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  1. 5361
    “…ETHICS AND DISSEMINATION: Ethical approval for the study was granted by the Health Research Authority (reference: 20/HRA/210, IRAS: 282686) and local Trust Research and Development approval. …”
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    NHS CHECK: protocol for a cohort study investigating the psychosocial impact of the COVID-19 pandemic on healthcare workers
  2. 5362
    “…However, immune-related myocarditis (irM), an immune-mediated adverse event (irAE), is often fatal. In the absence of a reliable biomarker, measurement of pre-ICI therapy serum troponin concentration has been proposed to identify patients at risk of developing irM, although real-world studies examining this strategy are lacking. …”
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    Serum Troponin T Concentrations Are Frequently Elevated in Advanced Skin Cancer Patients Prior to Immune Checkpoint Inhibitor Therapy: Experience From a Single Tertiary Referral Center
  3. 5363
    “…Concurrently, an increasing number of neurological immune related adverse events (IRAE) has been observed. In this retrospective analysis, we examine the ICI-induced incidence of cerebral pseudoprogression and propose a classification system. …”
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    Immune Checkpoint Inhibitor-Induced Cerebral Pseudoprogression: Patterns and Categorization
  4. 5364
    “…ETHICS AND DISSEMINATION: The study has received the following approvals: Health Research Authority (IRAS 247388) and National Health Service Ethics Committee (19/LO/0557). …”
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    A feasibility study evaluating the uptake, effectiveness and acceptability of routine screening of pregnant migrants for latent tuberculosis infection in antenatal care: a research protocol
  5. 5365
    “…Gender, age, smoking history, PD-L1 TPS expression, history of targeted therapy and irAEs all had a degree of influence on patient prognosis. …”
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    Real-World Data of Different Immune Checkpoint Inhibitors for Non-Small Cell Lung Cancer in China
  6. 5366
    “…However, these treatments result in serious immune-related adverse events (irAEs) owning to systemic immune activation. Therefore, to achieve long-term therapeutic effects and low side effects, it is necessary to find drugs inhibiting the local PD-1/PD-L1 signaling pathway of the TME. …”
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    Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8(+) T Cells in Local Tumor Microenvironment
  7. 5367
    “…However, ICI therapy has also been associated with various immune-related adverse events (irAEs), especially for patients with preexisting autoimmune status, which sometimes can be life-threatening. …”
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    Camrelizumab-Related Lethal Arrhythmias and Myasthenic Crisis in a Patient with Metastatic Thymoma
  8. 5368
    “…ETHICS AND DISSEMINATION: This study protocol achieved National Health Service Research Ethics Committee (NHS REC), London—Hampstead Research Ethics Committee approval (IRAS 217422). Our findings will be disseminated via conference presentations and peer-reviewed publications. …”
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    METRIC-EF: magnetic resonance enterography to predict disabling disease in newly diagnosed Crohn’s disease—protocol for a multicentre, non-randomised, single-arm, prospective study
  9. 5369
    “…ETHICS AND DISSEMINATION: The protocol has been approved by the research ethics committees of Newcastle University and the Health Research Authority (HRA) of the UK (ethical approval IRAS ID 305302). Findings will be published in peer-reviewed journals and presented at national and international conferences. …”
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    Body surface gastric mapping to determine gastric motility patterns associated with delayed gastric emptying after pancreaticoduodenectomy. Gastric Electric Mapping after Pancreatoduodenectomy study protocol
  10. 5370
    “…ETHICS AND DISSEMINATION: NHS REC Approval has been granted (IRAS ID 314705). Study participation is voluntary; participants will be provided with all necessary information within the participant information sheet, with written consent being sought. …”
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    Is fear of falling key to identifying gait and balance abnormalities in community-dwelling older adults? Protocol of a mixed-methods approach
  11. 5371
    “…ETHICS AND DISSEMINATION: Ethical approval has been granted (IRAS 209815) and RISC-sepsis is registered with the ISRCTN (86837685). …”
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    Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use: protocol for an observational study (RISC-sepsis)
  12. 5372
    “…However, inherent disadvantages of immune checkpoint inhibitors (ICIs), such as their low response rates and immune‐related adverse events (irAEs), currently restrict their clinical application. …”
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    Hyperthermia combined with immune checkpoint inhibitor therapy: Synergistic sensitization and clinical outcomes
  13. 5373
    “…One low-grade TrAE, alanine aminotransferase increased (vorinostat + pembrolizumab related), was an irAE and correlated with worse OS in Cohort A. Conclusions: The study demonstrated the potential clinical utility of early AE-derived biomarkers in predicting positive and negative clinical outcomes. …”
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    Early Adverse Event Derived Biomarkers in Predicting Clinical Outcomes in Patients with Advanced Non-Small Cell Lung Cancer Treated with Immunotherapy
  14. 5374
    por Rabbers, Iraes, Bruggeman, Frank J.
