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1“…However, the role of Jagged-2 (JAG2), one of the NOTCH ligands, has not been delineated in colorectal tumorigenesis and drug resistance. …”
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2por Fiaschetti, Giulio, Schroeder, Christina, Castelletti, Deborah, Arcaro, Alexandre, Westermann, Frank, Baumgartner, Martin, Shalaby, Tarek, Grotzer, Michael A“…Finally, the positive correlation of MYC and JAG2 also with aggressive anaplastic tumors and highly metastatic MB stages suggested that high JAG2 expression may be useful as additional marker to identify aggressive MBs.…”
Publicado 2014
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3por Reynolds, Susan D., Hill, Cynthia L., Alsudayri, Alfahdah, Lallier, Scott W., Wijeratne, Saranga, Tan, Zheng Hong, Chiang, Tendy, Cormet-Boyaka, Estelle“…Although specific arrays of Notch receptors regulate cell fate determination, the function of the ligands Jagged1 (JAG1) and JAG2 is unclear. This study examined JAG1 and JAG2 function using human air-liquid-interface cultures that were treated with γ-secretase complex (GSC) inhibitors, neutralizing peptides/antibodies, or WNT/β-catenin pathway antagonists/agonists. …”
Publicado 2022
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4“…In Arabidopsis thaliana, JAGGED (JAG) is a transcription inhibitor that controls the development of leaf polarity and regulates the expression of genes controlling lateral organ formation. …”
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5“…BACKGROUND: Just Another Gibbs Sampling (JAGS) is a convenient tool to draw posterior samples using Markov Chain Monte Carlo for Bayesian modeling. …”
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6por Colombo, Michela, Garavelli, Silvia, Mazzola, Mara, Platonova, Natalia, Giannandrea, Domenica, Colella, Raffaella, Apicella, Luana, Lancellotti, Marialuigia, Lesma, Elena, Ancona, Silvia, Palano, Maria Teresa, Barbieri, Marzia, Taiana, Elisa, Lazzari, Elisa, Basile, Andrea, Turrini, Mauro, Pistocchi, Anna, Neri, Antonino, Chiaramonte, Raffaella“…Myeloma cell-derived Jagged ligands trigger Notch activity in BM stromal cells. …”
Publicado 2020
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7por Siau, Keith, Pelitari, Stavroula, Green, Susi, McKaig, Brian, Rajendran, Arun, Feeney, Mark, Thoufeeq, Mo, Anderson, John, Ravindran, Vathsan, Hagan, Paul, Cripps, Neil, Beales, Ian L P, Church, Karen, Church, Nicholas I, Ratcliffe, Elizabeth, Din, Said, Pullan, Rupert D, Powell, Sharon, Regan, Catherine, Ngu, Wee Sing, Wood, Eleanor, Mills, Sarah, Hawkes, Neil, Dunckley, Paul, Iacucci, Marietta, Thomas-Gibson, Siwan, Wells, Christopher, Murugananthan, Aravinth“…METHODS: Under the oversight of the Joint Advisory Group (JAG), a modified Delphi process was conducted between 2019 and 2020 with multisociety expert representation. …”
Publicado 2023
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8por Kibbie, Jon, Teles, Rosane M. B., Wang, Zhiming, Hong, Patrick, Montoya, Dennis, Krutzik, Stephan, Lee, Seung, Kwon, Ohyun, Modlin, Robert L., Cruz, Daniel“…The gene expression profiles induced in these activated EC, when overlapped with the transcriptomes of human leprosy lesions, identified Jagged1 (JAG1) as a potential regulator of MΦ differentiation. …”
Publicado 2016
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10por Siau, Keith, Beales, Ian L P, Haycock, Adam, Alzoubaidi, Durayd, Follows, Rachael, Haidry, Rehan, Mannath, Jayan, McConnell, Susan, Murugananthan, Aravinth, Ravindran, Srivathsan, Riley, Stuart A, Williams, R N, Trudgill, Nigel John, Veitch, Andrew M“…CONCLUSION: The JAG standards for diagnostic OGD have been updated following evidence-based consensus. …”
Publicado 2022
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12por Silva, Gabriela, Rodrigues, Ana F., Ferreira, Susana, Matos, Carolina, Eleutério, Rute P., Marques, Gonçalo, Kucheryava, Khrystyna, Lemos, Ana R., Sousa, Pedro M. F., Castro, Rute, Barbas, Ana, Simão, Daniel, Alves, Paula M.“…The Notch signaling ligand JAG1 is overexpressed in various aggressive tumors and is associated with poor clinical prognosis. …”
Publicado 2023
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13por Siau, Keith, Pelitari, Stavroula, Green, Susi, McKaig, Brian, Rajendran, Arun, Feeney, Mark, Thoufeeq, Mo, Anderson, John, Ravindran, Vathsan, Hagan, Paul, Cripps, Neil, Beales, Ian L P, Church, Karen, Church, Nicholas I, Ratcliffe, Elizabeth, Din, Said, Pullan, Rupert D, Powell, Sharon, Regan, Catherine, Ngu, Wee Sing, Wood, Eleanor, Mills, Sarah, Hawkes, Neil, Dunckley, Paul, Iacucci, Marietta, Thomas-Gibson, Siwan, Wells, Christopher, Murugananthan, Aravinth“…INTRODUCTION: Joint Advisory Group (JAG) certification in endoscopy is awarded when trainees attain minimum competency standards for independent practice. …”
Publicado 2023
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14por Gjølberg, Torleif Tollefsrud, Wik, Jonas Aakre, Johannessen, Hanna, Krüger, Stig, Bassi, Nicola, Christopoulos, Panagiotis F., Bern, Malin, Foss, Stian, Petrovski, Goran, Moe, Morten C., Haraldsen, Guttorm, Fosse, Johanna Hol, Skålhegg, Bjørn Steen, Andersen, Jan Terje, Sundlisæter, Eirik“…Additionally, we demonstrate that Jagged1 is expressed in mouse and human eyes, and that Jagged1 expression is independent of VEGF signaling in human endothelial cells. …”
Publicado 2023
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15“…Here we show that mouse and human lens progenitor cells endogenously express multiple Jagged1 protein isoforms, including a Jagged1 intracellular domain. …”
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16“…The first is that Sertoli cells express the Jagged1 ligand in mice testes. The second is that the expression level of Jagged1 oscillates in the seminiferous epithelial cycle. …”
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17“…METHODS: We analyzed the expression of Jagged1 and Notch3 in IH specimens, using genetic tools to alter Notch signaling. …”
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18por Xie, Tingting, Wang, Guangya, Ding, Spencer C., Lee, Wing-Shan, Cheng, Suk Hang, Chan, Rebecca W. Y., Zhou, Ze, Ma, Mary-Jane L., Han, Diana S. C., Teoh, Jeremy Y. C., Lam, W. K. Jacky, Jiang, Peiyong, Chiu, Rossa W. K., Chan, K. C. Allen, Lo, Y. M. Dennis“…Single-stranded ends of double-stranded DNA (jagged ends) are more abundant in urinary DNA than in plasma DNA. …”
Publicado 2022
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19por Souilhol, Celine, Tardajos Ayllon, Blanca, Li, Xiuying, Diagbouga, Mannekomba R., Zhou, Ziqi, Canham, Lindsay, Roddie, Hannah, Pirri, Daniela, Chambers, Emily V., Dunning, Mark J., Ariaans, Mark, Li, Jin, Fang, Yun, Jørgensen, Helle F., Simons, Michael, Krams, Rob, Waltenberger, Johannes, Fragiadaki, Maria, Ridger, Victoria, De Val, Sarah, Francis, Sheila E., Chico, Timothy JA, Serbanovic-Canic, Jovana, Evans, Paul C.“…Here, we show using porcine and murine arteries and cultured human coronary artery EC that disturbed flow activates the JAG1-NOTCH4 signaling pathway. Light-sheet imaging revealed enrichment of JAG1 and NOTCH4 in EC of atherosclerotic plaques, and EC-specific genetic deletion of Jag1 (Jag1(ECKO)) demonstrated that Jag1 promotes atherosclerosis at sites of disturbed flow. …”
Publicado 2022
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20por Qiao, Xiaojuan, Ma, Buhuan, Sun, Weiting, Zhang, Ning, Liu, Yang, Jia, Lizhou, Liu, Caixia“…Jagged canonical Notch ligand 1 (JAG1) regulates the progression of many cancers by the Notch signaling pathway, but its role in breast cancer (BC) remains unclear. …”
Publicado 2022
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