“…Additionally, catalpol downregulated the expression of NOTCH1 signaling pathway-related molecules, such as JAGGED1, NOTCH1, NICD1, RBPJ, HES5, and HES1. We further demonstrated that in vitro, catalpol enhanced the differentiation of OPCs into OLs and inhibited NOTCH1 signaling pathway activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, this study highlighted a few distinct morphology cell types, in particular foliar-glandular-like structures, and jagged petal cell walls. Altogether, these data provide a comprehensive histochemical localization of phenolics in living tissues of a violet. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We manually traced the border between the INL and OPL within the 1.5-mm vertical line from the fovea on optical coherence tomography (OCT) images at the initial visit. The jagged ratio (JR), the border length divided by the spline curve length, was calculated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Specifically, LRRN1 exerted its biological functions through the HIF-1α/Notch signaling pathway, and LRRN1 knockdown could dampen Jagged 1-mediated Notch pathway activation. Therefore, LRRN1 could serve as the potential therapeutic or prognostic target for PDAC.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, the inhibition of Notch signalling using the AdR‐dnNotch1 vector suppressed hAMSC differentiation (assessed by epithelial and mesenchymal marker levels), whereas its activation using the AdR‐Jagged1 vector increased differentiation. The above findings indicate Notch signalling mediates the differentiation of hAMSCs into endometrial epithelial cells, thus promoting endometrial regeneration and repair; Notch signalling could have an important function in IUA treatment.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Additionally, with the treatment of Jagged-1, the protective effect of ANGPT2 knockdown on LPS-induced intestinal injury was partly abolished. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It provides ideas for processing jagged edges brought by the BESO algorithm. This paper verified the feasibility of the multisoftware integration method of optimized manufacturing.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…All computations are performed in Bayesian analysis using Gibbs sampling (BUGS) syntax that can be run with Just Another Gibbs Sampling (JAGS) from the R software. A detailed simulation study was used to assess the performance of the proposed parametric proportional hazard model. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Out of 28 genes tested, three were found to be good candidates because of a strong association with corolla shape: RADIALIS, GLOBOSA, and JAGGED. Although the role of these genes in Rhytidophyllum corolla shape variation remains to be confirmed, these findings are a first step towards identifying the genes that have been under selection by pollinators and thus involved in reproductive isolation and speciation in this genus.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This model incorporated the experimentally established multicellular dimensions of the cellular microarray domains, mechanical stress-related activation parameters, and distinct Notch receptor-ligand interactions based on the roles of the Notch ligands Jagged-1 and Delta-like-1. Overall, these studies demonstrate the spatial control of mechanotransduction-associated components, key growth factor and Notch signaling interactions, and point towards a possible role of E-Cadherin in translating intercellular mechanical gradients to downstream Notch signaling.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Stata software, Revman software, JAGS software and the R-based BlandAltmanLeh package, gemtc package and riags package were used to perform this Bayesian network meta-analysis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Suppression of Notch signaling was confirmed in the combined regimen-treated cells, suggesting that inactivation of Jagged1/Notch signaling would probably contribute to the synergistic cytotoxic effect of As(III)+arenobufagin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this review, we focus on the cfDNA fragment characteristics and its potential application, such as fragment length, end motifs, jagged ends, preferred end coordinates, as well as nucleosome footprints, open chromatin region, and gene expression inferred by the cfDNA fragmentation pattern across the genome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the latter half of the study, we applied this condition in music and devised auditory illusions such that melodies of the passages of "Lightly Row," "Cherry Blossoms," and "Jingle Bells" were perceived by listening to "jagged" dichotic tone patterns. The method we described in this paper is simple, and it is possible to easily create auditory illusions in music by applying our method.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We implemented these models using the software Just Another Gibbs Sampler (JAGS) that we interfaced with R with the package rjags. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The posterior distribution of claim data parameters and related parameter estimation are employed with the R language JAGS package to obtain the predicted and simulated loss claim values. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…While the double-stranded method allows jagged end analysis in addition to TOO analysis, it leads to significant methylation bias in urinary cfDNA, which single-stranded methods can overcome.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We demonstrated that in Tgfbr2(PRX-1KO) mice, the failure of joint interzone development resulted from an aberrant persistence of differentiated chondrocytes and failure of Jagged-1 expression. We found that TGF-β receptor II signaling regulates Noggin, Wnt9a, and growth and differentiation factor-5 joint morphogenic gene expressions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Treatment with the p38 inhibitor SB202190 enhanced FGF-2–induced tubular morphogenesis by decreasing apoptosis, increasing DNA synthesis and cell proliferation, and enhancing the kinetics of cell differentiation including increased expression of the Notch ligand Jagged1. Overexpression of dominant negative mutants of the p38-activating kinases MKK3 and MKK6 also supported FGF-2–induced tubular morphogenesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our results indicate that Bmp4 does not mediate the formation of sensory hair and supporting cells within the cristae by directly regulating genes required for prosensory development in the inner ear such as Serrate1 (Jagged1 in mouse), Fgf10, and Sox2. Instead, Bmp4 most likely mediates crista formation by regulating Lmo4 and Msx1 in the sensory region and Gata3, p75Ngfr, and Lmo4 in the non-sensory region of the crista, the septum cruciatum. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso