“…The Notch pathway arises from the interaction of one of the Notch receptors (Notch1–4) with different types of ligands; in particular, the Notch pathway can be activated canonically (through the ligands Jagged1, Jagged2, DLL1, DLL3 or DLL4) or non-canonically (through various molecules shared by other pathways). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This study assessed the effects of simple stimuli (i.e., jagged edges shape, disk, star, spiral, eye-like shape, and head character) on the emotional responses of different groups of humans. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Methods: We examined expression of Notch signaling genes in FACS-sorted ALDH1(+) putative ovarian CSCs and expression of ALDH1 and Notch signaling genes in 86 ovarian epithelial tumors and various ovarian cancer cell lines by real-time RT-PCR, including Notch receptors (Notch1-4), Notch ligands (Jagged1 and Jagged2), and the downstream molecule, Hes1. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In parallel, CD45(−) bone marrow stromal cells expressed high levels of mRNA IL-7, Notch ligands (Jagged-1 and Delta-like 4), and transcription factors (Hes-1, Hey-1, Hey-2 and Hey-L). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Treatment with 50 nM Lir for 2 hours before H/R significantly increased the expression levels of Notch1, Jagged1, and Bcl-2 compared with the CT levels. Bax was downregulated, which indicated that Lir activated Notch signaling and inhibited apoptosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results suggest that ELA activates VEFG/VEGFR2 and Jagged1/Notch3 pathways through APJ to promote angiogenesis after myocardial infarction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Hypoxia induced high expression of NOTCH3, Jagged-1, Hes1, c-Src, and CSL. Immunofluorescence showed that endothelial cells in hypoxic culture began to express the α-SMA, and the expression of vWF increased with hypoxia. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…TGF-beta1 increased epithelial wound repair, activated EMT (shown by decrease in E-cadherin, and increases in vimentin, SNAIL1/SNAIL2/ZEB1), and increased Notch-1 pathway markers (NOTCH1/JAGGED1/HES1), MMP9, TP63, SCGB1A1. In contrast, CS decreased wound repair and vimentin, NOTCH1/JAGGED1/HES1, MMP9, TP63, SCGB1A1, whereas it activated the initial steps of the EMT (decrease in E-cadherin and increases in SNAIL1/SNAIL2/ZEB1). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Results indicate that there is no evidence for superior crystallized intelligence in HFA, though a jagged profile could be expected both across and within cognitive domains.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…HIGHLIGHTS: Tube formation on Matrigel(TM) and tube formation in co-culture with MSCs are two different stages of angiogenesis. uPA, uPAR, Jagged1, and Notch2 are common upregulated genes for ECs on Matrigel(TM), in co-culture and in dividing/migrating cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To identify the role of Notch signaling in preterm labor, Notch receptors (Notch1-4), its ligands (DLL (Delta-like protein)-1/3/4), Jagged 1/2) and Notch-induced transcription factor Hes1 were assessed during preterm labor. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Endothelial deletion of Fstl1 resulted in activation of Smad1/5/8 signaling and increased BMP/Smad-regulated gene expression of Jagged1, Endoglin, and Gata2 at one week after birth compared with controls. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…If you've bought or built a 3D printer such as a MakerBot only to be confounded by jagged edges, corner lift, top layers that aren't solid, or any of a myriad of other problems that plague 3D printer enthusiasts, then here is the book to help you get past all that and recapture the joy of creative fabrication. …”
Enlace del recurso

“…RESULTS: HNF4α was expressed in the nucleus, and Jagged-1 was diffusely positive in the primitive liver at E10.5; however, the PGP9.5 and CK19 were negative in the fetal liver. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We found that estrogen enhanced the Notch signaling in hBMSCs by promoting the expression of Jagged1. hBMSCs cultured with estrogen resulted in the up-regulation of Notch signaling and increased proliferation and differentiation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Immunofluorescence of first trimester decidual tissues revealed expression of Notch2 receptor and its putative, membrane-anchored interaction partners Jagged1, Delta-like (DLL) 1 and DLL4 in stromal cells whereas other Notch receptors and ligands were absent from these cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Western blot was used to analyze the effect of MSX1 upon Notch1, Jagged1, c-Myc, cleaved PARP, cleaved caspse-3, and cyclin D1 (CCND1). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In an ES cell co-culture assay, Notch signaling induced by Jagged1 or Delta1 was reduced to a similar level in Notch1(lbd)and Notch1 null cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: We report here that there is a general increase in the expression levels of Notch 1, 2, 4, Jagged1, Jagged2, and Delta-like 4 proteins in breast cancers, with simultaneous upregulation of multiple Notch receptors and ligands in a given cancer tissue. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using western blot, real-time RT-PCR, and immunofluorescence staining, we examined aortic tissue samples for the Notch ligands Delta-like 1, Delta-like 4 (DLL1/4), and Jagged1; the Notch receptor 1 (Notch1); the Notch1 intracellular domain (NICD); and Hes1, a downstream target of Notch signaling. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso