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801por Zhong, Leiyang, Zhou, Ying, Gao, Song, Yu, Zhaoyang, Ma, Zhifeng, Li, Xiaoming, Yue, Yang, Xia, JizheEnlace del recurso
Publicado 2022
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803por Huang, Xiao, Wang, Siqin, Zhang, Mengxi, Hu, Tao, Hohl, Alexander, She, Bing, Gong, Xi, Li, Jianxin, Liu, Xiao, Gruebner, Oliver, Liu, Regina, Li, Xiao, Liu, Zhewei, Ye, Xinyue, Li, ZhenlongEnlace del recurso
Publicado 2022
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805por Han, Limin, Wu, Jingyun, Wang, Mimi, Zhang, Zhentao, Hua, Dian, Lei, Shufeng, Mo, Xingbo“…We found 300 RNAm-SNPs significantly associated with BMD, including 249 m(6)A-, 28 m(1)A-, 3 m(5)C-, 7 m(7)G- and 13 A-to-I-related SNPs. m(6)A-SNPs in OP susceptibility genes, such as WNT4, WLS, SPTBN1, SEM1, FUBP3, LRP5 and JAG1, were identified and functional enrichment for m(6)A-SNPs in the eBMD GWAS dataset was detected. eQTL signals were found for nearly half of the identified RNAm-SNPs, and the affected gene expression was associated with BMD and fracture. …”
Publicado 2022
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806por Wang, Siqin, Huang, Xiao, Hu, Tao, She, Bing, Zhang, Mengxi, Wang, Ruomei, Gruebner, Oliver, Imran, Muhammad, Corcoran, Jonathan, Liu, Yan, Bao, ShumingEnlace del recurso
Publicado 2023
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807por Liu, Hongyu, Khan, Ibrar Muhammad, Liu, Yong, Khan, Nazir Muhammad, Ji, Kaiyuan, Yin, Huiqun, Wang, Wenliang, Zhou, Xinqi, Zhang, Yunhai“…Pathway analyses for miRNA-linked genes were performed and identified JAG2, BCL6, CFAP157, PHC2, TYRO3, SEPTIN6, and BSP3; these genes were involved in biological pathways such as TNF signaling, T cell receptor, PI3KAkt signaling, and functions affecting testes development and spermatogenesis. …”
Publicado 2022
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808“…Genetic testing of 12 children with ALGS revealed JAG1 gene mutations in 7 cases and NOTCH2 gene mutations in 2 cases. …”
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809por Ning, Huan, Li, Zhenlong, Qiao, Shan, Zeng, Chengbo, Zhang, Jiajia, Olatosi, Bankole, Li, XiaomingEnlace del recurso
Publicado 2023
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810por Wang, Shengran, Greenbaum, Jonathan, Qiu, Chuan, Gong, Yun, Wang, Zun, Lin, Xu, Liu, Yong, He, Pei, Meng, Xianghe, Zhang, Qiang, Shen, Hui, Vemulapalli, Krishna Chandra, Sanchez, Fernando L., Schiller, Martin R., Xiao, Hongmei, Deng, Hongwen“…RESULTS: We constructed immune cell and OBC communication networks and further identified L-R genes, such as JAG1 and NOTCH1/2, with ossification related functions. …”
Publicado 2023
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811por Cuaycal, Alexandra E., Teixeira, Leandro Dias, Lorca, Graciela L., Gonzalez, Claudio F.“…RNAseq-based analysis showed that BMDCs stimulated with L. johnsonii N6.2 total lipids upregulate maturation-mig related genes Cd86, Cd40, Ccr7, Icam1 along with immunoregulatory genes including Itgb8, Nfkbiz, Jag1, Adora2a, IL2ra, Arg1, and Cd274. Quantitative reverse transcription (qRT)-PCR analysis indicated that PLs are the bioactive lipids triggering the BMDCs response. …”
Publicado 2023
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812por Liang, Bin, Yang, Fang, Huang, Hailong, Liu, Zhaozhen, Ji, Qingqiang, Wang, Yan, Wu, Xiaoqing, Lin, Yuan, Xie, Lanting, Zhao, Wantong, Cao, Hua, Xu, Liangpu, Lin, Na“…Two neonates who underwent WES were diagnosed with CHD7-associated Charge syndrome and JAG1-associated Alagille syndrome, respectively. …”
Publicado 2023
