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781por Kwon, Yu-Jin, Kim, Jung Oh, Park, Jae-Min, Choi, Ja-Eun, Park, Da-Hyun, Song, Youhyun, Kim, Seong-Jin, Lee, Ji-Won, Hong, Kyung-Won“…In participants whose sodium intake was greater than 2 g/day, chromosome 6 open reading frame 10 (C6orf10)-human leukocyte antigen (HLA)-DQB1 rs6913309, ring finger protein (RNF)213 rs112735431, glycosylphosphatidylinositol anchored molecule-like (GML)- cytochrome P450 family 11 subfamily B member 1(CYP11B1) rs3819496, myosin light chain 2 (MYL2)-cut like homeobox 2 (CUX2) rs12229654, and jagged1 (JAG1) rs1887320 were significantly associated with hypertension. …”
Publicado 2020
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782por Sinha, Sanjiv K., Padalia, Hitendra, Dasgupta, Anindita, Verrelst, Jochem, Rivera, Juan PabloEnlace del recurso
Publicado 2020
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783“…Results: By comparing the differentially lncRNA genes between IDH mutant and IDH wild-type glioma samples, a four-lncRNA (JAG1, PVT1, H19, and HAR1A) signature was identified in IDH mutant glioma patients. …”
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784por Ling, Xiangtian, Ma, Xinqi, Kuang, Xielan, Zou, Yuxiu, Zhang, Han, Tang, Han, Du, Han, Zhu, Binbin, Huang, Hao, Xia, Qing, Chen, Minghao, Mao, Danyi, Chen, Dongli, Shen, Huangxuan, Yan, Jianhua“…Results from QRT-PCR assays revealed that following treatment with lidocaine, Notch1, Notch2, Hes1, Csl and Dll4 all showed higher levels of expression, while no changes were observed in Mmal1, Hey1, Dll1 and Jag1. CONCLUSION: This work provides the first description of the effects of lidocaine upon the regeneration of muscles and maintenance of satellite cells at the cellular and molecular levels. …”
Publicado 2021
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786por Jiang, Ming, Tang, Tianxiang, Liang, Xinyue, Li, Juchen, Qiu, Yue, Liu, Shiwen, Bian, Shan, Xie, Yunli, Fang, Fang, Cang, Jing“…Reactivation of Notch by Jag1 and NICD overexpression rescued the defects in INM. …”
Publicado 2021
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787“…Concomitantly, expression of several genes implicated in angiogenesis and fibrosis, namely TGFß2, VEGFR2, ALK1, JAG1, TIMP2, SMAD5, SMAD6 and SMAD7, was slightly upregulated. …”
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788por Shi, Xiaoguang, Ren, Shuanglai, Zhang, Bingying, Guo, Shanshan, He, Wenxin, Yuan, Chengmin, Yang, Xiaofan, Ig-lzevbekhai, Kevin, Sun, Tao, Wang, Qinwen, Cui, Jianqi“…In the end, totaly 656 differentially expressed genes between HT22 and Purα-KO HT22 cells have been found, which include 7 Alzheimer’s disease (AD)-related genes and 5 Aβ clearance related genes. 47 genes were regulated by Purα directly, the evidence based on CHIP-seq, which include Insr, Mapt, Vldlr, Jag1, etc. Our study provides the important informations of Purα in neuro-development. …”
Publicado 2021
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789por da Palma, Mariana Matioli, Igelman, Austin D., Ku, Cristy, Burr, Amanda, You, Jia Yue, Place, Emily M., Wang, Nan-Kai, Oh, Jin Kyun, Branham, Kari E., Zhang, Xinxin, Ahn, Jeeyun, Gorin, Michael B., Lam, Byron L., Ronquillo, Cecinio C., Bernstein, Paul S., Nagiel, Aaron, Huckfeldt, Rachel, Cabrera, Michelle T., Kelly, John P., Bakall, Benjamin, Iannaccone, Alessandro, Hufnagel, Robert B., Zein, Wadih M., Koenekoop, Robert K., Birch, David G., Yang, Paul, Fahim, Abigail T., Pennesi, Mark E.“…Abnormalities of the optic disc were found in 52%, and peripheral retinal abnormalities were the most frequent ocular finding in this series, found in 96% of all patients. Fifteen JAG1 mutations were identified in 16 individuals; of those, 6 were novel. …”
