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  1. 5421
    “…ETHICS AND DISSEMINATION: Ethical and health research authority approvals have been granted (IRAS Project ID: 302251; REC reference number 22/SS/0004). …”
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    Surgical-PEARL protocol: a multicentre prospective cohort study exploring aetiology, management and outcomes for patients with congenital anomalies potentially requiring surgical intervention
  2. 5422
    por Abergel, A, Ade, P A R, Aghanim, N, Alina, D, Alves, M I R, Armitage-Caplan, C, Arnaud, M, Ashdown, M, Atrio-Barandela, F, Aumont, J, Baccigalupi, C, Banday, A J, Barreiro, R B, Bartlett, J G, Battaner, E, Benabed, K, Benoît, A, Benoit-Lévy, A, Bernard, J -P, Bersanelli, M, Bielewicz, P, Bobin, J, Bock, J J, Bonaldi, A, Bond, J R, Borrill, J, Bouchet, F R, Boulanger, F, Bridges, M, Bucher, M, Burigana, C, Butler, R C, Cardoso, J -F, Catalano, A, Chamballu, A, Chary, R -R, Chiang, H C, Chiang, L -Y, Christensen, P R, Church, S, Clemens, M, Clements, D L, Colombi, S, Colombo, L P L, Combet, C, Couchot, F, Coulais, A, Crill, B P, Curto, A, Cuttaia, F, Danese, L, Davies, R D, Davis, R J, de Bernardis, P, de Rosa, A, de Zotti, G, Delabrouille, J, Delouis, J -M, Désert, F -X, Dickinson, C, Diego, J M, Dole, H, Donzelli, S, Doré, O, Douspis, M, Dupac, X, Efstathiou, G, Enßlin, T A, Eriksen, H K, Falgarone, E, Finelli, F, Forni, O, Frailis, M, Fraisse, A A, Franceschi, E, Galeotta, S, Ganga, K, Ghosh, T, Giard, M, Giardino, G, Giraud-Héraud, Y, González-Nuevo, J, Górski, K M, Gratton, S, Gregorio, A, Grenier, I A, Gruppuso, A, Guillet, V, Hansen, F K, Hanson, D, Harrison, D, Helou, G, Henrot-Versillé, S, Hernández-Monteagudo, C, Herranz, D, Hildebrandt, S R, Hivon, E, Hobson, M, Holmes, W A, Hornstrup, A, Hovest, W, Huffenberger, K M, Jaffe, A H, Jaffe, T R, Jewell, J, Joncas, G, Jones, W C, Juvela, M, Keihänen, E, Keskitalo, R, Kisner, T S, Knoche, J, Knox, L, Kunz, M, Kurki-Suonio, H, Lagache, G, Lähteenmäki, A, Lamarre, J -M, Lasenby, A, Laureijs, R J, Lawrence, C R, Leonardi, R, León-Tavares, J, Lesgourgues, J, Levrier, F, Liguori, M, Lilje, P B, Linden-Vørnle, M, López-Caniego, M, Lubin, P M, Macías-Pérez, J F, Maffei, B, Maino, D, Mandolesi, N, Maris, M, Marshall, D J, Martin, P G, Martínez-González, E, Masi, S, Massardi, M, Matarrese, S, Matthai, F, Mazzotta, P, McGehee, P, Melchiorri, A, Mendes, L, Mennella, A, Migliaccio, M, Mitra, S, Miville-Deschênes, M -A, Moneti, A, Montier, L, Morgante, G, Mortlock, D, Munshi, D, Murphy, J A, Naselsky, P, Nati, F, Natoli, P, Netterfield, C B, Nørgaard-Nielsen, H U, Noviello, F, Novikov, D, Novikov, I, Osborne, S, Oxborrow, C A, Paci, F, Pagano, L, Pajot, F, Paladini, R, Paoletti, D, Pasian, F, Patanchon, G, Perdereau, O, Perotto, L, Perrotta, F, Piacentini, F, Piat, M, Pierpaoli, E, Pietrobon, D, Plaszczynski, S, Pointecouteau, E, Polenta, G, Ponthieu, N, Popa, L, Poutanen, T, Pratt, G W, Prézeau, G, Prunet, S, Puget, J -L, Rachen, J P, Reach, W