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333821por Varma, Vijay R., Oommen, Anup M., Varma, Sudhir, Casanova, Ramon, An, Yang, Andrews, Ryan M., O’Brien, Richard, Pletnikova, Olga, Troncoso, Juan C., Toledo, Jon, Baillie, Rebecca, Arnold, Matthias, Kastenmueller, Gabi, Nho, Kwangsik, Doraiswamy, P. Murali, Saykin, Andrew J., Kaddurah-Daouk, Rima, Legido-Quigley, Cristina, Thambisetty, Madhav“…We then assayed these 26 metabolites in serum samples from two well-characterized longitudinal cohorts representing prodromal (Alzheimer’s Disease Neuroimaging Initiative [ADNI], N = 767, mean age = 75.19, % female = 42.63) and preclinical (BLSA) (N = 207, mean age = 78.68, % female = 42.63) AD, in which we tested their associations with magnetic resonance imaging (MRI) measures of AD-related brain atrophy, cerebrospinal fluid (CSF) biomarkers of AD pathology, risk of conversion to incident AD, and trajectories of cognitive performance. We developed an integrated blood and brain endophenotype score that summarized the relative importance of each metabolite to severity of AD pathology and disease progression (Endophenotype Association Score in Early Alzheimer’s Disease [EASE-AD]). …”
Publicado 2018
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333822por Martins da Silva, Sarah J., Brown, Sean G., Sutton, Keith, King, Louise V., Ruso, Halil, Gray, David W., Wyatt, Paul G., Kelly, Mark C., Barratt, Christopher L.R., Hope, Anthony G.“…Hit compounds identified following single point drug screen (10 μM) of an ion channel-focussed library assembled by the University of Dundee Drug Discovery Unit were rescreened to ensure potency using standard 10 point half-logarithm concentration curves, and tested for purity and integrity using liquid chromatography and mass spectrometry. …”
Publicado 2017
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333823por McGreevy, Paul, Berger, Jeannine, de Brauwere, Nic, Doherty, Orla, Harrison, Anna, Fiedler, Julie, Jones, Claudia, McDonnell, Sue, McLean, Andrew, Nakonechny, Lindsay, Nicol, Christine, Preshaw, Liane, Thomson, Peter, Tzioumis, Vicky, Webster, John, Wolfensohn, Sarah, Yeates, James, Jones, Bidda“…Scores for Domain 5 (the integrated mental impact) gathered after extensive discussion during a four-day workshop aligned well with overall impact scores assigned by the same panellists individually before the workshop, although some rankings changed after workshop participation. …”
Publicado 2018
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333824por Mullany, Luke C., van Boetzelaer, Elburg W., Gutman, Julie R., Steinhardt, Laura C., Ngoy, Pascal, Barbera Lainez, Yolanda, Wittcoff, Alison, Harvey, Steven A., Ho, Lara S.“…BACKGROUND: The World Health Organization’s integrated community case management (iCCM) guidelines recommend that all children presenting with uncomplicated fever and no danger signs return for follow-up on day 3 following the initial consultation on day 1. …”
Publicado 2018
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333825por Sarrazin, Christoph, Tran, Tram, Dylla, Douglas, Feld, Jordan J, Arora, Sanjeev, Victor, David, Hu, Yiran B, Wang, Stanley, Mensa, Federico, Wyles, David L“…BACKGROUND: The pangenotypic direct-acting antivirals (DAAs) glecaprevir (developed by AbbVie and Enanta) coformulated with pibrentasvir (G/P) are approved as an 8-week regimen to treat chronic HCV infection for all six major genotypes (GT). An integrated analysis of patients treated with G/P for 8 weeks was performed to investigate factors impacting time to viral suppression, and whether lack of viral suppression by treatment week 4 was predictive of relapse. …”
Publicado 2018
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333826por Riper, Heleen, Hoogendoorn, Adriaan, Cuijpers, Pim, Karyotaki, Eirini, Boumparis, Nikolaos, Mira, Adriana, Andersson, Gerhard, Berman, Anne H., Bertholet, Nicolas, Bischof, Gallus, Blankers, Matthijs, Boon, Brigitte, Boß, Leif, Brendryen, Håvar, Cunningham, John, Ebert, David, Hansen, Anders, Hester, Reid, Khadjesari, Zarnie, Kramer, Jeannet, Murray, Elizabeth, Postel, Marloes, Schulz, Daniela, Sinadinovic, Kristina, Suffoletto, Brian, Sundström, Christopher, de Vries, Hein, Wallace, Paul, Wiers, Reinout W., Smit, Johannes H.“…Participants treated in iAIs based on personalised normative feedback (PNF) alone were significantly less likely to sustain low-risk drinking at follow-up than those in iAIs based on integrated therapeutic principles (OR = 0.52, 95% CI 0.29–0.93, p = 0.029). …”
