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  1. 641
    “…The most frequently mutated DNA repairome genes were EXO1, ATR, POLQ, NEIL3, ERCC6, BRCA2, BRCA1, XPC, JAG1, RPA1, POLE, ATM, and LIG1 in African American men, and POLQ, NEIL3, POLB, BRCA2, EXO1, ERCC6, ATR, RBBP8, BRCA1, ATM, JAG1, XPC, and POLE in Caucasians. …”
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    Somatic mutations in the DNA repairome in prostate cancers in African Americans and Caucasians
  2. 642
    “…BACKGROUND: Alagille syndrome is an autosomal dominant disorder usually caused by pathogenic variants of the JAG1 gene. In the past, cholestasis was a condition sine qua non for diagnosis of the syndrome. …”
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    Peritoneal dialysis in an adult patient with tetralogy of Fallot diagnosed with incomplete Alagille syndrome
  3. 643
    “…OBSERVATIONS: A previously asymptomatic 29-year-old woman with a heterozygous pathogenic variant in the JAG1 gene was referred for an ophthalmic evaluation. …”
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    Ultra-widefield and anterior-segment optical coherence tomography in Alagille syndrome
  4. 644
    “…Moreover, Kaiso regulates several components of the Notch signaling pathway in intestinal cells, namely, Dll-1, Jagged-1 and Notch1. Notably, we found that in Kaiso (Tg) mice intestines, Notch1 and Dll-1 expression are significantly reduced while Jagged-1 expression is increased. …”
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    Kaiso differentially regulates components of the Notch signaling pathway in intestinal cells
  5. 645
    por Katoh, Masuko, Katoh, Masaru
    Publicado 2020
    “…NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta-like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. Canonical Notch signaling activates the transcription of BMI1 proto-oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context-dependent manner, while non-canonical Notch signaling activates NF-κB and Rac family small GTPase 1. …”
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    Precision medicine for human cancers with Notch signaling dysregulation (Review)
  6. 646
    “…Before sanger sequencing, variants of LRP5, NDP, FZD4, TSPAN12, ZNF408, KIF11, RCBTB1, JAG1, and CTNNA1 genes were verified by a series of bioinformatics tools and genotype–phenotype co‐segregation analysis. …”
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    Mutation spectrum in a cohort with familial exudative vitreoretinopathy
  7. 647
    “…The large variety of mutations to the JAG1 and NOTCH2 genes which lead to ALGS pose a unique challenge for developing targeted treatments. …”
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    Therapeutics Development for Alagille Syndrome
  8. 648
    “…Expression alterations of NOTCH2, NOTCH3, NOTCH4, JAG2, and HES1 were evaluated as independent and significant prognostic factors for uterine cancer patients.…”
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    Components of NOTCH Signaling for Uterine Cancer Patients' Prognosis
  9. 649
    por Strauss, Richard, 1864-1949
    Publicado 1991
    Tabla de Contenidos: “…Zueignung (Affection), op. 10 no. 1 ; Allerseelen (All souls), op. 10 no. 8 ; Befreit (Delivered), op. 39 no. 4 ; Cacilie (Cecilia), op. 27 no. 2 ; Wiegenlied (Cradle song), op. 41 no. 1 ; Standchen (Serenade), op. 17 no. 2 ; Ruhe, meine Seele (Rest, my soul), op. 27 no. 1 / Richard Strauss -- Svarta rosor (Black roses), op. 36 no. 1 ; Saf, saf, susa (Sigh, sedges, sigh), op. 36 no. 4 ; Im Feld ein Madchen singt (A maiden yonder sings), op. 50 no. 3 ; Varen flyktar hastigt (Spring is flying), op. 13 no. 4 ; Den forsta kryssen (The first kiss), op. 37 no. 1 ; Flickan kom ifran sin alsklings mote (The tryst), op. 37 no. 5 ; Pa verandan vid havet (On a balcony by the sea), op. 38 no. 2 ; Se'n har jag ej fragat mera (And I questioned then no further), op. 17 no. 1 ; Illalle (To evening), op. 17 no. 6 ; Var det en drom? …”
    CD Audiom
    Songs
  10. 650
    “…We report a now 6-year-old African-American male with both Alagille syndrome and pediatric sarcoidosis. With a prior JAG1 mutation positive diagnosis of Alagille syndrome, he presented to the hospital with a subacute, predominantly respiratory febrile condition, eventually diagnosed as sarcoidosis. …”