T, Rebolo, R, Reinecke, M, Remazeilles, M, Renault, C, Ricciardi, S, Riller, T, Ristorcelli, I, Rocha, G, Rosset, C, Roudier, G, Rowan-Robinson, M, Rubiño-Martín, J A, Rusholme, B, Sandri, M, Santos, D, Savini, G, Scott, D, Seiffert, M D, Shellard, E P S, Spencer, L D, Starck, J -L, Stolyarov, V, Stompor, R, Sudiwala, R, Sunyaev, R, Sureau, F, Sutton, D, Suur-Uski, A -S, Sygnet, J -F, Tauber, J A, Tavagnacco, D, Terenzi, L, Toffolatti, L, Tomasi, M, Tristram, M, Tucci, M, Tuovinen, J, Türler, M, Umana, G, Valenziano, L, Valiviita, J, Van Tent, B, Vielva, P, Villa, F, Vittorio, N, Wade, L A, Wandelt, B D, Welikala, N, Yvon, D, Zacchei, A, Zonca, A
    Publicado 2013
    “…This paper presents an all-sky model of dust emission from the Planck 857, 545 and 353 GHz, and IRAS 100 micron data. Using a modified black-body fit to the data we present all-sky maps of the dust optical depth, temperature, and spectral index over the 353-3000 GHz range. …”
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    Planck 2013 results. XI. All-sky model of thermal dust emission
  3. 5423
    “…However, clinical responses to various immune checkpoint inhibitors are often accompanied by immune-related adverse events (irAEs). Therefore, it is crucial to obtain a comprehensive understanding of the association between different immune tumor microenvironments (TMEs) and the immunotherapeutic response. …”
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    Exploration of prognostic biomarkers in head and neck squamous cell carcinoma microenvironment from TCGA database
  4. 5424
    “…BACKGROUND: Immune checkpoint inhibitors (ICIs), antibodies targeting PD-1/PD-L1 or CTLA4 have revolutionized cancer management but are associated with devastating immune-related adverse events (irAEs) including myocarditis. The main risk factor for ICI myocarditis is the use of combination PD-1 and CTLA4 inhibition. …”
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    Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis
  5. 5425
    “…TRIAL REGISTRATION: National Institute of Health Research Clinical Research Network portfolio IRAS ID: 272,250. Health Research Authority approval 18 October 2019. …”
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    Implementation of a batched stepped wedge trial evaluating a quality improvement intervention for surgical teams to reduce anastomotic leak after right colectomy
  6. 5426
    “…TRIAL REGISTRATION: CICATRIx IRAS number 198179, 14 Dec 2015, https://www.myresearchproject.org.uk/. …”
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    Development of a dual energy CT based model to assess response to treatment in patients with high grade serous ovarian cancer: a pilot cohort study
  7. 5427
    “…SUPPORT/SOURCE: National Institute for Health and Care Research (NIHR) - Research for Patient Benefit Programme (IRAS ID 297420).…”
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    O.2.2-6 ‘Let’s Ask the Service Users and Staff!’ - Barriers and Facilitators to Increasing Physical Activity in Medium Secure Psychiatric Services in the UK?
