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333741“…OBJECTIVE: Pembrolizumab has become an integral first line therapeutic agent for non-small cell lung cancer (NSCLC), but its potential predictive role in clinical and molecular characteristics remains to be clarified. …”
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333742por Chen, Feng, Lin, Weijun, Li, Wei, Hu, Jinhe, Li, Zhi, Shi, Lingling, Zhang, Zhixiang, Xiu, Yu, Lin, Shanzhi“…FA biosynthesis and oil accumulation of oil plants are known to be highly controlled by the transcription factors. An integrated analysis of our recent transcriptome data, qRT-PCR detection and functional identification was performed as an attempt to highlight LEC1/WRI1-mediated transcription regulatory mechanism for high-quality oil accumulation in P. chinensis seeds. …”
Publicado 2023
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333743por Deckert, Andreas, Anders, Simon, Morales, Ivonne, De Allegri, Manuela, Nguyen, Hoa Thi, Souares, Aurélia, McMahon, Shannon, Meurer, Matthias, Burk, Robin, Lou, Dan, Brugnara, Lucia, Sand, Matthias, Koeppel, Lisa, Maier-Hein, Lena, Ross, Tobias, Adler, Tim J, Brenner, Stephan, Dyer, Christopher, Herbst, Konrad, Ovchinnikova, Svetlana, Marx, Michael, Schnitzler, Paul, Knop, Michael, Bärnighausen, Till, Denkinger, Claudia M“…Efforts to improve participation rates and integration into the public health system may increase the potential to monitor the course of the pandemic. …”
Publicado 2023
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333744“…Multiple DNA double-strand breaks (DSBs) were detected in SK-BR-3 cells exposed to [(225)Ac]Ac-DOTA-trastuzumab by γ-H2AX immunofluorescence microscopy. The time-integrated activity of [(111)In]In-DOTA-trastuzumab in SK-BR-3 cells was measured and used to estimate the absorbed doses from [(225)Ac]Ac-DOTA-trastuzumab by Monte Carlo N-Particle simulation for correlation with the SF. …”
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333745“…Studies have shown an integral role of S100 calcium-binding proteins in the diagnosis, treatment, and prognosis of certain diseases (Cancers 12:2037, 2020). …”
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333746por Craddock, R. Cameron, Bellec, Pierre, Margules, Daniel S., Nichols, B. Nolan, Pfannmöller, Jörg P., Badhwar, AmanPreet, Kennedy, David, Poline, Jean-Baptiste, Toro, Roberto, Cipollini, Ben, Rokem, Ariel, Clark, Daniel, Gorgolewski, Krzysztof J., Craddock, R. Cameron, Craddock, R. Cameron, Clark, Daniel J., Das, Samir, Madjar, Cécile, Sengupta, Ayan, Mohades, Zia, Dery, Sebastien, Deng, Weiran, Earl, Eric, Demeter, Damion V., Mills, Kate, Mihai, Glad, Ruzic, Luka, Ketz, Nick, Reineberg, Andrew, Reddan, Marianne C., Goddings, Anne-Lise, Gonzalez-Castillo, Javier, Gorgolewski, Krzysztof J., Froehlich, Caroline, Dekel, Gil, Margulies, Daniel S., Craddock, R. Cameron, Fulcher, Ben D., Glatard, Tristan, Das, Samir, Adalat, Reza, Beck, Natacha, Bernard, Rémi, Khalili-Mahani, Najmeh, Rioux, Pierre, Rousseau, Marc-Étienne, Evans, Alan C., Halchenko, Yaroslav O., Castello, Matteo Visconti di Oleggio, Hernández-Pérez, Raúl, Morales, Edgar A., Cuaya, Laura V., Ito, Kaori L., Liew, Sook-Lei, Johnson, Hans J., Kan, Erik, Anglin, Julia, Borich, Michael, Jahanshad, Neda, Thompson, Paul, Liew, Sook-Lei, Margulies, Daniel S., Falkiewicz, Marcel, Huntenburg, Julia M., O’Connor, David, Clark, Daniel J., Milham, Michael P., Craddock, R. Cameron, Pereira, Ramon Fraga, Heinsfeld, Anibal Sólon, Franco, Alexandre Rosa, Buchweitz, Augusto, Meneguzzi, Felipe, Pfannmöller, Jörg P., Mesquita, Rickson, Herrera, Luis C. T., Dentico, Daniela, Sochat, Vanessa, Nichols, B. Nolan, Heinsfeld, Anibal Sólon, Franco, Alexandre Rosa, Buchweitz, Augusto, Meneguzzi, Felipe, Villalon-Reina, Julio E., Garyfallidis, Eleftherios“…Pfannmöller A1 Distributed collaboration: the case for the enhancement of Brainspell’s interface AmanPreet Badhwar, David Kennedy, Jean-Baptiste Poline, Roberto Toro A2 Advancing open science through NiData Ben Cipollini, Ariel Rokem A3 Integrating the Brain Imaging Data Structure (BIDS) standard into C-PAC Daniel Clark, Krzysztof J. …”
Publicado 2016
