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  1. 21
    “…RESULTS: The aim of the present study was to synthetize a Jag-1 functionalized nanocarrier, which would promote an efficient interaction between the Jag-1 peptide and the Notch receptor. …”
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    Rational design of gold nanocarrier for the delivery of JAG-1 peptide
  2. 22
    “…Liver duct paucity is characteristic of children born with Alagille Syndrome (ALGS), a disease associated with JAGGED1 mutations. Here, we report that zebrafish embryos with compound homozygous mutations in two Notch ligand genes, jagged1b (jag1b) and jagged2b (jag2b) exhibit a complete loss of canonical Notch activity and duct cells within the liver and exocrine pancreas, whereas hepatocyte and acinar pancreas development is not affected. …”
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    Endoderm Jagged induces liver and pancreas duct lineage in zebrafish
  3. 23
    “…Our report broadens the spectrum of JAG1 gene mutations.…”
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    Alagille Syndrome: A Novel Mutation in JAG1 Gene
  4. 24
    “…However, one aspect of plasma DNA fragmentomics as to whether double-stranded plasma molecules might carry single-stranded ends, termed a jagged end in this study, remains underexplored. We have developed two approaches for investigating the presence of jagged ends in a plasma DNA pool. …”
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    Detection and characterization of jagged ends of double-stranded DNA in plasma
  5. 25
    “…The expression of JAG1 was not correlated with any other cognitive and symptomatic scales in all subjects. …”
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    Sex-specific involvement of the Notch–JAG pathway in social recognition
  6. 26
    “…This comprehensive guide to Bayesian methods in astronomy enables hands-on work by supplying complete R, JAGS, Python, and Stan code, to use directly or to adapt. …”
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    Bayesian models for astrophysical data: using R, JAGS, Python, and Stan
  7. 27
    “…The NOTCH ligands JAG1 and JAG2 have been correlated in vitro with multiple myeloma (MM) cell proliferation, drug resistance, self-renewal and a pathological crosstalk with the tumor microenvironment resulting in angiogenesis and osteoclastogenesis. …”
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    The Potential of JAG Ligands as Therapeutic Targets and Predictive Biomarkers in Multiple Myeloma
  8. 28
    “…We have mapped a Jagged/Serrate-binding site to specific residues within the 12th EGF domain of human and Drosophila Notch. …”
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    Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor
  9. 29
    “…The majority (90-94 %) of ALGS cases are caused by mutations in the JAG1 (JAGGED1) gene, and in a small percent of patients (∼1 %) mutations in the NOTCH2 gene have been described. …”
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    Spectrum of JAG1 gene mutations in Polish patients with Alagille syndrome
  10. 30
    “…One of the Notch ligands, Jagged1 (JAG1), is overexpressed in many cancer types, and plays an important role in several aspects of tumor biology. …”
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    The Notch Ligand Jagged1 as a Target for Anti-Tumor Therapy
  11. 31
    “…We used a conditional knockout approach to delete Jagged1 in cells of the renin lineage. Deletion of Jagged1 specifically within renin cells did not result in decreased renin production within the kidney. …”
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    Loss of Jagged1 in renin progenitors leads to focal kidney fibrosis
  12. 32
    “…Dysregulated Notch signaling has a critical role in the tumorigenesis. Jagged1, a Notch ligand, is overexpressed in various human cancers. …”
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    Silencing of Jagged1 inhibits cell growth and invasion in colorectal cancer
  13. 33
    “…We found that Jagged1 expression was reduced in the CA fields and that there was a gradual reduction of Jagged1 in the cerebrospinal fluid (CSF) with the progression of dementia. …”
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    Jagged1 Is Altered in Alzheimer's Disease and Regulates Spatial Memory Processing
  14. 34
    “…It has previously been shown that the transcription factor JAGGED LATERAL ORGANS (JLO), a member of the LATERAL ORGAN BOUNDARY DOMAIN (LBD) family, coordinates KNOX and PIN expression in the shoot and promotes root meristem growth. …”
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    The Arabidopsis JAGGED LATERAL ORGANS (JLO) gene sensitizes plants to auxin
  15. 35
    “…The decreased expression levels of JAG1 were restored in response to JAG1 overexpression, alongside increases in the protein expression levels of NICD, HES5 and HES1. …”
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    The antitumor function of arctigenin in human retinoblastoma cells is mediated by jagged-1
  16. 36
    “…Genetic testing revealed the novel variant c.802del in a single copy of the JAG1 gene. No variants in the NOTCH2 gene were detected. …”
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    Novel JAG1 Deletion Variant in Patient with Atypical Alagille Syndrome
  17. 37
    “…Most cases are associated with mutations in JAGGED1 (JAG1), which encodes a Notch ligand, although it is not clear how these contribute to disease development. …”
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    Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations
  18. 38
    “…Here, we studied the functional outcome of the dysregulation of Notch ligands, Jagged1 and Jagged2, occurring during disease progression, on the angiogenic potential of MM cells and BM stromal cells (BMSCs). …”
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    Jagged Ligands Enhance the Pro-Angiogenic Activity of Multiple Myeloma Cells
  19. 39
    “…In primary Leydig cells, Notch1 expression decreases with testicular development, while the expression of its ligand, Jagged1, remains relatively unchanged, suggesting that the roles of Jagged1 extend beyond Notch signaling. …”
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    Jagged1 intracellular domain modulates steroidogenesis in testicular Leydig cells
  20. 40
    “…Notch is a highly conserved cell to cell signaling pathway in evolution, and Jagged1 is an important ligand of Notch. Although some studies have found that Notch receptors and ligands including Jagged1 were highly expressed in osteosarcoma tissues and osteosarcoma cells, the role of Jagged1 in osteosarcoma progression and metastasis are still not clear. …”
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    The role of Notch ligand Jagged1 in osteosarcoma proliferation, metastasis, and recurrence
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