Publicado 2021
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790por Xue, Ke, Zheng, Huilin, Qian, Xiaowen, Chen, Zheng, Gu, Yangjun, Hu, Zhenhua, Zhang, Lei, Wan, Jian“…Our analysis identified six genes as risk factors for predicting metastatic status by LASSO regression, including zinc finger BED-Type Containing 2 (ZBED2), S100 calcium-binding protein A2 (S100A2), Jagged canonical Notch ligand 1 (JAG1), laminin subunit gamma 2 (LAMC2), transglutaminase 2 (TGM2), and the transcription factor hepatic leukemia factor (HLF). …”
Publicado 2021
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791por Cwiek, Aleksandra, Suzuki, Masako, deRonde, Kimberly, Conaway, Mark, Bennett, Kevin M., El Dahr, Samir, Reidy, Kimberly J., Charlton, Jennifer R.“…Kidneys from the preterm mice also had altered nephron progenitor subpopulations, early Six2 depletion, and altered Jag1 expression in the nephrogenic zone, consistent with premature differentiation of nephron progenitor cells. …”
Publicado 2021
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792por Jin, Junling, Verbeurgt, Jeffrey, De Sloover, Lars, Stal, Cornelis, Deruyter, Greet, Montreuil, Anne-Lise, Vos, Sander, De Maeyer, Philippe, De Wulf, AlainEnlace del recurso
Publicado 2021
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793“…A pathogenic variant of the JAG1 gene (c.1326G > A, p.Trp442X) was detected through genetic testing. …”
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794por Zhou, Guannan, Gu, Yuanyuan, Zhou, Fangyue, Zhang, Hongdao, Zhang, Menglei, Zhang, Ganrong, Wu, Ligang, Hua, Keqin, Ding, Jingxin“…Adipocyte-derived extracellular vesicles inhibited viability and promoted apoptosis in CCs via targeting JAG1. Furthermore, extracellular vesicles derived from mature adipocyte disrupted the ovary ovulation and impaired the hormone levels. …”
Publicado 2022
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795por Zhao, Fei, Zhang, Sujin, Zhang, Degang, Peng, Zhiyan, Zeng, Hongyun, Zhao, Zhifang, Jin, Wei, Shen, Wenyu, Liu, WeiEnlace del recurso
Publicado 2022
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796por Bae, Yangjin, Zeng, Huan‐Chang, Chen, Yi‐Ting, Ketkar, Shamika, Munivez, Elda, Yu, Zhiyin, Gannon, Francis H., Lee, Brendan H.“…We found that miR‐34c regulates the transcription of several genes in Notch signaling (NOTCH1, JAG1, and HEY2) and in p53‐mediated cell cycle and apoptosis (CCNE2, E2F5, E2F2, and HDAC1). …”
Publicado 2022
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798por Radetti, Giorgio, Rigon, Franco, Salvatoni, Alessandro, Campi, Irene, De Filippis, Tiziana, Cirello, Valentina, Longhi, Silvia, Guizzardi, Fabiana, Bonomi, Marco, Persani, Luca“…These latter were performed by Sanger sequence or targeted next-generation sequencing technique including a panel of candidate genes involved in thyroid hormone actions and congenital hypothyroidism (CH): THRA, THRB, DIO1, DIO2, SLC16A2, SECISBP2, DUOX2, DUOXA2, FOXE1, GLIS3, IYD, JAG1, NKX2-1, NKX2- 5, PAX8, SLC26A4, SLC5A5, TG, TPO, TSHR. …”
Publicado 2022
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799“…Analysis of crypt organoids revealed that through integrins α(v)β(3)/α(v)β(5), CCN1 induces NF-κB-dependent Jag1 expression to regulate Notch activation for differentiation and promotes Src-mediated YAP activation and Dkk1 expression to control Wnt signaling for proliferation. …”
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