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1341“…Verification of the miRNA-target genes revealed that Smad5, Jagged 1 and MAPK9 were significantly upregulated, whereas Smad7, BMP and activin membrane-bound inhibitor, and dual-specificity phosphatase 2 were significantly downregulated during FK506-induced osteodifferentiation. …”
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1342por Chakravarti, Bandana, Yang, Jianqi, Ahlers‐Dannen, Katelin E., Luo, Zili, Flaherty, Heather A., Meyerholz, David K., Anderson, Mark E., Fisher, Rory A.“…Double mutant hearts, embryos, and yolk sacs exhibit profound downregulation of Notch1, Jagged 1, and Notch downstream target genes Hey1, Hey2, and Hey1L as well as impaired Notch1 signaling in embryos/hearts. …”
Publicado 2017
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1343por Duygu, Burcu, Poels, Ella M., Juni, Rio, Bitsch, Nicole, Ottaviani, Lara, Olieslagers, Servé, de Windt, Leon J., da Costa Martins, Paula A.“…Mechanistically, miR-199b-5p influenced the expression of three predicted target genes in post-infarcted hearts, dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1a), the notch1 receptor and its ligand jagged1. In conclusion, here we provide evidence supporting that stress-induced miR-199b-5p participates in post-infarct remodeling by simultaneous regulation of distinct target genes.…”
Publicado 2017
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1344“…Relative risk (RR) and 95% credible intervals (CI) were estimated using Markov chain Monte Carlo approach in JAGS. During the study period, the proportion of DOAC prescriptions increased at an average rate of 122% per annum. …”
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1345por Zhu, Peng, Yang, Manli, He, Hao, Kuang, Zhibin, Liang, Mu, Lin, Anxiao, Liang, Song, Wen, Qiyun, Cheng, Zhiqin, Sun, Chaofeng“…The expression levels of NICD, hairy and enhancer of split (Hes)-1, Hes-5 and hairy/enhancer-of-split related with YRPW motif protein 1 (Hey-1) were significantly decreased in H/R-treated cells following curcumin treatment. Treatment with Jagged1 attenuated the effects of curcumin on cell viability, ROS levels and apoptosis; the Notch pathway was also reactivated. …”
Publicado 2019
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1346“…Visually, a systematic overprediction of ventilation within the lung was observed in the CTVIs with respect to the Galligas PET ventilation images, with jagged regions of ventilation in the sagittal and coronal planes. …”
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1347por Mesini, Nicolò, Fiorcari, Stefania, Atene, Claudio Giacinto, Maffei, Rossana, Potenza, Leonardo, Luppi, Mario, Marasca, Roberto“…Notch and its ligands Delta/Jagged exhibit a pivotal role in the crosstalk between leukemic cells and their environment. …”
Publicado 2023
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1348por Gu, Jiao-Jiao, Hou, Yun-Long, Yan, Yi-Hui, Li, Jie, Wei, Ya-Ru, Ma, Kun, Wang, Xiao-Qi, Zhang, Jie-Han, Wang, Dan-Dong, Li, Cui-Ru, Li, Dong-Qi, Sun, Ling-Ling, Gao, Huai-Lin“…In addition, TXL restored endothelial cell functions, including maintaining the balance of vasodilation, acting as a barrier to reduce inflammation, and enhancing endothelial-smooth muscle cell interactions through the Jagged-1/Notch-1/ephrin-B2 signaling pathway. Similar results were observed in vitro. …”
Publicado 2023
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1349por Swarup, Neeti, Cheng, Jordan, Choi, Irene, Heo, You Jeong, Kordi, Misagh, Aziz, Mohammad, Arora, Akanksha, Li, Feng, Chia, David, Wei, Fang, Elashoff, David, Zhang, Liying, Kim, Sung, Kim, Yong, Wong, David T.W.“…The identification of cfDNA features has been made possible by applying novel cfDNA processing techniques that permit the incorporation of ultrashort, ss, and jagged DNA fragments. As a proof of concept using 10 gastric cancer (GC) and 10 noncancer samples, we examined whether ScfDNA characteristics, including fragmentomics, end motif profiles, microbial contribution, and human chromosomal mapping, could differentiate between these two groups. …”
Publicado 2023
