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10821“…Results were similar when children with severe intellectual impairment were excluded. After adjusting for confounding factors, methadone-exposed children had increased odds of educational delay, but this was only marginally significant (OR = 3.62, [1.01–13.01], p = .049). …”
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10822por Waclawik, Kristina, Jones, Andrea A., Barbic, Skye P., Gicas, Kristina M., O'Connor, Tiffany A., Smith, Geoffrey N., Leonova, Olga, Mathias, Steve, Barr, Alasdair M., Procyshyn, Ric M., Lang, Donna J., Woodward, Melissa L., MacEwan, G. William, Panenka, William J., Yamamoto, Aiko, Honer, William G., Thornton, Allen E.“…Developmental and historical factors (premorbid intellectual functioning, neurological soft signs, earlier exposure to and longer duration of homelessness or marginal housing), as well as current health risks (stimulant dependence and hepatitis C exposure), were associated with cognitive impairment. …”
Publicado 2019
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10823por Gudmundsson, Olafur O., Walters, G. Bragi, Ingason, Andres, Johansson, Stefan, Zayats, Tetyana, Athanasiu, Lavinia, Sonderby, Ida Elken, Gustafsson, Omar, Nawaz, Muhammad S., Jonsson, Gudbjorn F., Jonsson, Lina, Knappskog, Per-Morten, Ingvarsdottir, Ester, Davidsdottir, Katrin, Djurovic, Srdjan, Knudsen, Gun Peggy Strømstad, Askeland, Ragna Bugge, Haraldsdottir, Gyda S., Baldursson, Gisli, Magnusson, Pall, Sigurdsson, Engilbert, Gudbjartsson, Daniel F., Stefansson, Hreinn, Andreassen, Ole A., Haavik, Jan, Reichborn-Kjennerud, Ted, Stefansson, Kari“…Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD), schizophrenia and ADHD. …”
Publicado 2019
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10824por Njue, Annete, Marguilis, Andrea, Lyall, Matthew, Nuabor, Weyinmi, Marks, Morgan, Russell, Kevin, Sinha, Anushua“…BACKGROUND: Congenitally transmitted cytomegalovirus (CMV) is the leading infectious cause of deafness and intellectual impairment among infants. Due to lack of effective preventive and curative treatments, routine CMV screening of pregnant women is generally not recommended by clinical guidelines or public health authorities, but is conducted on an opportunistic basis by specific healthcare systems and providers. …”
Publicado 2019
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10825“…The prevalence of associated NDDs was 16.8% (n = 103/612) in the study group, which consisted of epilepsy, intellectual disability (ID), autism spectrum disorders, Tourette syndrome (TS), attention deficit hyperactivity disorder, (ADHD), and others. …”
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10826por Srivastava, Siddharth, Love-Nichols, Jamie A., Dies, Kira A., Ledbetter, David H., Martin, Christa L., Chung, Wendy K., Firth, Helen V., Frazier, Thomas, Hansen, Robin L., Prock, Lisa, Brunner, Han, Hoang, Ny, Scherer, Stephen W., Sahin, Mustafa, Miller, David T.“…We defined NDD as global developmental delay, intellectual disability, and/or autism spectrum disorder. …”
Publicado 2019
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10827“…It is one of the major traditional practices in developing counties particularly in Ethiopia; which has significant physical, intellectual, psychological and emotional effects and reduces educational opportunities and the chance for personal growth for both boys and girls. …”
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10828por Guerrini, Christi J., Lewellyn, Meaganne, Majumder, Mary A., Trejo, Meredith, Canfield, Isabel, McGuire, Amy L.“…While most initiatives supported participants’ access to research outputs, including datasets and published findings, none supported participants’ control over results via intellectual property, licensing, or commercialization rights. …”
