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  1. 561
    “…Our results proved that ATO had a significant dose-dependent and time-dependent inhibitory effect on the expressions of the Notch receptor (Notch1) and Notch ligand (Jag2). Data from the real-time PCR assay showed that the mRNA expression levels of the Jag2 gene and its downstream gene Hes1 were both significantly down-regulated after the myeloma cells were treated with ATO while the expression of the tumor suppressor gene PTEN was up-regulated. …”
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    Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway
  2. 562
    “…Here, we analyzed same-cell (cis) Notch-ligand interactions for Notch1, Dll1, and Jag1, and their dependence on Fringe protein expression in mammalian cells. …”
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    Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states
  3. 563
    “…Mutant neurons are unable to upregulate expression of Jag1 in response to cortical Wnt7, resulting in blunted activation of Notch signalling in NPC. …”
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    Feedback regulation of apical progenitor fate by immature neurons through Wnt7–Celsr3–Fzd3 signalling
  4. 564
    “…Here we investigated the expression of NOTCH3, its ligand JAG1, and mesenchymal stem cell markers CD146 and STRO-1 in the AP or in the primary cultures of SCAP isolated from AP. …”
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    NOTCH3 is expressed in human apical papilla and in subpopulations of stem cells isolated from the tissue
  5. 565
    “…HoxA3 induced upregulation of Jag1 ligand in endothelial cells, which led to cis-inhibition of the Notch pathway, rendering the HE nonresponsive to Notch signals. …”
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    Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation
  6. 566
    “…Endothelium-specific Shp2 deletion mice showed relieved collagen deposition along with disrupted radiation-induced Jag1 expression in the endothelium. Furthermore, endothelium-derived Jag1 activated the alternative activation of macrophages in vitro and in vivo by paracrine Notch signaling. …”
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    Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling
  7. 567
    “…Here, we analyzed the activation of NOTCH1/NOTCH2 (ICN1/ICN2) and the expression of JAGGED1 (JAG1) in 163 CLL patients and evaluated their impact on TTFT (Time To First Treatment) and OS (Overall Survival). …”
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    NOTCH1 Activation Negatively Impacts on Chronic Lymphocytic Leukemia Outcome and Is Not Correlated to the NOTCH1 and IGHV Mutational Status
  8. 568
    “…Annual training list frequency per trainee was 13 (10–17), 35.0 % short of Joint Advisory Group (JAG) standard (n = 20, P = 0.001, effect size –0.56). …”
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    Hospital compound-level endoscopy training quality performance: scoping the spectrum
  9. 569
    por Chen, Ying, Sun, Mei, Teng, Xu
    Publicado 2022
    “…The genes responsible for this disease are JAGGED1 (JAG1) and NOTCH2. Clinical data of this disease are limited in China. …”
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    Clinical and genetic analysis in Chinese children with Alagille syndrome
  10. 570
    “…Aβ injection significantly increased the expression of Notch1, Jag1, and Hes1 mRNA, while EA treatment downregulated the level of Notch1 and Hes1 mRNA in hippocampus, but not Jag1 mRNA. …”
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    Electroacupuncture Suppressed Neuronal Apoptosis and Improved Cognitive Impairment in the AD Model Rats Possibly via Downregulation of Notch Signaling Pathway
  11. 571
    “…The analysis of gremlin 1 (Grem1)-deficient forelimb buds showed that JAG1-expressing LMPs are protected from apoptosis by GREM1-mediated BMP antagonism. …”
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    Molecular signatures identify immature mesenchymal progenitors in early mouse limb buds that respond differentially to morphogen signaling
  12. 572
    “…We hypothesized that the promoters of FAP, CXCL12, IGFBP2, CTGF, JAG1, SNAI1, and SPARC genes, the expression of whose is increased in CAFs, could be used for transcriptional targeting. …”
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    Possibility for Transcriptional Targeting of Cancer-Associated Fibroblasts—Limitations and Opportunities
  13. 573
    “…We find differential expression of Notch ligands DLL1, JAG1, and JAG2 in myoepithelial cells, suggesting a paracrine interaction that may support oncogenic Notch signaling. …”
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    Single-cell RNA sequencing identifies a paracrine interaction that may drive oncogenic notch signaling in human adenoid cystic carcinoma
  14. 574
    “…Leptin positively correlated to OB-R, JAG1, VEGF, and marginally to IL-1R tI. Notch1 positively correlated to IL-1R tI. …”
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    NILCO biomarkers in breast cancer from Chinese patients
  15. 575
    “…INTRODUCTION: Alagille syndrome (ALGS) is an autosomal dominant disease characterized by a multisystem involvement including bile duct paucity and cholestasis, caused by JAG1 or NOTCH2 mutations in most of the cases. Jagged1-Notch2 interactions are known to be crucial for intrahepatic biliary tract development, but the Notch signaling pathway is also involved in the juxtacrine transmission of senescence and in the induction and modulation of the senescence-associated secretory phenotype (SASP). …”
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    Premature senescence of the liver in Alagille patients
  16. 576
    “…Forced expression of miR‐124 inhibited GC cell growth, migration and invasion, and induced cell cycle arrest. miR‐124 negatively regulated Notch1 signalling by targeting JAG1. miR‐124 levels were also shown to be inversely correlated with JAG1 expression in GC. …”
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    miR‐124 interacts with the Notch1 signalling pathway and has therapeutic potential against gastric cancer
  17. 577
    “…Over‐expression of miR‐634 inhibited the proliferation, migration, and invasion of gastric cancer cell lines, and the miR‐634 target gene was JAG1.…”
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    Expression of miR‐634 in gastric carcinoma and its effects on proliferation, migration, and invasion of gastric cancer cells
  18. 578
    “…As proof of principle, we applied DUCT to a mouse model for Alagille syndrome (Jag1(Ndr/Ndr) mice), characterized by intrahepatic bile duct paucity, that can spontaneously generate a biliary system in adulthood. …”
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    DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome
  19. 579
    “…Anterior segment anomalies are not currently associated with USP9X, yet our cases demonstrate ARA, congenital glaucoma, corneal neovascularization, and cataracts. The identification of JAG1 variants, linked with Alagille syndrome, in three separate families with a clinical diagnosis of ARA/ARS highlights the overlapping features and high variability of these two phenotypes. …”
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    Alternative Genetic Diagnoses in Axenfeld–Rieger Syndrome Spectrum
  20. 580
    “…To examine this, we prepared artificial antigen-presenting cells expressing either DLL1 or Jag1. Although both ligands were efficient in inducing Notch2 cleavage and activation in CD4(+) T or reporter cells, the presence of Lunatic Fringe in CD4(+) T cells inhibited Jag1 activation of Notch1 receptor. …”
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    Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition
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