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329641por Aojula, Anuriti, Botfield, Hannah, McAllister, James Patterson, Gonzalez, Ana Maria, Abdullah, Osama, Logan, Ann, Sinclair, Alexandra“…At 14-days post-kaolin, just prior to sacrifice, routine magnetic resonance imaging and magnetic resonance diffusion tensor imaging was conducted and the mean diffusivity, fractional anisotropy, radial and axial diffusivity of seven cerebral regions were assessed by voxel-based analysis in the corpus callosum, periventricular white matter, caudal internal capsule, CA1 hippocampus, and outer and inner parietal cortex. Myelin integrity, gliosis and aquaporin-4 levels were evaluated by post-mortem immunohistochemistry in the CA3 hippocampus and in the caudal brain of the same cerebral structures analysed by diffusion tensor imaging. …”
Publicado 2016
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329642por O'Donoghue, Michelle L., Morrow, David A., Cannon, Christopher P., Jarolim, Petr, Desai, Nihar R., Sherwood, Matthew W., Murphy, Sabina A., Gerszten, Robert E., Sabatine, Marc S.“…When added to the TIMI STEMI Risk Score alone, the multimarker risk score significantly improved the C‐statistic (area under the curve, 0.75 [95% CI, 0.69–0.81] to 0.82 [0.78–0.87]; P=0.001), net reclassification index (0.93; P<0.001), and integrated discrimination index (0.09; P<0.001). CONCLUSIONS: In patients with STEMI, a multimarker strategy that combines biomarkers across pathobiological axes of myocardial stress, myocyte necrosis, and inflammation provides incremental prognostic information for prediction of cardiovascular death or HF.…”
Publicado 2016
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329643por Shah, Sachita P., Shah, Sachin P., Fils-Aime, Reginald, Desir, Walkens, Joasil, Joanel, Venesy, David M., Muruganandan, Krithika Meera“…Clinicians were able to integrate CPUS into their clinical impressions and management plans and reported a high level of confidence in their ultrasound findings.…”
Publicado 2016
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329644“…METHODS: Data are drawn from the cross-sectional Integrated Behavioural and Biological Assessment (2009) of 1650 male IDUs from two districts each of Manipur and Nagaland. …”
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329645por Eivazzadeh, Shahryar, Anderberg, Peter, Larsson, Tobias C, Fricker, Samuel A, Berglund, Johan“…The method was extended to integrate its generated ontology with the evaluation aspects suggested by model-based evaluation frameworks. …”
Publicado 2016
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329646por Chiu, Hui-Fang, Wu, Ying-Hua, Shen, You-Cheng, Wang, Shing-Jung, Venkatakrishnan, Kamesh, Wang, Chin-Kun“…CONCLUSIONS: Oral administration of SWT for 6 months improved the antioxidant level and positively regulated the lipid profile, liver function, and skin integrity and texture. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13020-016-0102-0) contains supplementary material, which is available to authorized users.…”
Publicado 2016
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329647“…These findings call for the need of integrated interventional management on diabetic knowledge, self-care behaviours and adherence to medications. …”
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329648por Scarpa, Joseph R., Jiang, Peng, Losic, Bojan, Readhead, Ben, Gao, Vance D., Dudley, Joel T., Vitaterna, Martha H., Turek, Fred W., Kasarskis, Andrew“…Furthermore, we present a unified systems-based framework for identifying gene networks that are associated with complex non-motor traits that manifest in the earliest phases of HD. By analyzing and integrating multiple independent datasets, we identify a point of molecular convergence between sleep, stress, and HD that reflects their phenotypic comorbidity and reveals a molecular pathway involved in HD progression.…”
Publicado 2016
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329649por Zhu, Honglin, Mi, Wentao, Luo, Hui, Chen, Tao, Liu, Shengxi, Raman, Indu, Zuo, Xiaoxia, Li, Quan-Zhen“…RESULTS: We identified 552 upregulated genes and 550 downregulated genes in PBMC of SLE. Integration of DNA methylation and gene expression profiling showed that 334 upregulated genes were hypomethylated, and 479 downregulated genes were hypermethylated. …”
Publicado 2016
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329650por Sheth, Ujash, Wasserstein, David, Moineddin, Rahim, Jenkinson, Richard, Kreder, Hans, Jaglal, Susan“…A time series analysis using an interventional autoregressive integrated moving average (ARIMA) model was used to determine whether changes in the proportion of surgically repaired ruptures were chronologically related to the dissemination of results from a landmark trial by Willits et al. …”
