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Mostrando 701 - 720 Resultados de 1,374 Para Buscar '"JAG"', tiempo de consulta: 0.18s Limitar resultados
  1. 701
    “…These rare or novel protein altering mutations cluster predominantly in genes (NOTCH1, ARHGAP31, MAML1, SMARCA4, JARID2, JAG1) along the Notch signaling cascade. This is in line with a significant enrichment (Wilcoxon, p< 0.05) of variants with a higher pathogenicity in the Notch signaling pathway in patients compared to controls. …”
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    Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital Heart Disease
  2. 702
    “…Here we expanded mouse muscle stem cells and human myoblasts with Notch ligands, DLL1, DLL4, and JAG1 to activate Notch signaling in vitro and to investigate whether these cells could retain their engraftment efficiency. …”
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    Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity
  3. 703
    “…In contrast, fibroblast growth factor receptors (FGFRs) recruit Fibroblast Growth Factor Receptor Substrate 2 (Frs2) and Rous sarcoma oncogene (Src) Homology Phosphatase 2 (Shp2) to activate Mitogen-Activated Protein Kinase (MAPK) signaling, which induces the Notch ligand Jagged 1 (Jag1) and promotes cell differentiation. …”
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    Lens differentiation is controlled by the balance between PDGF and FGF signaling
  4. 704
    por Ma, Ning-Xin, Yin, Jiu-Chao, Chen, Gong
    Publicado 2019
    “…Our gene network analyses reveal many well-connected hub genes such as repulsive guidance molecule A (RGMA), neuronatin (NNAT), neurogenin 2 (NEUROG2), NPTX2, MOXD1, JAG1, and GAP43, which may coordinate the chemical reprogramming process. …”
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    Transcriptome Analysis of Small Molecule–Mediated Astrocyte-to-Neuron Reprogramming
  5. 705
    “…Among others, the major signaling pathways include the phosphoinositide 3 kinase (PI3K) pathway/the antiapoptotic kinase (AKT) pathway/the endothelial nitric oxide synthase (eNOS) pathway, the Erk1, the delta-like ligand (DII), the jagged (Jag)/NOTCH pathway, and the midkine regulatory cytokine signaling pathways.…”
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    Arteriogenesis of the Spinal Cord—The Network Challenge
  6. 706
    por Qiao, Mengling, Huang, Bo
    Publicado 2022
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    Assessment of community vulnerability during the COVID-19 pandemic: Hong Kong as a case study
  7. 707
    “…Upregulated genes at E14.5 included Fgf20, as well as several Notch pathway genes (Lfng, Hes1, and Jag1). CONCLUSIONS: This study characterizes Prdm16 expression during cochlear development and establishes its requirement for KO development.…”
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    PRDM16 expression and function in mammalian cochlear development
  8. 708
    “…DC. , on Notch signaling and upstream molecules (Notch1 and Notch2 receptors, JAG1, mTOR, PI3K, and YAP), and downstream molecules (Snail) in HuCCT-1 (CCA cell line) and OUMS-36T-1 (normal fibroblast cell line). …”
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    Atractylodin and β-eudesmol from Atractylodes lancea (Thunb.) DC. Inhibit Cholangiocarcinoma Cell Proliferation by Downregulating the Notch Signaling Pathway
  9. 709
    “…We identified genomic structural variations that lead to potential enhancer hijacking and gene coamplification, including A2M, JAG2, and FLRT1. Together, our results imply three-dimensional genome alterations may play a critical role in the pHGG epigenetic landscape and contribute to tumorigenesis.…”
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    Epigenomic landscape and 3D genome structure in pediatric high-grade glioma
  10. 710
    “…At the early stage of injury, infiltrating MoMFs activated the Jagged1/notch homolog protein 2 (JAG1/NOTCH2) axis to induce cell death–resistant SRY-box transcription factor 9(+) (SOX9(+)) hepatocytes near the necrotic lesions, which acted as a barrier from further injury. …”
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    Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models
  11. 711
    por Uhl, Johannes H., Leyk, Stefan
    Publicado 2023
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    Spatially explicit accuracy assessment of deep learning-based, fine-resolution built-up land data in the United States
  12. 712
    “…CNVs in a single TOF case occurred at six loci, two that encode known (NOTCH1, JAG1) disease genes. Our data predicts that at least 10% (4.5–15.5, 95% CI) of sporadic, non-syndromic TOF reflects de novo CNVs and implicates mutations within these loci as etiologic in other cases of TOF.…”
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    De Novo Copy Number Variants Identify New Genes and Loci in Isolated, Sporadic Tetralogy of Fallot
  13. 713
    “…This set includes novel prostate TIC growth factors (NRP1, GDF1, JAG1), proteins implicated in cell adhesion and cytoskeletal maintenance, transcriptional regulators (MYCBP, MYBL1, ID1, ID3, FOS, ELF3, ELF4, KLF2, KLF5) and factors involved in protein biosynthesis and metabolism. …”
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    Genomic profiling of tumor initiating prostatospheres
  14. 714
    “…Up-regulation of this gene, as well as JAG1 (and down-regulation of JAM3), was confirmed using real time PCR both with transfected HEK293 cells and human peripheral blood leukocytes. …”
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    Downstream Gene Activation of the Receptor ALX by the Agonist Annexin A1
  15. 715
    “…Among them, a Notch ligand, JAG1 was regulated directly by Smad1/5, transactivating Notch signaling in the neighboring cells. …”
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    ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif
  16. 716
    “…Expression levels of Notch signaling molecules such as NICD, DLLs, JAG1, HES1 and HES5 were increased in the NESs. …”
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    Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells
  17. 717
    “…RESULTS: Our study suggests evidence of association (P = 0.0004-0.0067) for 8 independent loci (nominal significance P < 0.05), which are located within or near the following genes involved in immune signaling: JAG1, DYNLRB2, EBF1, TMEFF2, CCL17, HAUS6, PENK and TXNDC4. …”
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    A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians
  18. 718
    “…BMP4 activation of a MAD-homolog (Smad)-dependent reporter in undifferentiated ES cells was attenuated by co-stimulation with RA and co-culture with PA6 cells. The Notch ligand Jag1 was expressed in PA6 cells and inhibition of Notch signalling blocked the differentiation inducing activity of PA6 cells. …”
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    Efficient Differentiation of Embryonic Stem Cells into Mesodermal Precursors by BMP, Retinoic Acid and Notch Signalling
  19. 719
    “…Genomic responses were also assessed with domain-specific effects emerging, so the N-terminal region is required for AnxA1 induction of JAG1 and JAM3, whereas it is dispensable for modulation of SGPP2. …”
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    Annexin A1 Interaction with the FPR2/ALX Receptor: IDENTIFICATION OF DISTINCT DOMAINS AND DOWNSTREAM ASSOCIATED SIGNALING
  20. 720
    “…We cloned the full length 3′UTR of Amex-Jag1, and our in vitro assays demonstrated that its single miR-21 target recognition site is functional and essential for the response of the Jagged1 gene to miR-21 levels. …”
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    Microarray Analysis of microRNA Expression during Axolotl Limb Regeneration
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