Publicado 2019
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10829por Locke, Warwick J., Guanzon, Dominic, Ma, Chenkai, Liew, Yi Jin, Duesing, Konsta R., Fung, Kim Y.C., Ross, Jason P.“…We discuss technical factors such as the analytical performance and product-market fit, factors that contribute to successful downstream investment, including geography, and how this impacts intellectual property, regulatory hurdles, and the future of the marketplace and healthcare system.…”
Publicado 2019
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10830por Misra, Shibalik, Peters, Greg, Barnes, Elizabeth, Ardern-Holmes, Simone, Webster, Richard, Troedson, Christopher, Mohammad, Shekeeb S., Gill, Deepak, Menezes, Manoj, Gupta, Sachin, Procopis, Peter, Antony, Jayne, Kurian, Manju A., Dale, Russell C.“…The combination of developmental delay/intellectual disability with dysmorphism and abnormal head circumference was also predictive for a pathogenic CNV (OR 2.86 [1.02–8.00]). …”
Publicado 2019
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10831por Li, Jinliang, Gao, Kai, Cai, Shuying, Liu, Yin, Wang, Yuzhen, Huang, Shaoping, Zha, Jian, Hu, Wenjing, Yu, Shujie, Yang, Zhixian, Xie, Han, Yan, Huifang, Wang, Jingmin, Wu, Ye, Jiang, Yuwu“…Variants in CSNK2B associated with epilepsy and/or intellectual disability (ID)/developmental delay (DD) have been reported in five cases only. …”
Publicado 2019
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10832por Baba, Masayuki, Yokoyama, Kazumasa, Seiriki, Kaoru, Naka, Yuichiro, Matsumura, Kensuke, Kondo, Momoka, Yamamoto, Kana, Hayashida, Misuzu, Kasai, Atsushi, Ago, Yukio, Nagayasu, Kazuki, Hayata-Takano, Atsuko, Takahashi, Akinori, Yamaguchi, Shun, Mori, Daisuke, Ozaki, Norio, Yamamoto, Tadashi, Takuma, Kazuhiro, Hashimoto, Ryota, Hashimoto, Hitoshi, Nakazawa, Takanobu“…3q29 microdeletion, a rare recurrent copy number variant (CNV), greatly confers an increased risk of psychiatric disorders, such as schizophrenia and autism spectrum disorder (ASD), as well as intellectual disability. However, disease-relevant cellular phenotypes of 3q29 deletion syndrome remain to be identified. …”
Publicado 2019
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10833por Middelkamp, Sjors, Vlaar, Judith M., Giltay, Jacques, Korzelius, Jerome, Besselink, Nicolle, Boymans, Sander, Janssen, Roel, de la Fonteijne, Lisanne, van Binsbergen, Ellen, van Roosmalen, Markus J., Hochstenbach, Ron, Giachino, Daniela, Talkowski, Michael E., Kloosterman, Wigard P., Cuppen, Edwin“…METHODS: We applied a combination of systematic experimental and bioinformatic methods to improve the molecular diagnosis of 39 patients with multiple congenital abnormalities and/or intellectual disability harboring apparent de novo SVs, most with an inconclusive diagnosis after regular genetic testing. …”
Publicado 2019
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10834por Gold, E. Richard, Ali-Khan, Sarah E., Allen, Liz, Ballell, Lluis, Barral-Netto, Manoel, Carr, David, Chalaud, Damien, Chaplin, Simon, Clancy, Matthew S., Clarke, Patricia, Cook-Deegan, Robert, Dinsmore, A. P., Doerr, Megan, Federer, Lisa, Hill, Steven A., Jacobs, Neil, Jean, Antoine, Jefferson, Osmat Azzam, Jones, Chonnettia, Kahl, Linda J., Kariuki, Thomas M., Kassel, Sophie N., Kiley, Robert, Kittrie, Elizabeth Robboy, Kramer, Bianca, Lee, Wen Hwa, MacDonald, Emily, Mangravite, Lara M., Marincola, Elizabeth, Mietchen, Daniel, Molloy, Jennifer C., Namchuk, Mark, Nosek, Brian A., Paquet, Sébastien, Pirmez, Claude, Seyller, Annabel, Skingle, Malcolm, Spadotto, S. Nicole, Staniszewska, Sophie, Thelwall, Mike“…Open science (OS) collaborations comprise of a subset of open practices including open access publication, open data sharing and the absence of restrictive intellectual property rights with which institutions, firms, governments and communities are experimenting in order to overcome these concerns. …”