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333747por Saslow, Laura R, Mason, Ashley E, Kim, Sarah, Goldman, Veronica, Ploutz-Snyder, Robert, Bayandorian, Hovig, Daubenmier, Jennifer, Hecht, Frederick M, Moskowitz, Judith T“…BACKGROUND: Type 2 diabetes is a prevalent, chronic disease for which diet is an integral aspect of treatment. In our previous trial, we found that recommendations to follow a very low-carbohydrate ketogenic diet and to change lifestyle factors (physical activity, sleep, positive affect, mindfulness) helped overweight people with type 2 diabetes or prediabetes improve glycemic control and lose weight. …”
Publicado 2017
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333748por Böhmer, Merle M, Buchholz, Udo, Corman, Victor M, Hoch, Martin, Katz, Katharina, Marosevic, Durdica V, Böhm, Stefanie, Woudenberg, Tom, Ackermann, Nikolaus, Konrad, Regina, Eberle, Ute, Treis, Bianca, Dangel, Alexandra, Bengs, Katja, Fingerle, Volker, Berger, Anja, Hörmansdorfer, Stefan, Ippisch, Siegfried, Wicklein, Bernd, Grahl, Andreas, Pörtner, Kirsten, Muller, Nadine, Zeitlmann, Nadine, Boender, T Sonia, Cai, Wei, Reich, Andreas, an der Heiden, Maria, Rexroth, Ute, Hamouda, Osamah, Schneider, Julia, Veith, Talitha, Mühlemann, Barbara, Wölfel, Roman, Antwerpen, Markus, Walter, Mathias, Protzer, Ulrike, Liebl, Bernhard, Haas, Walter, Sing, Andreas, Drosten, Christian, Zapf, Andreas“…Whole genome sequencing was used to confirm epidemiological links and clarify transmission events where contact histories were ambiguous; integration with epidemiological data enabled precise reconstruction of exposure events and incubation periods. …”
Publicado 2020
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333749por Price, Gareth W., Chadjichristos, Christos E., Kavvadas, Panagiotis, Tang, Sydney C. W., Yiu, Wai Han, Green, Colin R., Potter, Joe A., Siamantouras, Eleftherios, Squires, Paul E., Hills, Claire E.“…GRAPHICAL ABSTRACT: In proximal tubular epithelial cells (PTECs), tight junction proteins, including zona occuludens-1 (ZO-1), contribute to epithelial integrity, whilst the adherens junction protein epithelial (E)-cadherin (ECAD) maintains cell-cell coupling, facilitating connexin 43 (Cx43) gap junction-mediated intercellular communication (GJIC) and the direct transfer of small molecules and ions between cells. …”
Publicado 2020
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333750“…We next evaluated the impact of repeated VHP treatment on physical features, permeability, and fabric integrity of coveralls and N-95 masks. Next, we performed Scanning Electron Microscopy (SEM) to evaluate microscopic changes in fiber thickness of N-95 masks, melt blown layer or coverall body suits. …”
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333751por Buis, Lorraine R, Roberson, Dana N, Kadri, Reema, Rockey, Nicole G, Plegue, Melissa A, Danak, Shivang U, Guetterman, Timothy C, Johnson, Melanie G, Choe, Hae Mi, Richardson, Caroline R“…Furthermore, stakeholders require integration into the electronic health record and a modified clinical workflow for BPTrack to be truly useful; however, both patients and stakeholders perceived benefits of BPTrack when used within the context of a clinical relationship. …”
Publicado 2020
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333752por Alvarez-Jimenez, Mario, Rice, Simon, D'Alfonso, Simon, Leicester, Steven, Bendall, Sarah, Pryor, Ingrid, Russon, Penni, McEnery, Carla, Santesteban-Echarri, Olga, Da Costa, Gustavo, Gilbertson, Tamsyn, Valentine, Lee, Solves, Laia, Ratheesh, Aswin, McGorry, Patrick D, Gleeson, John“…All participants had access to interactive online therapy and integrated web chat counseling. Additional access to peer-to-peer social networking was granted to 73 participants (46.5%) for whom it was deemed safe. …”
Publicado 2020
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333753por Roehrig, Stefan, Ait Hssain, Ali, Shallik, Nabil Al Hamid, Elsaid, Ingi Mohamed A., Mustafa, Salma Faisal, Smain, Osama A. M., Molokhia, Ashraf Abdulla, Lance, Marcus D.“…OBJECTIVES: This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19.We define ARDS according to the “Berlin” definition integrating the oxygenation index (P/F ratio), the level of Positive End Expiratory Pressure (PEEP), radiological and clinical findings. …”
