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Mostrando 101 - 120 Resultados de 1,374 Para Buscar '"JAG"', tiempo de consulta: 0.14s Limitar resultados
  1. 101
    “…Gene set enrichment analysis revealed that inhibition of KDM2A down-regulates angiogenic genes with concurrent reduction of Jagged1 (JAG1), NOTCH1 and HEY1 in the NOTCH signaling. …”
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    Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1
  2. 102
    “…The current study was designed to examine the role of Jagged1-Notch signaling in the effect of Ang II during impaired angiogenesis and cardiac hypertrophy. …”
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    Role of Jagged1-Hey1 Signal in Angiotensin II-induced Impairment of Myocardial Angiogenesis
  3. 103
    “…Whereas Jagged1-Notch2 signaling is known to pattern the sensorineural components of the inner ear, its role in middle ear development has been less clear. …”
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    Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear
  4. 104
    “…In addition, miR-141 overexpression inhibited the sphere formation ability of GSCs in vitro and in vivo. Furthermore, Jagged1 may reverse the effect of miR-141; miR-141 was revealed to target the 3′-untranslated region of Jagged1, thereby inhibiting the stemness of GSCs. …”
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    MicroRNA-141 inhibits the self-renewal of glioblastoma stem cells via Jagged1
  5. 105
    “…The role of the Notch ligand Jagged1 in hepatic fibrosis remains to be elucidated. …”
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    Reversal effect of Jagged1 signaling inhibition on CCl4-induced hepatic fibrosis in rats
  6. 106
    “…We set-up a screening strategy based on: protein::protein docking of crystallographic structures of Notch1 with Jagged1; comparative modelling of the Notch2:Jagged2 complex, based on the Notch1::Jagged1 complex; in silico high-throughput screening directed to Notch2 interaction surface of a virtual chemical library containing a large variety of molecules commercially available. …”
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    Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening
  7. 107
    “…Finally, blockade of Jagged1 in FOXP1-knockdown NSCs rescued neuronal differentiation in vitro. …”
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    FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression
  8. 108
    “…Vascular smooth muscle cells (VSMCs) were cyclically stretched on flexible membranes, as quantified via video tracking, demonstrating that the expression of Jagged1, Notch3, and target genes was down-regulated with strain. …”
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    Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis
  9. 109
    “…Mice with tubule-specific deletion of Jag1 or Notch2 (Ksp(cre)/Jag1(flox/flox) and Ksp(cre)/Notch2(flox/flox)) had no kidney-specific alterations at baseline but showed protection from FA-induced kidney fibrosis. …”
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    Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming
  10. 110
    “…The formation of the Jagged1 clusters requires protein production, ER export and endocytosis. …”
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    Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1
  11. 111
    “…It is unclear, however, how Jagged or Delta-like ligands collectively or individually (Jag1, Jag2, Dll1, Dll4) influence differentiation of airway epithelial progenitors. …”
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    Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation
  12. 112
    “…In this study, multiplex genome editing was carried out by the CRISPR/Cas9 system on five homoeologs (BnJAG.A02, BnJAG.C02, BnJAG.C06, BnJAG.A07, and BnJAG.A08) of the JAG gene. …”
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    CRISPR/Cas9-Mediated Multiplex Genome Editing of JAGGED Gene in Brassica napus L.
  13. 113
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    Join or Leave the Club: Jagged1 and Notch2 Dictate the Fate of Airway Epithelial Cells
  14. 114
    “…Jagged1 activates Notch signaling and subsequently promotes osteogenic differentiation in human periodontal ligament cells (hPDLs). …”
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    NOTCH2 participates in Jagged1-induced osteogenic differentiation in human periodontal ligament cells
  15. 115
    “…We investigated the effect of Jagged 1 (Jag1)-mediated Notch signaling activation in the human limbal stem/progenitor cell (LSC) population and the stratification of the limbal epithelium in vitro. …”
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    Role of Jagged1-mediated Notch Signaling Activation in the Differentiation and Stratification of the Human Limbal Epithelium
  16. 116
    “…In Notch signaling, the Jagged1-Notch3 ligand-receptor pairing is implicated for regulating the phenotype maturity of vascular smooth muscle cells. …”
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    Immobilization of Jagged1 Enhances Vascular Smooth Muscle Cells Maturation by Activating the Notch Pathway
  17. 117
    “…A total of 130 differentially expressed proteins were detected by proteomics, and Jagged 1 (JAG1) was predicted as the potential downstream target of CCNB2. …”
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    Cyclin B2 overexpression promotes tumour growth by regulating jagged 1 in hepatocellular carcinoma
  18. 118
    “…The Notch ligand, Jagged-1, plays an essential role in tissue formation during embryonic development of primitive organisms. …”
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    The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells
  19. 119
    “…Among different Notch3 ligands, Jagged1 is most dominant in ovarian cancer, and Notch3 pathway activity correlated with Jagged1 expression level in ovarian carcinoma tissues. …”
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    Jagged1 Expression Regulated by Notch3 and Wnt/β-catenin Signaling Pathways in Ovarian Cancer
  20. 120
    “…In contrast, blockade of a Notch ligand Jagged1 enhanced osteoclastogenesis and immobilized Jagged1-Fc suppressed it. …”
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    Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes
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