Publicado 2019
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10835por Khan, Shazia, Rawlins, Lettie E., Harlalka, Gaurav V., Umair, Muhammad, Ullah, Asmat, Shahzad, Shaheen, Javed, Muhammad, Baple, Emma L., Crosby, Andrew H., Ahmad, Wasim, Gul, Asma“…MBOAT7 gene variants have recently been identified as a cause of intellectual disability (ID), seizures and autistic features. …”
Publicado 2019
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10836por Kolevzon, Alexander, Delaby, Elsa, Berry-Kravis, Elizabeth, Buxbaum, Joseph D., Betancur, Catalina“…Phelan-McDermid syndrome (PMS) is caused by haploinsufficiency of the SHANK3 gene on chromosome 22q13.33 and is characterized by intellectual disability, hypotonia, severe speech impairments, and autism spectrum disorder. …”
Publicado 2019
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10837por Avazzadeh, Sahar, McDonagh, Katya, Reilly, Jamie, Wang, Yanqin, Boomkamp, Stephanie D., McInerney, Veronica, Krawczyk, Janusz, Fitzgerald, Jacqueline, Feerick, Niamh, O’Sullivan, Matthew, Jalali, Amirhossein, Forman, Eva B., Lynch, Sally A., Ennis, Sean, Cosemans, Nele, Peeters, Hilde, Dockery, Peter, O’Brien, Timothy, Quinlan, Leo R., Gallagher, Louise, Shen, Sanbing“…NRXN1 deletion is among the commonest rare genetic factors shared by ASD, schizophrenia, intellectual disability, epilepsy, and developmental delay. …”
Publicado 2019
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10838por Grande, Antonio Jose, Ribeiro, Wagner Silva, Faustino, Christine, de Miranda, Claudio Torres, Mcdaid, David, Fry, Andra, de Moraes, Silvia Helena Mendonça, de Oliveira, Sandra Maria do Valle Leone, de Farias, Joni Marcio, de Tarso Coelho Jardim, Paulo, King, Derek, Silva, Valter, Ziebold, Carolina, Evans-Lacko, Sara“…Participants are 6 to 18 year-old children and adolescents who live in a LAMIC and who present with, or are at high risk of developing, one or more of the conditions: depression, anxiety, behavioural disorders, eating disorders, psychosis, substance abuse, autism and intellectual disabilities as defined by the DSM-V. Interventions which address suicide, self-harm will also be included, if identified during the extraction process. …”
Publicado 2020
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10839por Grossard, Charline, Dapogny, Arnaud, Cohen, David, Bernheim, Sacha, Juillet, Estelle, Hamel, Fanny, Hun, Stéphanie, Bourgeois, Jérémy, Pellerin, Hugues, Serret, Sylvie, Bailly, Kevin, Chaby, Laurence“…RESULTS: Using multivariate models including other factors known to predict FEs (age, gender, intellectual quotient, emotion subtype, cultural background), ratings from expert raters showed that children with ASD had more difficulty producing FEs than TD children. …”
Publicado 2020
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10840por Yan, Kezhi, Rousseau, Justine, Machol, Keren, Cross, Laura A., Agre, Katherine E., Gibson, Cynthia Forster, Goverde, Anne, Engleman, Kendra L., Verdin, Hannah, De Baere, Elfride, Potocki, Lorraine, Zhou, Dihong, Cadieux-Dion, Maxime, Bellus, Gary A., Wagner, Monisa D., Hale, Rebecca J., Esber, Natacha, Riley, Alan F., Solomon, Benjamin D., Cho, Megan T., McWalter, Kirsty, Eyal, Roy, Hainlen, Meagan K., Mendelsohn, Bryce A., Porter, Hillary M., Lanpher, Brendan C., Lewis, Andrea M., Savatt, Juliann, Thiffault, Isabelle, Callewaert, Bert, Campeau, Philippe M., Yang, Xiang-Jiao“…Moreover, we identify BRPF1 variants in 12 previously unidentified cases of syndromic intellectual disability and demonstrate that these cases and known BRPF1 variants impair H3K23 propionylation. …”
Publicado 2020
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