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1121por Mezzadri, Giulio, Alexeev, Maxim, Amoroso, Antonio, Baldini Ferroli, Rinaldo, Bertani, Monica, Bettoni, Diego, Bianchi, Fabrizio, Calcaterra, Alessandro, Canale, Nicola, Capodiferro, Manlio, Carassiti, Vito, Cerioni, Stefano, Chai, Junying, Chiozzi, Stefano, Cibinetto, Gianluigi, Cossio, Fabio, Cotta Ramusino, Angelo, De Mori, Francesca, De Stefanis, Marco, Dong, Jing, Evangelisti, Federico, Farinelli, Riccardo, Fava, Luciano, Felici, Giulietto, Fioravanti, Elisa, Garzia, Isabella, Gatta, Maurizio, Greco, Michela, Lavezzi, Lia, Leng, Chongyang, Li, Huaishen, Maggiora, Marco, Malaguti, Roberto, Mangoni, Alessio, Marcello, Simonetta, Melchiorri, Michele, Mignone, Marco, Morello, Gianfranco, Pacetti, Simone, Patteri, Piero, Pellegrino, Jacopo, Pelosi, Alessandro, Rivetti, Angelo, Da Rocha Rolo, Manuel Dioniso, Savrié, Mauro, Scodeggio, Marco, Soldani, Elisabetta, Sosio, Stefano, Spataro, Stefano, Tskhadadze, Edisher, Verma, Sonali, Wheadon, Richard, Yan, Liang“…The anode has been improved w.r.t. the state of the art through a jagged readout that minimize the inter-strip capacitance. …”
Publicado 2019
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1122por Croquelois, Adrien, Domenighetti, Andrea A., Nemir, Mohamed, Lepore, Mario, Rosenblatt-Velin, Nathalie, Radtke, Freddy, Pedrazzini, Thierry“…In the heart, Notch1 signaling takes place in cardiomyocytes and in mesenchymal cardiac precursors and is activated secondary to stimulated Jagged1 expression on the surface of cardiomyocytes. …”
Publicado 2008
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1123“…Particularly remarkable is the formation of fractal electrodes that exhibit interpenetrating jagged elements that consistently avoid electrical contact. …”
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1124“…In the supranasal periphery of the right eye there was a raised white, jagged lesion protruding into the vitreous. Fluorescein angiogram and indocyanine green showed marked venous vasculitis, hypofluorescence, and disc leakage in keeping with birdshot retinochoroiditis. …”
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1125por Tong, Ming, Gonzalez-Navarrete, Howard, Kirchberg, Tyler, Gotama, Billy, Yalcin, Emine B., Kay, Jared, de la Monte, Suzanne M.“…Ethanol-mediated frontal WM atrophy was associated with reduced expression of ASPH, Jagged 1, HES-1, and HIF-1α. These findings link ethanol-induced WM atrophy to inhibition of ASPH expression and signaling through Notch networks, including HIF-1α.…”
Publicado 2017
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1126por Wang, Wei, Liu, Mingxing, Wang, Yang, Yang, Tao, Li, Dongsheng, Ding, Feng, Sun, Hongzhi, Bai, Guang, Li, Qing“…After being subjected to LBP, the expression of Notch and Jagged and Notch targets Hes1 and Hes5 was all upregulated. …”
Publicado 2018
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1127por Martin, Stewart G., Lebot, Marie N., Sukkarn, Bhudsaban, Ball, Graham, Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Storr, Sarah J.“…Using artificial neural networks, genes associated with GPER mRNA expression were identified; these included notch-4 and jagged-1. These results support the prognostic value for determination of GPER expression in breast cancer.…”
Publicado 2018
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1128por Yu, Xueli, Cheng, Gang, Zhang, Lei, Zhang, Yu, Wang, Qing, Zhao, Mengxue, Zeng, Limin, Hu, Youhong, Feng, Linyin“…Mechanism studies revealed that Yhhu4952 promotes OPC differentiation through the inhibition of the Jagged1-Notch1 pathway. These findings suggest Yhhu4952 is potentially useful for proceeding oligodendrocyte differentiation and remyelination.…”
Publicado 2018
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1129“…In mammals, Notch signaling is composed of four receptors (Notch1–4) and five ligands (Dll1-3–4, Jagged1–2) that mainly contribute to the development and maintenance of the central nervous system (CNS). …”
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1130por Pandey, Ashutosh, Harvey, Beth M., Lopez, Mario F., Ito, Atsuko, Haltiwanger, Robert S., Jafar-Nejad, Hamed“…Fringe glycosyltransferases differentially modulate the binding of Notch receptors to Delta/DLL versus Serrate/Jagged ligands by adding GlcNAc to O-linked fucose on Notch epidermal growth factor-like (EGF) repeats. …”