Publicado 2018
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333827por D’Almeida, Olga, Mothar, Omar, Bondzie, Esther Apraku, Lieumo, Yolande, Tagne, Laure, Gupta, Sumeet, Volkert, Thomas, Levine, Stuart, Tagne, Jean-Bosco“…RESULTS: Due to their effectiveness as intracellular vesicles transporting miR-200c into, out, and between parts of the cells, miR-200c is encapsulated with cholesterol, an integral part of the biological membranes with very important physical properties of the vehicle. …”
Publicado 2019
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333828por Costello, M F, Misso, M L, Balen, A, Boyle, J, Devoto, L, Garad, R M, Hart, R, Johnson, L, Jordan, C, Legro, R S, Norman, R J, Mocanu, E, Qiao, J, Rodgers, R J, Rombauts, L, Tassone, E C, Thangaratinam, S, Vanky, E, Teede, H J“…Research recommendations have been generated and a comprehensive multifaceted dissemination and translation program supports the guideline with an integrated evaluation program. STUDY FUNDING/COMPETING INTEREST(S): The guideline was primarily funded by the Australian National Health and Medical Research Council of Australia (NHMRC) supported by a partnership with ESHRE and the American Society for Reproductive Medicine (ASRM). …”
Publicado 2019
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333829por Duhig, Kate E, Myers, Jenny, Seed, Paul T, Sparkes, Jenie, Lowe, Jessica, Hunter, Rachael M, Shennan, Andrew H, Chappell, Lucy C“…We therefore aimed to determine whether knowledge of the circulating concentration of placental growth factor (PlGF), an angiogenic factor, integrated with a clinical management algorithm, decreased the time for clinicians to make a diagnosis in women with suspected pre-eclampsia, and whether this approach reduced subsequent maternal or perinatal adverse outcomes. …”
Publicado 2019
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333830Publicado 2019“…HIV incidence was high in this population of women seeking pregnancy prevention, emphasising the need for integration of HIV prevention within contraceptive services for African women. …”
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333831por Goga, Ameena E., Dinh, Thu-Ha, Essajee, Shaffiq, Chirinda, Witness, Larsen, Anna, Mogashoa, Mary, Jackson, Debra, Cheyip, Mireille, Ngandu, Nobubelo, Modi, Surbhi, Bhardwaj, Sanjana, Chirwa, Esnat, Pillay, Yogan, Mahy, Mary“…Although by 2016 EMTCT-validated countries and Global Plan priority countries had adopted a public health approach to HIV prevention, recommending lifelong antiretroviral therapy (ART) for all HIV-positive pregnant and lactating women, EMCT-validated countries had also included contact tracing such as assisted partner notification, and had integrated maternal and child health (MCH) and sexual and reproductive health (SRH) services, with services for HIV infection, sexually transmitted infections, and viral hepatitis. …”
Publicado 2019
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333832por Wasko, Molly, Morrato, Elaine, Kenyon, Nicholas, Rajguru, Suhrud, Conway, Bruce, Love, Sara, Hafer, Nate, Bhatti, Pamela, Fay, Jonathan, Zonies, Seth“…We believe that an I-Corps@NCATS program will enhance the process of scientific translation by taking best practices from NSF I-Corps and adapting the program to meet the needs of biomedical scientists in academic medical centers. By integrating I-Corps@NCATS training, we hypothesize that the clinical and translational investigator base will be better prepared to identify new innovations and to accelerate translation through commercialization. …”
Publicado 2018
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333833“…Specifically, extant literature has shown that quantifiable indices of cognitive deficits may represent a vulnerability to psychosis in high-risk populations, and can be measured using event-related potentials (ERPs). This study integrates a psychophysiological approach by mapping neural deficits from schizophrenia onto a high-risk sample. …”
