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681por Grieselhuber, Nicole R., Klco, Jeffery M., Verdoni, Angela M., Lamprecht, Tamara, Sarkaria, Shawn M., Wartman, Lukas D., Ley, Timothy J.“…Acute promyelocytic leukemia (APL) is initiated by the PML-RARA fusion oncogene and has a characteristic expression profile that includes high levels of the Notch ligand JAG1. In this study, we used a series of bioinformatic, in vitro, and in vivo assays to assess the role of Notch signaling in human APL samples, and in a PML-RARA knockin mouse model of APL (Ctsg-PML-RARA). …”
Publicado 2013
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682por Hoare, Matthew, Ito, Yoko, Kang, Tae-Won, Weekes, Michael P., Matheson, Nicholas J., Patten, Daniel A., Shetty, Shishir, Parry, Aled J., Menon, Suraj, Salama, Rafik, Antrobus, Robin, Tomimatsu, Kosuke, Howat, William, Lehner, Paul J., Zender, Lars, Narita, Masashi“…NOTCH1 and NOTCH1-driven TGF-β contribute to ‘lateral induction of senescence’ through a juxtacrine NOTCH-JAG1 pathway. In addition, NOTCH1 inhibition during senescence facilitates upregulation of pro-inflammatory cytokines, promoting lymphocyte recruitment and senescence surveillance in vivo. …”
Publicado 2016
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683“…Moreover, dendrites in cultured MCs were shortened by Jag1-expressing cells. Finally, blocking the activity of Notch ligands in OSNs led to an increase in dendritic complexity as well as a decrease in NICD1 signals in MCs. …”
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684por Ciampalini, Andrea, Bardi, Federica, Bianchini, Silvia, Frodella, William, Del Ventisette, Chiara, Moretti, Sandro, Casagli, NicolaEnlace del recurso
Publicado 2014
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685por Xu, Lu, Zhou, Jianjun, Liu, Jingyu, Liu, Yong, Wang, Lei, Jiang, Ruiwei, Diao, Zhenyu, Yan, Guijun, Pèault, Bruno, Sun, Haixiang, Ding, Lijun“…Microarray, qRT-PCR, and Western blot analysis showed that UCA-PSCs had the highest expression of the Notch ligand Jagged1 (JAG1), which is crucial for blood vessel maturation. …”
Publicado 2017
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686por Wilschut, Liesbeth I., Heesterbeek, Johan A.P., Begon, Mike, de Jong, Steven M., Ageyev, Vladimir, Laudisoit, Anne, Addink, Elisabeth A.Enlace del recurso
Publicado 2018
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687por Jam, Faidruz Azura, Kadota, Yosuke, Mendsaikhan, Anarmaa, Tooyama, Ikuo, Mori, Masaki“…Thus, the JAGs might organize the juvenile property of young animals and analysis of JAGs may provide scientific and therapeutic approaches toward treating the genetic diseases.…”
Publicado 2018
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688“…We analyzed tissue from 195 HNSCCs and tissue from 30 normal patients for mRNA expression of NOTCH1, NOTCH3, HES1, HEY1, and JAG1 using quantitative real-time PCR. Association of expression results and clinical orpathological factors was examined with multivariate Cox regression. …”
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689“…Alagille syndrome (ALGS) is an autosomal dominant disorder, with multisystem involvement, which usually occurs due to Notch signaling pathway defects, mostly due to JAG1 mutation (ALGS type 1), but rarely due to neurogenic locus notch homolog protein (NOTCH2) mutation (ALGS type 2). …”
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690“…Furthermore, expression of TCF-4 J-responsive target genes (SPP1, AXIN2, MMP7, ASPH, JAG1, CD24, ANXA1, and CAMK2N1) was reduced by CC-122 and not by LEN or control. …”
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692por Choi, Jinwook, Jang, Yu Jin, Dabrowska, Catherine, Iich, Elhadi, Evans, Kelly V., Hall, Helen, Janes, Sam M., Simons, Benjamin D., Koo, Bon-Kyoung, Kim, Jonghwan, Lee, Joo-Hyeon“…Upon damage, IL-1β signalling-dependent modulation of Jag1/2 expression in ciliated cells results in the inhibition of Notch signalling in secretory cells, which drives reprogramming and acquisition of differentiation plasticity. …”
Publicado 2021
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694por Li, Jing, Qu, Weixing, Jiang, Yazhou, Sun, Yi, Cheng, Yongyi, Zou, Tiejun, Du, Shuangkuan“…Moreover, bioinformatics and luciferase reporter gene assays confirmed that miR-489 targeted the mRNA 3′-untranslated region (3′-UTR) region of Jagged1 (JAG1), a Notch ligand. In conclusion, miR-489 suppressed proliferation and invasion of human bladder cancer cells.…”
Publicado 2016
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695por Saito, Junichi, Kojima, Tomoyuki, Tanifuji, Shota, Kato, Yuko, Oka, Sayuki, Ichikawa, Yasuhiro, Miyagi, Etsuko, Tachibana, Tsuyoshi, Asou, Toshihide, Yokoyama, Utako“…Cardiac neural crest-related genes such as JAG1 were highly expressed in the tunica media and IT of the closing DA samples compared to the patent DA sample. …”
Publicado 2021
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696por Ge, Yong, Zhang, Wen-Bin, Liu, Haiyan, Ruktanonchai, Corrine W, Hu, Maogui, Wu, Xilin, Song, Yongze, Ruktanonchai, Nick W, Yan, Wei, Cleary, Eimear, Feng, Luzhao, Li, Zhongjie, Yang, Weizhong, Liu, Mengxiao, Tatem, Andrew J, Wang, Jin-Feng, Lai, ShengjieEnlace del recurso
Publicado 2022
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697por Zhou, Cong, Zhang, Yuanyuan, Bassey, Anthony, Huang, Jie, Zou, Yafang, Ye, Keping“…Furthermore, L. monocytogenes decreased the relative expression of Notch pathway-related genes (Jag1, Dll4, Notch1, and Hes1) while upregulating the relative expression of Math1 gene in mice and intestinal organoids. …”
Publicado 2022
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698por Yuan, Shi-Min“…Alagille syndrome, caused by mutations in the gene encoding Jagged1 (JAG1), a ligand in the Notch signaling pathway, is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, face and skeleton. …”
Publicado 2022
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699por Orchard, Kayleigh J. A., Akbar, Moeed, Crowe, Lindsay A. N., Cole, John, Millar, Neal L., Raleigh, Stuart M.“…For H3K4, 24 genomic loci were found to be significantly more trimethylated in RCT compared to control (p < 0.05), implicating genes such as DKK2, JAG2, and SMOC2 in RCT. For H3K27, 31 loci were shown to be more trimethylated (p < 0.05) in RCT compared to control, inferring a role for EPHA3, ROCK1, and DEFβ115. …”
Publicado 2023
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700por Kim, T-M, Ha, S-A, Kim, H K, Yoo, J, Kim, S, Yim, S-H, Jung, S-H, Kim, D-W, Chung, Y-J, Kim, J W“…Upregulation of EGF and JAG1 oncogenes as well as genes encoding ATP-dependent drug efflux pump proteins such as ABCB1 was also observed in the resistant cells, which may confer alternative survival benefits. …”
Publicado 2011
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