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5461por Wallace, Sarah, Hall, Victoria, Charlett, Andre, Kirwan, Peter D, Cole, Michele, Gillson, Natalie, Atti, Ana, Timeyin, Jean, Foulkes, Sarah, Taylor-Kerr, Andrew, Andrews, Nick, Shrotri, Madhumita, Rokadiya, Sakib, Oguti, Blanche, Vusirikala, Amoolya, Islam, Jasmin, Zambon, Maria, Brooks, Tim J G, Ramsay, Mary, Brown, Colin S, Chand, Meera, Hopkins, Susan“…ETHICS AND DISSEMINATION: The study was approved by the Berkshire Research Ethics Committee, Health Research Authority (IRAS ID 284460, REC reference 20/SC/0230) on 22 May 2020; the vaccine amendment was approved on 12 January 2021. …”
Publicado 2022
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5462por Tsang, Kevin Cheuk Him, Pinnock, Hilary, Wilson, Andrew M, Salvi, Dario, Shah, Syed Ahmar“…ETHICS AND DISSEMINATION: Ethics approval was provided by the East of England - Cambridge Central Research Ethics Committee. IRAS project ID: 285 505 with governance approval from ACCORD (Academic and Clinical Central Office for Research and Development), project number: AC20145. …”
Publicado 2022
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5463por Noble, Adam J, Mason, Suzanne M, Bonnett, Laura J, Reuber, Markus, Wright, Jasmine, Pilbery, Richard, Jacques, Richard M, Simpson, Rebecca M, Campbell, Richard, Fuller, Alison, Marson, Anthony Guy, Dickson, Jon Mark“…ETHICS AND DISSEMINATION: WP1a and WP2 will be conducted under database ethical approval (IRAS 307353) and Confidentiality Advisory Group (22/CAG/0019) approval. …”
Publicado 2022
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5464“…ETHICS AND DISSEMINATION: This study has received Teesside University ethical approval, Health Research Authority approval (IRAS: 310622) and favourable opinion (REF: 22/PR/0793). …”
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5465por Pedlow, Katy, McDonough, Suzanne, Klempel, Natalie, Hylands, Jenny, Hughes, Noelene, Campbell, Zoe, Eng, Janice J, Stephenson, Aoife, Kennedy, Niamh“…ETHICS AND DISSEMINATION: This study has been approved by the Health and Social Care Research Ethics Committee A, IRAS project ID (278620). Participants will provide informed consent prior to participating in the study. …”
Publicado 2023
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5466por Ma, Ji, Yao, Nan, Lu, Jiaying, Qu, Wanxi, Cui, Li, Yuan, Shiwang, Li, Na, Tong, Shaodong, Qin, Zhaohui, Yao, Yuanhu“…Primary outcomes of interest were progression-free survival (PFS) and overall survival (OS); secondary outcomes were objective response rate (ORR), disease control rate (DCR), duration of response (DoR), and treatment-related adverse events (AEs) including immune-related adverse events (irAEs). RESULTS: At data cutoff, 81 patients were included (30 Anti-PD-1+CRT, 51 CRT). …”
Publicado 2023
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5467por Meijboom, Rozanna, Wiseman, Stewart J., York, Elizabeth N., Bastin, Mark E., Valdés Hernández, Maria del C., Thrippleton, Michael J., Mollison, Daisy, White, Nicole, Kampaite, Agniete, Ng Kee Kwong, Koy, Rodriguez Gonzalez, David, Job, Dominic, Weaver, Christine, Kearns, Patrick K. A., Connick, Peter, Chandran, Siddharthan, Waldman, Adam D.“…FutureMS is registered with the Integrated Research Application System (IRAS, UK) under reference number 169955. Methods and analysis: MRI is performed at baseline (N=431) and 1-year follow-up, in Dundee, Glasgow and Edinburgh (3T Siemens) and in Aberdeen (3T Philips), and managed and processed in Edinburgh. …”
Publicado 2022
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5468por Trommer, Maike, Adams, Anne, Celik, Eren, Fan, Jiaqi, Funken, Dominik, Herter, Jan M., Linde, Philipp, Morgenthaler, Janis, Wegen, Simone, Mauch, Cornelia, Franklin, Cindy, Galldiks, Norbert, Werner, Jan-Michael, Kocher, Martin, Rueß, Daniel, Ruge, Maximilian, Meißner, Anna-Katharina, Baues, Christian, Marnitz, Simone“…In concurrently treated patients, treatment response (LC) was delayed and specific immune responses (AbE, PsP, IrAE) occurred more frequently with longer OS rates. …”
Publicado 2022
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5469por Foley, Éimear M, Griffiths, Sian Lowri, Murray, Alexander, Rogers, Jack, Corsi-Zuelli, Fabiana, Hickinbotham, Hannah, Warwick, Ella, Wilson, Martin, Kaser, Muzaffer, Murray, Graham K, Deakin, Bill, Jadon, Deepak, Suckling, John, Barnes, Nicholas M, Upthegrove, Rachel, Khandaker, Golam M“…ETHICS AND DISSEMINATION: The study is sponsored by the University of Bristol and has been approved by the Cambridge East Research Ethics Committee (reference: 22/EE/0010; IRAS project ID: 301682). Study findings will be published in peer-review journals. …”