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813“…Remarkably, leptin up-regulated Notch1-4/JAG1/Dll-4, Notch target genes: Hey2 and survivin, together with IL-1 and VEGF/VEGFR-2. …”
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814por Wilschut, L.I., Addink, E.A., Heesterbeek, J.A.P., Dubyanskiy, V.M., Davis, S.A., Laudisoit, A., M.Begon, Burdelov, L.A., Atshabar, B.B., de Jong, S.M.Enlace del recurso
Publicado 2013
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815por De Salvo, Maria, Raimondi, Lavinia, Vella, Serena, Adesso, Laura, Ciarapica, Roberta, Verginelli, Federica, Pannuti, Antonio, Citti, Arianna, Boldrini, Renata, Milano, Giuseppe M., Cacchione, Antonella, Ferrari, Andrea, Collini, Paola, Rosolen, Angelo, Bisogno, Gianni, Alaggio, Rita, Inserra, Alessandro, Locatelli, Mattia, Stifani, Stefano, Screpanti, Isabella, Miele, Lucio, Locatelli, Franco, Rota, Rossella“…Interestingly, knockdown of Notch canonical ligands JAG1 or DLL1 in RMS cell lines decreases Notch3 activity and reduces cell proliferation. …”
Publicado 2014
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816por Asnaghi, Laura, Lin, Michael H., Lim, Kah Suan, Lim, Kah Jing, Tripathy, Arushi, Wendeborn, Murilo, Merbs, Shannath L., Handa, James T., Sodhi, Akrit, Bar, Eli E., Eberhart, Charles G.“…We found that Notch pathway components, including Jag1-2 ligands, Hes1-Hey1 targets and the intracellular domain of Notch1, were increased in hypoxia, as well as the phosphorylation levels of Erk1-2 and Akt. …”
Publicado 2014
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817por Morrison, Alanna C., Bis, Joshua C., Hwang, Shih-Jen, Ehret, Georg B., Lumley, Thomas, Rice, Kenneth, Muzny, Donna, Gibbs, Richard A., Boerwinkle, Eric, Psaty, Bruce M., Chakravarti, Aravinda, Levy, Daniel“…Six genes – ATP2B1, CACNB2, CYP17A1, JAG1, PLEKHA7, and SH2B3 – were evaluated for sequence variation with large effects on systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and mean arterial pressure (MAP). …”
Publicado 2014
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818“…HC development and maintenance also depend on the expression of other genes (Sox2, Eya1, Gata3, Pax2) and several genes have been identified that can induce HCs when misexpressed (Jag1) or knocked out (Lmo4). In the ear Atoh1 is not only expressed in HCs but also in some supporting cells and neurons that do not differentiate into HCs. …”
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819por Zayats, Tetyana, Athanasiu, Lavinia, Sonderby, Ida, Djurovic, Srdjan, Westlye, Lars T., Tamnes, Christian K., Fladby, Tormod, Aase, Heidi, Zeiner, Pål, Reichborn-Kjennerud, Ted, Knappskog, Per M., Knudsen, Gun Peggy, Andreassen, Ole A., Johansson, Stefan, Haavik, Jan“…Statistical analyses were divided into several steps: (1) genome-wide association in the form of logistic regression in PLINK and follow-up pathway analyses performed in DAPPLE and INRICH softwares, (2) SNP-heritability calculated using genome-wide complex trait analysis (GCTA) tool, (3) gene-based association tests carried out in JAG software, and (4) evaluation of previously reported genome-wide signals and candidate genes of ADHD. …”
Publicado 2015
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820por Zheng, X, Demirci, F Y, Barmada, M M, Richardson, G A, Lopez, O L, Sweet, R A, Kamboh, M I, Feingold, E“…We also observed suggestive associations of duplications with AD+P in the SET (P=1.95E−06), JAG2 (P=5.01E−07) and ZFPM1 (P=2.13E−07) genes and marginal association of a deletion in CNTLN (P=8.87E−04). …”
Publicado 2015
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