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1350por Lian, Haifeng, Jia, Xingfang, Shi, Ning, Xie, Shuyang, Wang, Jian, Wang, Wei, Ma, Fengzhen, Liu, Haiyan, Wang, Aili, Cheng, Xiankui, Liu, Chengxia“…We also found that Notch signaling pathway was abnormally activated and treatment of Notch signaling ligand human Jagged1 peptide downregulated EPHB2 and upregulated EPHB4 in the SW620 cells, as well as promoted the chromatin modification protein Jumonji domain-containing protein-3 (JMJD3) cytonuclear trans-localization with the NICD, which indicated that NICD brought JMJD3 to the EPHB4 enhancer region to decrease the H3K27me3 level. …”
Publicado 2018
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1351por Lin, Qiushi, Chen, Xuesong, Meng, Fanzheng, Ogawa, Kosuke, Li, Min, Song, Ruipeng, Zhang, Shugeng, Zhang, Ziran, Kong, Xianglu, Xu, Qinggang, He, Fuliang, Bai, Xuewei, Sun, Bei, Hung, Mien-Chie, Liu, Lianxin, Wands, Jack, Dong, Xiaoqun“…RESULTS: Through physical interactions with Notch receptors, ligands (JAGs) and regulators (ADAM10/17), ASPH activates Notch cascade to provide raw materials (especially MMPs/ADAMs) for synthesis/release of pro-metastatic exosomes. …”
Publicado 2019
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1352por Yu, Xin-Yi, Zhang, Zhao-Qiang, Huang, Jia-Chang, Lin, Jia-Yu, Cai, Xue-Pei, Liu, Chu-Feng“…Our results showed that IL-7 promoted proliferation and inhibited apoptosis in hPDLCs, promoted the expression of TGF-β, PD-L1, Notch1, Jagged1, and Hes1, and inhibited the levels of hypoxia-inducible factor (HIF)-1α and TCF7, whereas the addition of DAPT effectively reversed these effects. …”
Publicado 2022
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1353“…Western blot analysis was used to evaluate the effects of E-exos on Notch-1, Notch-4, and Jagged-1 expression in HemSCs. RESULTS: E-exos did not differ significantly from hAMSC-exos in terms of morphology, particle size, or surface markers. …”
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1354por Yamamoto, Ryo, Suzuki, Sayuri, Homma, Koichiro, Yamaguchi, Shintaro, Sujino, Tomohisa, Sasaki, Junichi“…Immunofluorescence staining with caspase-3 and leucine-rich repeat-containing G-protein-coupled 5 (LGR5), a specific marker of intestinal stem cell, was conducted to evaluate the injury location and cell types protected by hydrogen. mRNA expressions of LGR5, olfactomedin 4 (OLFM4), hairy and enhancer of split 1, Jagged 2, and Neurogenic locus notch homolog protein 1 were measured by quantitative polymerase chain reaction. …”
Publicado 2022
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1355“…Western blot analysis was performed to detect the protein levels of KLF4, Notch1 and Jagged1. Cell viability and apoptosis were determined by the Cell Counting Kit-8 and flow cytometry, respectively. …”
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1356“…Subsequently, the levels of miR-98 and the mRNA and protein levels of HEY2, Jagged1, Notch1, Hes1, Hes5, β-amyloid precursor protein, B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein in tissues and hippocampal neurons were determined by reverse transcription-quantitative polymerase chain reaction and western blot analyses, respectively. …”
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1357“…Under optimized conditions, the prepared EM-PVP-K30 solid dispersions resembled potato-like, round, and irregular structures with a jagged surface. In contrast, the EM-PRIII solid dispersions were irregular solids with a microporous surface structure. …”
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1358por Spani, Federica, Morigi, Maria Pia, Bettuzzi, Matteo, Scalici, Massimiliano, Carosi, Monica“…Micro-CT 3D volumes showed the surface of some bones as rough, with a jagged appearance, whereas in others the surface appeared very smooth and coherent. …”
Publicado 2020
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1359por Erkasap, Nilufer, Ozyurt, Rumeysa, Ozkurt, Mete, Erkasap, Serdar, Yasar, Fatih, Ihtiyar, Enver, Ciftci, Evrim, Canaz, Funda, Colak, Ertugrul“…No significant changes in the mRNA expression levels of Jagged-1, HIF-1α and TNF receptor 1 were observed. …”
Publicado 2021
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1360“…After treatment with purified surfactin, the MRSA cells clustered together, and cell surface became rough and jagged. Further study showed that reactive oxygen species (ROS) accumulation and cell membrane damage occurred in P. aeruginosa PAO1 and MRSA after treated with fengycin and surfactin, respectively. …”
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