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    Sarcoidosis in a young child with Alagille syndrome: a case report
  11. 651
    “…Reduced representation bisulfite sequencing (RRBS) indicated significant hypomethylation in myoblasts, myotubes, and skeletal muscle vs. many nonmuscle samples at intragenic or intergenic regions of the following Notch receptor or ligand genes: NOTCH1, NOTCH2, JAG2, and DLL1. An enzymatic assay of sites in or near these genes revealed unusually high enrichment of 5-hydroxymethylcytosine (up to 81%) in skeletal muscle, heart, and cerebellum. …”
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    Notch signaling genes: Myogenic DNA hypomethylation and 5-hydroxymethylcytosine
  12. 652
    “…Both analogs were potent inhibitors of binding to and activation of Notch1 by Notch ligands Dll1 and Dll4, but not by Jag1. Mutagenesis and modeling studies suggest that incorporation of the analogs into EGF8 of Notch1 markedly reduces the ability of Delta ligands to bind and activate Notch1.…”
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    Inhibition of Delta-induced Notch signaling using fucose analogs
  13. 653
    “…Instead, the transitional zone for lens differentiation was shifted anteriorly as a result of reduced Jag1-Notch signaling. We also showed that Etv proteins suppresses mTOR activity by promoting Tsc2 expression, which is necessary for the nuclei clearance in mature lens. …”
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    Etv transcription factors functionally diverge from their upstream FGF signaling in lens development
  14. 654
    “…The Ca(2+) influx was the highest in the untreated control group. qPCR results showed that as the concentration of Sa12b increased, the relative expression of Oct4, Nanog, Jag1, Notch1, collagen II, aggrecan, and SOX-9 increased, while that of ASIC1, ASIC2, ASIC3, and ASIC4 decreased. …”
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    Sa12b Improves Biological Activity of Human Degenerative Nucleus Pulposus Mesenchymal Stem Cells in a Severe Acid Environment by Inhibiting Acid-Sensitive Ion Channels
  15. 655
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    A deep learning approach for automatic identification of ancient agricultural water harvesting systems
  16. 656
    “…Both the infant and the mother were diagnosed with Alagille syndrome, both having the same heterozygous JAG1 gene (NM_000214.2) variant (c.1890_1893del, p.Ile630Metfs*112). …”
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    A neonatal case of vascular ring with Alagille syndrome
  17. 657
    “…These genes were connected to known pathways of tumorigenesis revealed by the v-maf (musculoaponeurotic fibrosarcoma) oncogene homolog (MAF), notch receptor ligand, jagged 1 (JAG1), and the alanyl aminopeptidase (ANPEP/CD13) genes. …”
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    Prostate cancer gene expression signature of patients with high body mass index
  18. 658
    “…Mechanistically, endothelial ephrinB2 and Jagged1 mediate these effects by suppressing cell-cycle entry downstream of mitogens and inducing stemness genes to jointly inhibit differentiation. …”
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    Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells
  19. 659
    “…Shoot apices of the transgenic lines showed elevated expression of JAGGED (JAG) and the auxin transporter PIN1. In a PIN1-GFP fusion reporter/SUS-RNAi hybrid, PIN1-GFP patterns were altered in developing leaves (as compared to control plants), indicating that SlSUS suppression alters auxin signaling. …”
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    Suppression of sucrose synthase affects auxin signaling and leaf morphology in tomato
  20. 660
    “…MRK16 markedly inhibited the growth of AD10 cells mixed with IL2 AD10 cells under conditions (0.3–1 jag/body) where it showed only marginal effects on the growth of AD10 tumors. …”
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    Combination Therapy with Antibody and Interleukin–2 Gene Transfer against Multidrug–resistant Cancer Cells
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