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  1. 15141
    “…Methods: This study retrospectively analyses the real-world clinical practice with full and attenuated doses of FOLFIRINOX in unselected patients with locally advanced unresectable or metastatic pancreatic cancer, treated at an Italian general hospital. Efficacy, tolerability, and toxicity were evaluated, and overall survival (OS) and progression-free survival (PFS) were estimated by Kaplan–Meier method. …”
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    Modified FOLFIRINOX for unresectable locally advanced/metastatic pancreatic cancer. A real-world comparison of an attenuated with a full dose in a single center experience
  2. 15142
    “…The aim of this small volume is to raise awareness among Italian hematologists using hypomethylating drugs about risk - and even more important about “risk management” - and the treatment of the infectious events that may arise during therapy with these drugs. …”
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    Risk of infection in elderly patients with AML and MDS treated with hypomethylating agents
  3. 15143
    “…In the frame of the VITA mission of the Italian Space Agency (ASI), we addressed the problem of Space osteoporosis by using human blood-derived stem cells (BDSCs) as a suitable osteogenic differentiation model. …”
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    Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosis
  4. 15144
    “…We investigated its relevance in the context of the Italian health care system. In this study, the relationship between sources of stress at work and its outcomes in terms of psychological and physical health are explored. …”
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    Psychological Flexibility and Mindfulness as Predictors of Individual Outcomes in Hospital Health Workers
  5. 15145
    “…METHODS: We reviewed the current evidence on the drug safety of targeted agents for metastatic breast cancer currently used in clinical practice in Italy, supported by the clinical experience of Italian oncologists with expertise in the field. RESULTS: All oncologists had used CDK4/6 inhibitors in clinical practice and/or within a clinical trial. …”
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    Management of toxicities associated with targeted therapies for HR-positive metastatic breast cancer: a multidisciplinary approach is the key to success
  6. 15146
    “…Aim of the present study is to describe co-morbidity and multi-morbidity, their clustering mode and the potential disease-disease interactions in a cohort of Italian HIV patients. METHODS: Cross-sectional analysis conducted by the Coordinamento Italiano per lo Studio di Allergia e Infezioni da HIV (CISAI) on adult subjects attending HIV-outpatient facilities. …”
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    Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study
  7. 15147
    “…We reveal the enigmatic origin of one of the earliest surviving botanical collections. The 16(th)-century Italian En Tibi herbarium is a large, luxurious book with c. 500 dried plants, made in the Renaissance scholarly circles that developed botany as a distinct discipline. …”
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    Breaking the silence of the 500-year-old smiling garden of everlasting flowers: The En Tibi book herbarium
  8. 15148
    “…A questionnaire was filled in by 3,602 students from Italian Lower Secondary Schools and Upper Secondary Schools. …”
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    Young, Bullying, and Connected. Common Pathways to Cyberbullying and Problematic Internet Use in Adolescence
  9. 15149
    “…Aim: Studies have shown that Lactobacilli reuteri probiotics can affect cells that play a key role in the immune system. This in vivo Italian study investigated how Lactobacillus reuteri DSM 17938 influenced CC-chemokine receptor 7 (CCR7) and interleukin 10 (IL-10) in breastfed colicky infants. …”
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    Lactobacillus reuteri DSM 17938 Probiotics May Increase CC-Chemokine Receptor 7 Expression in Infants Treated With for Colic
  10. 15150
    “…METHODS: Following PRISMA guidelines, we performed an unlimited search for articles on CH in the MEDLINE (PubMed), EMBASE, Cochrane, Latindex and Scielo databases, published in English, Spanish, French, German or Italian between January 1, 1960 and December 15, 2018. …”
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    Hydatid cyst of the colon: A systematic review of the literature
  11. 15151
