developed by the International Society for Disease Surveillance for influenza-like-illness (ILI) that integrated data from existing state and local public health department surveillance systems, and operated from 2006 until mid 2012. …”
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“…RESULTS: Tests were conducted on one of the proposed methods with an epidemiological dataset from the Integrated Health Interview Series (IHIS) producing verifiably unbiased results despite high missingness rates. …”
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“…Complex interactions between communicable diseases and NCDs demand an integrated approach to management, which must include the empowerment of affected populations to promote behavioural change.…”
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“…The aim of the surgical treatment is the increase of the quality of life of these children and adolescents and of their social integration. Methods and results. In the above-mentioned period, from the OI patients who are in the evidence of our clinic, 32 were operated on, totaling 81 surgeries. …”
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“…For added security, as well as for trustworthiness, a method of verifying authenticity, integrity and authorship is required, which can be provided using a public key infrastructure (PKI) for cryptography (2). …”
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“…While declarations of conflicts of interest (COI) have become an integral part of medical articles, COIs are often not declared completely and accurately. …”
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“…Serum antibodies were harvested and effects on P. falciparum sporozoites mobility and integrity were examined using phase contrast microscopy. …”
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“…In summary, the current report indicates a substantial improvement in in-hospital acute stroke care, but also emphasizes the need for enhancing public awareness and integrating the prehospital EMS system into acute stroke management. …”
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“…CONCLUSIONS: Despite the availability of methodological guidelines that can be utilized to guide the proper conduct of systematic reviews and meta-analyses and eliminate potential risks of bias, this knowledge has not yet been fully integrated in the area of home telemonitoring. Further efforts should be made to improve the design, conduct, reporting, and publication of systematic reviews and meta-analyses in this area.…”
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“…These findings highlight the public health importance of integrated genus-wide malaria control strategies in areas of Plasmodium co-endemicity. …”
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“…The quantification of RNA samples was carried out using an Agilent 2100 Bioanalyser to determine the RNA integrity number (RIN). The Agilent Low Input Quick Amplification Labelling kit was used to generate cRNA in two-color microarray analysis. …”
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