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333834por Cho, Soo Young, Park, Jun Won, Liu, Yang, Park, Young Soo, Kim, Ju Hee, Yang, Hanna, Um, Hyejin, Ko, Woo Ri, Lee, Byung Il, Kwon, Sun Young, Ryu, Seung Wan, Kwon, Chae Hwa, Park, Do Youn, Lee, Jae-Hyuk, Lee, Sang Il, Song, Kyu Sang, Hur, Hoon, Han, Sang-Uk, Chang, Heekyung, Kim, Su-Jin, Kim, Byung-Sik, Yook, Jeong-Hwan, Yoo, Moon-Won, Kim, Beom-Su, Lee, In-Seob, Kook, Myeong-Cherl, Thiessen, Nina, He, An, Stewart, Chip, Dunford, Andrew, Kim, Jaegil, Shih, Juliann, Saksena, Gordon, Cherniack, Andrew D., Schumacher, Steven, Weiner, Amaro-Taylor, Rosenberg, Mara, Getz, Gad, Yang, Eun Gyeong, Ryu, Min-Hee, Bass, Adam J., Kim, Hark Kyun“…CONCLUSIONS: In an integrative genomic analysis, we found higher proportions of early-onset DGCs to contain somatic mutations in CDH1 or TGFBR1 compared with late-onset DGCs. …”
Publicado 2017
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333835por Teede, Helena J., Misso, Marie L., Costello, Michael F., Dokras, Anuja, Laven, Joop, Moran, Lisa, Piltonen, Terhi, Norman, Robert. J.“…Research recommendations have been generated and a comprehensive multifaceted dissemination and translation program supports the guideline with an integrated evaluation program. STUDY FUNDING/COMPETING INTEREST(S): The guideline was primarily funded by the Australian National Health and Medical Research Council of Australia (NHMRC) supported by a partnership with ESHRE and the American Society for Reproductive Medicine. …”
Publicado 2018
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333836“…The purpose of this article is to highlight the likely pathogens responsible for oral cavity infections, and to suggest ways to integrate the clinical and laboratory diagnosis to establish an accurate microbiologic diagnosis for these infectious diseases.…”
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333837por Schooler, Nina, Robinson, Delbert, Marcy, Patricia, Homan, Philipp, Achtyes, Eric, Kane, John M“…DISCUSSION: Recently hospitalized patients with schizophrenia who received an integrated technology informed relapse prevention program (HTP) experienced fewer days in the hospital compared to those who received usual care in the six months following their discharge. …”
Publicado 2020
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333838por Corsi-Zuelli, Fabiana, Marques, Leonardo, Leite da Roza, Daiane, Marcelino Loureiro, Camila, Shuhama, Rosana, Rossi Menezes, Paulo, Louzada-Junior, Paulo, Marta Del-Ben, Cristina“…METHODS: The Schizophrenia and Other Psychoses Translational Research: Environment and Molecular Biology (STREAM) is an epidemiological and case-sibling-control study, conducted in Ribeirão Preto catchment area (São Paulo, Brazil) between April 2012 and March 2015, which integrates the international multicentre consortium EU-GEI. …”
Publicado 2020
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333839por Quinn, Kieran L, Stukel, Therese, Stall, Nathan M, Huang, Anjie, Isenberg, Sarina, Tanuseputro, Peter, Goldman, Russell, Cram, Peter, Kavalieratos, Dio, Detsky, Allan S, Bell, Chaim M“…Linked health administrative data were used to directly match patients on cause of death, hospital frailty risk score, presence of metastatic cancer, residential location (according to 1 of 14 local health integration networks that organise all healthcare services in Ontario), and a propensity score to receive palliative care that was derived by using age and sex. …”
Publicado 2020
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333840por Peiffer-Smadja, N., Lucet, J.-C., Deconinck, L., Gérard, S., Giordano, L., Bendjelloul, G., Yazdanpanah, Y., Lescure, F.-X.“…Ont été soulignés par les participants l’importance de maintenir la cohésion des équipes entre personnels travaillant auprès de patients infectés par le SARS-CoV-2 et personnels non impliqués, d’intégrer de façon harmonieuse la recherche clinique dans la prise en charge médicale et de réaliser un travail de veille bibliographique en temps réel afin d’actualiser la prise en charge des cas possibles et confirmés. …”
Publicado 2020
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