    Publicado 2022
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    Escherichia coli robustly expresses ATP synthase at growth rate‐maximizing concentrations
  15. 5375
    “…ETHICS AND DISSEMINATION: The study has received research ethics committee approval from the Yorkshire and Humber Leeds West Research Ethics Committee 2 (reference 20/YH/0214; IRAS reference 250612). Submission of study results for publication will involve making available all anonymised primary and processed data on public repository sites. …”
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    Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study
  16. 5376
    “…Autoantibodies have the potential as cancer biomarkers as they may associate with the outcome and immune-related adverse events (irAEs) following immunotherapy. Cancer and other fibroinflammatory diseases, such as rheumatoid arthritis (RA), are associated with excessive collagen turnover leading to collagen triple helix unfolding and denaturation with exposure of immunodominant epitopes. …”
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    Autoreactivity against Denatured Type III Collagen Is Significantly Decreased in Serum from Patients with Cancer Compared to Healthy Controls
  17. 5377
    “…Background: The increasing use of immune checkpoint inhibitors (ICIs) in the treatment of both advanced and early stages of various malignancies has resulted in a substantial increase in the incidence of cardiovascular (CV) immune-related adverse events (irAEs). The current follow-up guidelines are based on anecdotal evidence and expert opinions, due to a lack of solid data and prospective studies. …”
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    Extensive CArdioVAscular Characterization and Follow-Up of Patients Receiving Immune Checkpoint Inhibitors: A Prospective Multicenter Study
  18. 5378
    “…However, the use of ICIs also induces a series of adverse reactions similar to autoimmune reactions, called immune-related adverse events (irAEs). Some ICIs can cause manifestations similar to those in the development of sarcoidosis, which are called sarcoidosis-like reactions or granulomatosis. …”
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    Pulmonary sarcoidosis-like reactions induced by sintilimab in esophageal cancer: A case report
  19. 5379
    “…ETHICS AND DISSEMINATION: Ethics approval was obtained from Wales Research Ethics Committee 1 (IRAS ID 312494) and study approval from the Health Research Authority (22/WA/0087). …”
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    CompreHensive geriAtRician-led MEdication Review (CHARMER): protocol for a feasibility study of a hospital deprescribing behaviour change intervention
  20. 5380
    por Gbinigie, Oghenekome, Ogburn, Emma, Allen, Julie, Dorward, Jienchi, Dobson, Melissa, Madden, Tracie-Ann, Yu, Ly-Mee, Lowe, David M, Rahman, Najib, Petrou, Stavros, Richards, Duncan, Hood, Kerenza, Patel, Mahendra, Saville, Benjamin R, Marion, Joe, Holmes, Jane, Png, May Ee, Hayward, Gail, Lown, Mark, Harris, Victoria, Jani, Bhautesh, Hart, Nigel, Khoo, Saye, Rutter, Heather, Chalk, Jem, Standing, Joseph F, Breuer, Judith, Lavallee, Layla, Hadley, Elizabeth, Cureton, Lucy, Benysek, Magdalena, Andersson, Monique I, Francis, Nick, Thomas, Nicholas P B, Evans, Philip, van Hecke, Oliver, Koshkouei, Mona, Coates, Maria, Barrett, Sarah, Bateman, Clare, Davies, Jennifer, Raymundo-Wood, Ivy, Ustianowski, Andrew, Nguyen-Van-Tam, Jonathan, Carson-Stevens, Andrew, Hobbs, Richard, Little, Paul, Butler, Christopher C
    Publicado 2023
    “…ETHICS AND DISSEMINATION: Ethical approval granted by South Central–Berkshire REC number: 21/SC/0393; IRAS project ID: 1004274. Results will be presented to policymakers and at conferences, and published in peer-reviewed journals. …”
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    Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease
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