Publicado 2019
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1131por Wu, Na, Cheng, Chong-Jie, Zhong, Jian-Jun, He, Jun-Chi, Zhang, Zhao-Si, Wang, Zhi-Gang, Sun, Xiao-Chuan, Liu, Han“…Bioinformatic analyses and RNA pull-down assays validated enhancer of zeste homolog 2 (EZH2) as a downstream factor of MALAT1 in endothelial cells. Jagged-1, the Notch homolog 1 (NOTCH1) agonist, reversed the MALAT1 deficiency-mediated impairment of angiogenesis. …”
Publicado 2022
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1132“…More recently, an improved understanding of cfDNA fragmentation has provided many emerging fragmentomic markers, including fragment sizes, preferred ends, end motifs, single-stranded jagged ends, and nucleosomal footprints. The intrinsic biological link between activities of various DNA nucleases and characteristic fragmentations has been demonstrated. …”
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1133“…Tregs in the skin express CD25, CTLA-4, GATA-3, and Jagged1 and efficiently proliferate with IL-2 cytokine antibody complex. …”
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1134por Maruthachalam, Bharathikumar Vellalore, Barreto, Kris, Hogan, Daniel, Kusalik, Anthony, Geyer, Clarence Ronald“…These Fabs possessed a high affinity for Notch-1 (sub-nM to mid-nM K(Dapp) values) and exhibited different binding profiles (mono-, bi-or tri-specific) toward Notch/Jagged receptors. Importantly, we showed that screening focused diversity libraries, implementing next-generation sequencing approaches, and fine-tuning the CDR length diversity provided improved binding solutions for Notch-1 recognition. …”
Publicado 2022
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1135por Stenzel, Amanda, Mumme-Monheit, Abigail, Sucharov, Juliana, Walker, Macie, Mitchell, Jennyfer M., Appel, Bruce, Nichols, James T.“…In contrast, her9 also functions redundantly with her6 downstream of Jagged1b-induced Notch activation during dorsoventral craniofacial patterning. …”
Publicado 2022
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1136por Yazdanyar, Amirfarbod, Cai, Charles L., Aranda, Jacob V., Shrier, Eric, Beharry, Kay D.“…Eylea induced soluble VEGFR-1 (sVEGFR-1) coincident with high IGF-I levels and decreased Notch/Jagged-1, demonstrating a functional association. …”
Publicado 2023
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1137“…METHODS: By in situ hybridisation, we investigated the in vivo expression of related genes, namely; Notch 1–3, Delta 1, Jagged 1, Lunatic Fringe, Radical Fringe and Manic Fringe during keratinocyte proliferation and differentiation in humans in basal cell carcinoma, psoriasis and in wound healing experiments, compared with normal adult skin. …”
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1138por Chen, Yixiong, Zheng, Shaoping, Qi, Dan, Zheng, Shaojiang, Guo, Junli, Zhang, Shuling, Weng, Zhihong“…In the present study, we show Notch signaling to be highly activated in a rat model of liver fibrosis induced by carbon tetrachloride (CCl(4)), as indicated by increased expression of Jagged1, Notch3, and Hes1. Blocking Notch signaling activation by a γ-secretase inhibitor, DAPT, significantly attenuated liver fibrosis and decreased the expression of snail, vimentin, and TGF-β1 in association with the enhanced expression of E-cadherin. …”
Publicado 2012
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1139por Wang, Zheng, Jiang, Wei, Feng, Yuanming, Guo, Yang, Cong, Zheng, Song, Bin, Guo, Yu“…Two treatment plans were created for each patient, one was with the new technique called three-isocenter overlap-junction (TIOJ) IMRT and the other was with the three-isocenter jagged-junction (TIJJ) IMRT technique. The comparative study was conducted using the parameters of heterogeneity index (HI), conformity index (CI), and doses to the organs at risk (OARs). …”
Publicado 2013
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1140“…The expression of Notch receptors 1 and 4 and their ligands, Delta1 and 4, Jagged1, and Notch downstream gene target Hes1 was quantified in “nidus” vessels. …”
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