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7401por Mosca, Ettore, Alfieri, Roberta, Merelli, Ivan, Viti, Federica, Calabria, Andrea, Milanesi, Luciano“…Due to the complexity of this disease, it is important to face its study with an integrated and multilevel approach, from genes, transcripts and proteins to molecular networks, cell populations and tissues. …”
Publicado 2010
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7402“…As sensory systems deteriorate in aging or disease, the brain must relearn the appropriate weights to assign each modality during multisensory integration. Using blood-oxygen level dependent functional magnetic resonance imaging of human subjects, we tested a model for the neural mechanisms of sensory weighting, termed “weighted connections.” …”
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7403“…RESULTS: Here we present rule-based mediation, a method of semantic data integration applied to systems biology model annotation. …”
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7404“…[Image: see text] We present an implicit solvent model based on the extended reference interaction site model (XRISM) integral equation theory, which is a molecular theory of solvation. …”
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7405“…CONCLUSIONS: Our Y chromosome analysis suggests that the same is protected from the effects of arsenic by some unknown mechanisms maintaining its structural and functional integrities. Thus, arsenic effects on the human body seem to be different compared to that on the cultured cells.…”
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7406
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7407por Radrich, Karin, Tsuruoka, Yoshimasa, Dobson, Paul, Gevorgyan, Albert, Swainston, Neil, Baart, Gino, Schwartz, Jean-Marc“…RESULTS: In this article, we report a semi-automated methodology aimed at streamlining the process of metabolic network reconstruction by enabling the integration of different genome-wide databases of metabolic reactions. …”
Publicado 2010
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7408por Leisner, Madeleine, Bleris, Leonidas, Lohmueller, Jason, Xie, Zhen, Benenson, Yaakov“…Here we show an alternative approach toward general-purpose control of mRNA and protein levels by logic integration of transcription factor input signals in mammalian cells. …”
Publicado 2010
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7409
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7410
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7413por Isokpehi, Raphael D, Rajnarayanan, Rajendram V, Jeffries, Cynthia D, Oyeleye, Tolulola O, Cohly, Hari HP“…We hypothesize that integrative analyses of protein sequences and body site expression of human, mouse, rat and chicken aquaporins has the potential to yield novel biological hypotheses about the unexpected cellular roles of aquaporins beyond transmembrane water transport. …”
Publicado 2009
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7414“…In-patient management with initial focus on weight restoration for an emaciated young girl with anorexia nervosa is reported. Integrative approach to management of this case yielded gratifying results which are maintained beyond one year after-discharge period.…”
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7416por Yeang, Chen-Hsiang“…Consequently, a computational model integrating multiple types of information is essential for the analysis of the comprehensive data. …”
Publicado 2010
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7418“…Current approaches of tumor classification using miRNA expression data do not integrate the experimental knowledge available in the literature. …”
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7419por Mehan, Michael R, Nunez-Iglesias, Juan, Dai, Chao, Waterman, Michael S, Zhou, Xianghong Jasmine“…To study the basis for these complex phenotypes, we developed a network-based approach to identify coexpression modules specifically activated in particular phenotypes. We integrated these modules, protein-protein interaction data, Gene Ontology annotations, and our database of gene-phenotype associations derived from literature to predict novel human gene-phenotype associations. …”
Publicado 2010
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7420por Childers, Christopher P., Reese, Justin T., Sundaram, Jaideep P., Vile, Donald C., Dickens, C. Michael, Childs, Kevin L., Salih, Hanni, Bennett, Anna K., Hagen, Darren E., Adelson, David L., Elsik, Christine G.“…The Bovine Genome Database (BGD; http://BovineGenome.org) strives to improve annotation of the bovine genome and to integrate the genome sequence with other genomics data. …”
Publicado 2011
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