Publicado 2020
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333754por Mrklas, Kelly, Shalaby, Reham, Hrabok, Marianne, Gusnowski, April, Vuong, Wesley, Surood, Shireen, Urichuk, Liana, Li, Daniel, Li, Xin-Min, Greenshaw, Andrew James, Agyapong, Vincent Israel Opoku“…Our findings underscore the importance of anticipating and mitigating the mental health effects of pandemics using integrated implementation strategies. Finally, we demonstrate the ease of safely and rapidly assessing mental health needs using an SMS text messaging platform during a pandemic. …”
Publicado 2020
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333755por Wang, Hao, Zhou, Yongkang, Gan, Wutian, Chen, Hua, Huang, Ying, Duan, Yanhua, Feng, Aihui, Shao, Yan, Gu, Hengle, Kong, Qing, Xu, Zhiyong“…METHODS: Two kinds of hybrid plans named conventional fraction radiotherapy & stereotactic body radiotherapy (C&S) and conventional fraction radiotherapy & simultaneous integrated boost (C&SIB) were retrospectively made for 20 patients with stage III NSCLC. …”
Publicado 2021
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333756por Feldman, David, Kruger, Paola, Delbecque, Laure, Duenas, Ashley, Bernard-Poenaru, Oana, Wollenschneider, Séverine, Hicks, Nick, Reed, Janine Ann, Sargeant, Ify, Pakarinen, Chi, Hamoir, Anne-Marie“…CONCLUSIONS: The how-to guides form a comprehensive series of actionable and stepwise resources that build from and integrate the PE quality criteria across the medicines continuum. …”
Publicado 2021
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333757por Chen, Xing-Yong, Wan, Shao-Fen, Yao, Nan-Nan, Lin, Ze-Jing, Mao, Yan-Guang, Yu, Xiao-Hua, Wang, Yin-Zhou“…Analysis of the quantity of extravasated Evans blue (EB) and cerebral fluorescent angiography were performed to evaluate the integrity of the BBB. Immunofluorescence and Western blotting were employed to detect the expression of target proteins. …”
Publicado 2021
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333758“…These changes likely impact the integrity of the epithelial barriers, leading to loss of tolerance in the mast cell compartment. …”
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333759por Fumagalli, Francesca, Calbi, Valeria, Natali Sora, Maria Grazia, Sessa, Maria, Baldoli, Cristina, Rancoita, Paola Maria V, Ciotti, Francesca, Sarzana, Marina, Fraschini, Maddalena, Zambon, Alberto Andrea, Acquati, Serena, Redaelli, Daniela, Attanasio, Vanessa, Miglietta, Simona, De Mattia, Fabiola, Barzaghi, Federica, Ferrua, Francesca, Migliavacca, Maddalena, Tucci, Francesca, Gallo, Vera, Del Carro, Ubaldo, Canale, Sabrina, Spiga, Ivana, Lorioli, Laura, Recupero, Salvatore, Fratini, Elena Sophia, Morena, Francesco, Silvani, Paolo, Calvi, Maria Rosa, Facchini, Marcella, Locatelli, Sara, Corti, Ambra, Zancan, Stefano, Antonioli, Gigliola, Farinelli, Giada, Gabaldo, Michela, Garcia-Segovia, Jesus, Schwab, Laetitia C, Downey, Gerald F, Filippi, Massimo, Cicalese, Maria Pia, Martino, Sabata, Di Serio, Clelia, Ciceri, Fabio, Bernardo, Maria Ester, Naldini, Luigi, Biffi, Alessandra, Aiuti, Alessandro“…METHODS: This study is an integrated analysis of results from a prospective, non-randomised, phase 1/2 clinical study and expanded-access frameworks. 29 paediatric patients with pre-symptomatic or early-symptomatic early-onset MLD with biochemical and molecular confirmation of diagnosis were treated with arsa-cel, a gene therapy containing an autologous haematopoietic stem and progenitor cell (HSPC) population transduced ex vivo with a lentiviral vector encoding human arylsulfatase A (ARSA) cDNA, and compared with an untreated natural history (NHx) cohort of 31 patients with early-onset MLD, matched by age and disease subtype. …”
Publicado 2022
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333760por Bhattacharyya, Raja, Teves, Catarina Amelia Fidalgo, Long, Alexandra, Hofert, Madison, Tanzi, Rudolph E.“…Genome-wide association studies have identified BIN1 (Bridging integrator 1) and RIN3 (Ras and Rab interactor 3) as genetic risk factors for late-onset Alzheimer’s disease (LOAD). …”
Publicado 2022
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