Publicado 2023
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5470“…The study was restricted to original articles investigating ICI-induced cardiac immune-related adverse events (irAEs). The targeted population was cancer patients treated with either pembrolizumab or nivolumab monotherapy, of which those with records of any cardiac events following the therapy were labeled as events. …”
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5471“…The patient started a second course of ImT with nivolumab and ipilimumab, but this was discontinued after two cycles due to an immune-related adverse event (irAE, hepatitis with elevated liver enzymes). Interval imaging identified visceral and osseous metastases including multiple lesions in the liver and in the lumbar spine. …”
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5472por Deng, Ting, Li, Danyang, Yang, Yuchong, Wang, Feixue, Bai, Ming, Liu, Rui, Li, Hongli, Ba, Yi“…Median DoR was not reached in cohort A and it was 16.3 (95% CI, 8.453–24.207) months in cohort B (p = 0.141). The most common irAEs were grade 1 hypothyroidism (33.3%) in cohort A. …”
Publicado 2023
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5473“…Introduction: Cutaneous adverse events are commonly reported immune-related adverse events (irAEs), some of which are serious or even life-threatening, and it is essential to study these specific cutaneous AEs to understand their characteristics and risk. …”
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5474por Zhang, Zhengfeng, Wang, Dazhen, Yang, Liu, Zhao, Lu, Yang, Lei, Zhang, Jianji, Lou, Changjie“…For the treatment‐related adverse events (TRAEs), the highest grade 3–4 adverse effects were thrombocytopenia in 7.75% (10/129) and neutropenia in 3.1% (4/129), immune‐related adverse events (irAEs) occurred in 32.8% (21/64), and all were grade 1–2. …”
Publicado 2023
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5475por Barber, Vicki S, Peckham, Nicholas, Duley, Lelia, Francis, Anne, Abhishek, Abhishek, Moss, Paul, Cook, Jonathan A, Parry, Helen M“…ETHICS AND DISSEMINATION: This study has been approved by Leeds East Research Ethics Committee and Health Research Authority (REC Reference:22/YH/0226, IRAS ID: 319057). Dissemination will be via peer-review publications, newsletters and conferences. …”
Publicado 2023
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5476por Smith, Jason E., Barnard, Ed B. G., Brown-O’Sullivan, Charlie, Cardigan, Rebecca, Davies, Jane, Hawton, Annie, Laing, Emma, Lucas, Joanne, Lyon, Richard, Perkins, Gavin D., Smith, Laura, Stanworth, Simon J., Weaver, Anne, Woolley, Tom, Green, Laura“…TRIAL REGISTRATION: ISRCTN: 23657907; EudraCT: 2021-006876-18; IRAS Number: 300414; REC: 22/SC/0072, 21 Dec 2021.…”
Publicado 2023
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5477por Connelly, Jessica J, Shah, Svati H, Doss, Jennifer F, Gadson, Shera, Nelson, Sarah, Crosslin, David R, Hale, A Brent, Lou, Xuemei, Wang, Ty, Haynes, Carol, Seo, David, Crossman, David C, Mooser, Vincent, Granger, Christopher B, Jones, Christopher JH, Kraus, William E, Hauser, Elizabeth R, Gregory, Simon G“…This peak overlaps a recently identified inflammatory biomarker (MCP-1) linkage region from the Framingham Heart Study (maximum LOD of 4.27, D1S1589) and a region of linkage to metabolic syndrome from the IRAS study (maximum LOD of 2.59, D1S1589/D1S518). …”
Publicado 2008
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5478por Noyes, Jane, Morgan, Karen, Walton, Phillip, Roberts, Abigail, Mclaughlin, Leah, Stephens, Michael“…ETHICS AND DISSEMINATION: Approved by NHSBT Research, Innovation and Technology Advisory Group on 23 October 2015; Wales Research Ethics Committee 5 (IRAS190066; Rec Reference 15/WA/0414) on 25 November 2015 and NHSBT R&D Committee (NHSBT ID: AP-15–02) on 24 November 2015. …”
Publicado 2017
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5479“…However, their use is complicated by immune-related adverse events (irAEs), including endocrine adverse events (eAEs). …”
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5480por Li, Jie, Li, Zhonghu, Jiang, Peng, Peng, Minjie, Zhang, Xi, Chen, Kai, Liu, Hui, Bi, Huaqiang, Liu, Xiangde, Li, Xiaowu“…Overexpression of circ-IARS significantly down-regulated miR-122 and ZO-1 levels, up-regulated RhoA and RhoA-GTP levels, increased F-actin expression and focal adhesion, enhanced endothelial monolayer permeability, and promoted tumor invasion and metastasis. CONCLUSIONS: circ-IRAS accesses HUVECs via exosomes derived from pancreatic cancer cells followed by increased endothelial monolayer permeability. …”
Publicado 2018
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