  8. 5428
    “…High-grade immune-related adverse events (irAEs) occur in a significant number of patients (5-15%, cancer- and therapeutic-dependent) that can lead to lifelong issues and can exclude from treatment patients with pre-existing autoimmune diseases. …”
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    Refined control of CRISPR-Cas9 gene editing in Clostridium sporogenes: the creation of recombinant strains for therapeutic applications
  9. 5429
    “…ETHICS AND DISSEMINATION: The trial was approved by an ethics committee (Solihull Research Ethics Committee, 30 June 2021, IRAS: 295831). Participants will provide informed consent before agreeing to participate. …”
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    UK robotic arthroplasty clinical and cost effectiveness randomised controlled trial for hips (RACER-Hip): a study protocol
  10. 5430
    “…ETHICS AND DISSEMINATION: HABSelect is a UK NIHR-EME funded study (reg no 11/14/34; IRAS REF. 13/YH/0162). The trial was designed in partnership with patient and public involvement to help maximise patient benefits. …”
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    Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial
  11. 5431
    “…Immunotherapy safety profile is advantageous, although, in contrast to conventional chemotherapy: boosting the immune system leads to a unique constellation of inflammatory toxicities known as immune-related Adverse Events (irAEs) that may warrant the discontinuation of therapy and/or the administration of immunosuppressive agents. …”
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    Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge”, Napoli, November 30th 2016
  12. 5432
    “…A favourable opinion was granted by the Wales Research Ethics Committee (16/WA/0225), study-wide NHS approval was given by the Health Research Authority (IRAS 206745), and participating NHS trusts provided local approvals. …”
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    Trial of Acute Femoral Fracture Fixation (TrAFFix): study protocol for a randomised controlled feasibility trial
  13. 5433
    “…A spectrum of immune related adverse events (irAEs) involving the skin can occur and include immunobullous disorders, lichenoid dermatitis, and vitiligo. …”
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    Granulomatous/sarcoid-like lesions associated with checkpoint inhibitors: a marker of therapy response in a subset of melanoma patients
  14. 5434
    “…ETHICS AND DISSEMINATION: This study was approved by South West–Frenchay Research Ethics Committee (REC reference: 17/SW/0033; IRAS ID: 220631) and the Health Research Authority (HRA). …”
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    Drug use in street sex workers (DUSSK) study protocol: a feasibility and acceptability study of a complex intervention to reduce illicit drug use in drug-dependent female street sex workers
  15. 5435
    “…However, ICB immunotherapy also triggers severe inflammatory side effects, known as immune-related adverse effects (irAEs). One of the most common toxicities is immune checkpoint blockade-associated colitis (ICB associated colitis). …”
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    Probiotics Lactobacillus reuteri Abrogates Immune Checkpoint Blockade-Associated Colitis by Inhibiting Group 3 Innate Lymphoid Cells
  16. 5436
    “…ASSERT was approved and sponsored by Nottingham University Hospitals NHS Trust (reference 18HC001) and the Health Research Authority (reference IRAS 232791). Recruitment is ongoing. Results will be presented at relevant conferences and submitted to appropriate journals on study completion. …”
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    ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation) randomised controlled, feasibility in older people trial: a study protocol
  17. 5437
    “…ETHICS AND DISSEMINATION: Research ethics approval has been obtained (IRAS 212304). Dissemination will be through publication of findings and development of recommendations for care. …”
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    Optimising neonatal service provision for preterm babies born between 27 and 31 weeks gestation in England (OPTI-PREM), using national data, qualitative research and economic analysis: a study protocol
  18. 5438
    “…BACKGROUND: Immune checkpoint inhibitors (CPIs) have revolutionized oncologic therapy but can lead to immune‐related adverse events (irAEs). Corticosteroids are first‐line treatment with escalation to biologic immunosuppression in refractory cases. …”
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    Colitis after checkpoint blockade: A retrospective cohort study of melanoma patients requiring admission for symptom control
  19. 5439
    “…ETHICS AND DISSEMINATION: Research Ethics Committee, Yorkshire and Humber Sheffield Research Ethics Committee UK (Ref: 19/YH/0143) and Health Research Authority (IRAS reference 254466, EDGE ID: 123146) approval received on 17/07/2019. …”
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    MAGNETO cardiography parameters to predict future Sudden Cardiac Death (MAGNETO-SCD) or ventricular events from implantable cardioverter defibrillators: study protocol, design and rationale
  20. 5440
    “…PPI network construction revealed that the top 10 hub genes—ACLY, HSPD1, PFAS, GART, TXN, HSPH1, HSPE1, IRAS, TRAP1, and ATIC—might be associated with tamoxifen resistance. …”
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    Identification and characterization of critical genes associated with tamoxifen resistance in breast cancer
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