    “…METHODS: Information on more than half a million cancer patients aged 15‐74 years collected by population‐based Italian cancer registries and mixture cure models were used to estimate the life expectancy of fatal tumors (LEFT), proportions of patients with similar death rates of the general population (cure fraction), and time to reach 5‐year conditional relative survival (CRS) >90% or 95% (time to cure). …”
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    Prognosis and cure of long‐term cancer survivors: A population‐based estimation
  12. 15152
    “…METHODS: Observational study in a tertiary care Italian public hospital during a 10-year period. To identify severe obstetric complications, the following management-based criteria were adopted: need for intensive care unit admission, blood transfusion ≥5 units, emergency peripartum hysterectomy/laparotomy and arterial embolization. …”
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    Perinatal outcome of severe obstetric complications: findings of a 10-year hospital-based surveillance study in Italy
  13. 15153
    “…The highest and lowest prevalence of sexual dysfunction was 94.4% in Iranian women with type 2 diabetes (95% CI 91.9%–96.3%) in 2014 and 17% in Italian women with diabetes Type 2 (95% CI 6.4–36.9%) in 2015. …”
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    Evaluation of sexual dysfunction and female sexual dysfunction indicators in women with type 2 diabetes: a systematic review and meta-analysis
  14. 15154
    “…MATERIALS AND METHODS: Patients who underwent EUS-guided tissue acquisition with the 20G PC needle of pancreatic and extra-pancreatic mass lesions were retrospectively identified at three Italian centers (Bologna, Fermo, and Palermo). Diagnostic adequacy, accuracy, and tissue core acquisition were the outcome measures. …”
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    High diagnostic adequacy and accuracy of the new 20G procore needle for EUS-guided tissue acquisition: Results of a large multicentre retrospective study
  15. 15155
    “…In order to differentiate the extra virgin olive oils (EVOO) of different origin of purchase, such as monovarietal Italian EVOO with protected denomination of origin (PDO) and commercial-blended EVOO purchased in supermarkets, a number of samples was subjected to the analysis of volatile aroma compounds by both targeted gas chromatography/mass spectrometry (GC-MS) and untargeted profiling by comprehensive two-dimensional gas chromatography/mass spectrometry (GC×GC-TOF-MS), analysis of phenols by targeted high-performance liquid chromatography/mass spectrometry (HPLC-DAD-ESI/MS), and quantitative descriptive sensory analysis. …”
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    Complementary Untargeted and Targeted Metabolomics for Differentiation of Extra Virgin Olive Oils of Different Origin of Purchase Based on Volatile and Phenolic Composition and Sensory Quality
  16. 15156
    “…This study aimed to assess the inter-rater reliability of the HEART score calculated by a large number of Italian emergency physicians. METHODS: The study was conducted in three academic emergency departments using clinical scenarios obtained from medical records of patients with chest pain. …”
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    Multicenter observational study on the reliability of the HEART score
  17. 15157
    “…METHODS: Public data of Italian Institute for Statistics (ISTAT) and available scientific reports were reviewed and findings integrated. …”
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    Urban diabetes: the case of the metropolitan area of Rome
  18. 15158
    “…The aim of this study was to attempt to have a better insight into the trends of MDR-TB in the metropolitan area of Rome, within the Italian and the foreign-born population, based on microbiological and demographic data. …”
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    Multidrug-Resistant Tuberculosis In A Referral Center In Rome: 2011– 2016
  19. 15159
    “…A cohort longitudinal study was conducted on 161 Italian nulliparous low-risk women (M(age) = 31.63; SD = 4.88) without elective cesarean. …”
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    A Comprehensive Analysis of Post-partum Depression Risk Factors: The Role of Socio-Demographic, Individual, Relational, and Delivery Characteristics
  20. 15160
    “…FRAILSURVEY, which was considered a good practice by several entities, is a smartphone application that allows an easy assessment of frailty, available in Portuguese, English and Italian, on both iOS and Android stores. Smartphone-based assessment has been proven to be a useful diagnostic tool for patients, although few applications have demonstrated reliability. …”
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    EHEALTH ON FRAILTY: FRAILSURVEY, A RELIABLE SMARTPHONE APPLICATION FOR SELF-ASSESSMENT OF FRAILTY
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