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  1. 329941
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    Our evolved unique pleasure circuit makes humans different from apes: Reconsideration of data derived from animal studies
  2. 329942
    “…Nowadays dental implants became the most popular line of treatment to replace missing teeth; offering a comfortable long lasting prosthesis. Osseo-integration reflects the long term success of a dental implant. …”
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    Evaluation of The Bio-Stimulatory Effect of Platelet Rich Fibrin Augmented by Diode LASER Compared to Platelet Rich Fibrin Alone on Dental Implant Replacing Posterior Mandibular Teeth. Randomised Clinical Trial: Split Mouth Study
  3. 329943
    “…During four separate in-hospital visits, the participants performed two unannounced exercise protocols: moderate intensity (55% of [Formula: see text] ) and moderate intensity with integrated high-intensity sprints (55/80% of [Formula: see text] ), using the same study device either for closed-loop or open-loop insulin delivery. …”
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    Closed-loop glucose control in young people with type 1 diabetes during and after unannounced physical activity: a randomised controlled crossover trial
  4. 329944
    “…Functional enrichment analysis was performed and revealed that high or moderate impact variants in wingless-related integration site (Wnt) and vascular smooth muscle contraction (VSMC) signaling pathways were significantly over-represented in tropically adapted heat tolerant Pakistani-indicine breeds. …”
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    Genomic variants identified from whole-genome resequencing of indicine cattle breeds from Pakistan
  5. 329945
    “…Access to OST and needle and syringe services needs to be increased and integrated with HCV services. Social and structural factors affecting PWID who live on the street need to be addressed.…”
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    Understanding hepatitis B, hepatitis C and HIV among people who inject drugs in South Africa: findings from a three-city cross-sectional survey
  6. 329946
    “…Rapid and cost-effective estimation of plant height from airborne devices using a digital surface model can be integrated with academic research and practical wheat breeding programs. …”
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    Accuracy assessment of plant height using an unmanned aerial vehicle for quantitative genomic analysis in bread wheat
  7. 329947
    “…The tumor microenvironment (TME) plays key roles in promoting disease progression in the aggressive triple-negative subtype of breast cancer (TNBC; Basal/Basal-like). Here, we took an integrative approach and determined the impact of tumor-stroma-inflammation networks on pro-metastatic phenotypes in TNBC. …”
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    Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer
  8. 329948
    por Chang, Wai Hoong, Lai, Alvina G.
    Publicado 2019
    “…Yet, detailed pan-cancer evidence supporting this notion has been limited. METHODS: In an integrated approach uniting genomic, transcriptomic and clinical data of 21 cancer types (n = 18,484), we interrogated copy number and transcript profiles of 32 circadian clock genes to identify putative loss-of-function (Clock(Loss)) and gain-of-function (Clock(Gain)) players. …”
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    Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies
  9. 329949
    “…The most common cause of death and re‐hospitalization after hospital discharge was HF, but non‐cardiac causes also contributed to their prognosis. Integrated management approaches will be required for HF patients.…”
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    Clinical characteristics of hospitalized heart failure patients with preserved, mid‐range, and reduced ejection fractions in Japan
  10. 329950
    “…With BP data transfer from an automatic BP monitor via Bluetooth to software, for example, a smartphone app, home measurement could effectively be integrated into regular care. OBJECTIVE: The aim of this study was to validate two commercially available automatic BP monitors with the ability to transfer BP data via Bluetooth (Beurer BM 85 and Andersson Lifesense BDR 2.0), against manual BP monitoring in patients with type 2 diabetes. …”
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    Validation of Two Automatic Blood Pressure Monitors With the Ability to Transfer Data via Bluetooth
  11. 329951
    “…This study, as the first estimation of potential soil erosion at Prosecco DOCG scale, suggests that an integrated and public soil erosion monitoring system is strongly needed in viticultural area, by implementing direct/indirect field measures with spatial analyses at agricultural landscape scale.…”
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    Estimation of potential soil erosion in the Prosecco DOCG area (NE Italy), toward a soil footprint of bottled sparkling wine production in different land-management scenarios
  12. 329952
    “…ChIP-seq experiments revealed H3K4me3 and H3K9me3 had only minor changes in response to light in WT, but there were notable alterations in H3K4me3 in Δkmt1/Δdim-5 and H3K9me3 in Δkmt2/Δset-1 indicating crosstalk and redistribution between the modifications. Integrated analysis of the RNA-seq and ChIP-seq highlighted context-dependent roles for KMT2/SET1 and KMT1/DIM-5 as either co-activators or co-repressors with some overlap as co-regulators. …”
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    Histone H3 lysine 4 methyltransferase is required for facultative heterochromatin at specific loci
  13. 329953
    “…METHODS: The seasonal auto-regressive integrated moving average method (SARIMA) was employed to predict RTI time series. …”
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    Time trends in gender-specific incidence rates of road traffic injuries in Iran
  14. 329954
    “…BACKGROUND: In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued development. …”
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    Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide (47)Sc
  15. 329955
    “…Muscle strength and activation (peak force [PF]; peak amplitude [Peak Amp.] and root mean square of integrated electromyography [RMS iEMG]), muscular size (including rectus femoris muscle cross-sectional area [CSA(RF)]), and knee ROM were assessed on three separate occasions (pre-surgery [0 weeks]; 8 weeks post-surgery; 14 weeks post-surgery). …”
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    Early initiation of home-based sensori-motor training improves muscle strength, activation and size in patients after knee replacement: a secondary analysis of a controlled clinical trial
  16. 329956
    “…The support tool was integrated into the electronic health record system used by the study clinics and modified to offer videos to all adolescents regardless of their tobacco use or susceptibility. …”
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    Considerations of Privacy and Confidentiality in Developing a Clinical Support Tool for Adolescent Tobacco Prevention: Qualitative Study
  17. 329957
    “…Our results underline that the signaling adaptor CRKL might integrate the external and intrinsic cellular signals and coordinate the dynamic activation of cellular signaling pathways including alternative splicing regulation. …”
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    CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell
  18. 329958
    “…However, when introducing new technology to patients, their subjective experiences are crucial in identifying risks, further development, and potential integration into clinical care. OBJECTIVE: The objective was to explore the feasibility and acceptability of a newly developed mobile phone app in adolescents with EOP by examining compliance with the app and user experiences. …”
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    Feasibility and Acceptability of Using a Mobile Phone App for Characterizing Auditory Verbal Hallucinations in Adolescents With Early-Onset Psychosis: Exploratory Study
  19. 329959
    “…Based on this finding, it could possibly integrate into A08 of B. napus using marker assisted selection with SNP markers tightly linked to Rcr6 developed in this study. …”
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    Clubroot resistance gene Rcr6 in Brassica nigra resides in a genomic region homologous to chromosome A08 in B. rapa
  20. 329960
    “…Collectively, our findings indicate that neurons of MS patients acquire sustained hypo-5mC and hyper-5hmC, which may impair CREB-mediated neuro-axonal integrity, in turn relating to clinical symptoms. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13148-019-0678-1) contains supplementary material, which is available to authorized users.…”
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    Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis
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