Publicado 2016
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329651“…CONCLUSIONS: We found a substantial burden of comorbid non-communicable diseases among HIV infected patients in a high HIV and low-income setting. Integrating non-communicable diseases care, including active screening, with HIV care is recommended.…”
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329652por Gillis, William Q., Kirmizitas, Arif, Iwasaki, Yasuno, Ki, Dong-Hyuk, Wyrick, Jonathan M., Thomsen, Gerald H.“…Dysregulated Wnt/β-catenin signaling causes diseases and birth defects, and a variety of regulatory processes control this pathway to ensure its proper function and integration with other signaling systems. We previously identified GTP-binding protein 2 (Gtpbp2) as a novel regulator of BMP signaling, however further exploration revealed that Gtpbp2 can also affect Wnt signaling, which is a novel finding reported here. …”
Publicado 2016
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329653por Liang, Guanxiang, Malmuthuge, Nilusha, Bao, Hua, Stothard, Paul, Griebel, Philip J., Guan, Le Luo“…Moreover, the expression of mucosal immune-related genes were either positively or negatively correlated with total bacterial population depending on both intestinal region and age. The integrated analysis of miRNAs and mRNAs supported the conclusion that miRNAs may regulate temporal changes in the expression of genes encoding tight junction proteins (miR-335), cytokines (miR-335) and bacterial recognition (miR-100) during the first week of small intestine development. …”
Publicado 2016
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329654por Tomori, Cecilia, McFall, Allison M., Srikrishnan, Aylur K., Mehta, Shruti H., Nimmagadda, Nymisha, Anand, Santhanam, Vasudevan, Canjeevaram K., Solomon, Suniti, Solomon, Sunil S., Celentano, David D.“…Our results suggest an acute need for the development of CSA prevention interventions and the integration of mental health services for MSM with histories of CSA as part of HIV-prevention efforts. …”
Publicado 2016
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329655“…All nine of these apps were also capable of collecting physical activity (PA) information using self-report, the global positioning system (GPS), or wearable integrations. Their outputs focused predominantly on energy balance between dietary intake and PA. …”
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329656“…The housing systems studied include a conventional cage house (200,000 hen capacity), an aviary house (50,000 hen capacity), and an enriched colony house (50,000 hen capacity). As an integral part of the CSES project, continual environmental monitoring over a 27-month period described in this paper quantifies indoor gaseous and particulate matter concentrations, thermal environment, and building ventilation rate of each house. …”
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329657“…RESULTS: In keloid and normal keratinocytes, TGF-β1 regulated expression of EMT-related genes, including hyaluronan synthase 2, vimentin, cadherin-11, wingless-type MMTV integration site family, member 5A, frizzled 7, ADAM metallopeptidase domain 19, and interleukin-6. …”
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329658por Jiang, Guanglong, Zhang, Shijun, Yazdanparast, Aida, Li, Meng, Pawar, Aniruddha Vikram, Liu, Yunlong, Inavolu, Sai Mounika, Cheng, Lijun“…A total score developed from the four correlations among four molecular profiles suggests that cell lines, BT483, T47D and MDAMB453 have the highest similarity with tumors. CONCLUSIONS: The integrated data from across these multiple platforms demonstrates the existence of the similarity and dissimilarity of molecular features between breast cancer tumors and cell lines. …”
Publicado 2016
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329659“…Routine screening services for T. gondii infection should be integrated with other ANC services to identify potential infections of the parasite.…”
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329660por de Seny, Dominique, Cobraiville, Gaël, Leprince, Pierre, Fillet, Marianne, Collin, Charlotte, Mathieu, Myrielle, Hauzeur, Jean-Philippe, Gangji, Valérie, Malaise, Michel G.“…RESULTS: From the 35 HV and 33 NU crude serum samples and Proteominer® eluates, 136 spectra were collected by SELDI-TOF–MS using CM10 and IMAC-Cu(2+) ProteinChip arrays, and 665 peaks were integrated for extra-trees multivariate analysis. Accordingly, seven biomarkers and several variants were identified as potential NU biomarkers. …”
Publicado 2016
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