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  1. 45001
    “…METHODS: A cross-sectional study using a self-administered questionnaire was conducted for outpatients aged >20 years (N=2,237) at six primary care clinics and hospitals in Japan. The main factors assessed were medical histories of hypertension, salt preferences, reduced salt intakes, and behavior modifications for reducing salt intake. …”
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    Does a medical history of hypertension influence disclosing genetic testing results of the risk for salt-sensitive hypertension, in primary care?
  2. 45002
    “…Learning therapy, which consists of a combination of reading aloud and solving simple arithmetic problems, was developed in Japan as a treatment for Alzheimer’s Disease to improve cognitive functions. …”
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    The beneficial effects of cognitive training with simple calculation and reading aloud in an elderly postsurgical population: study protocol for a randomized controlled trial
  3. 45003
    “…We present a case control study of 196 VKH patients and 209 controls from a highly homogeneous native population of Japan. KIR and HLA class I genes were typed using oligonucleotide hybridization method and analyzed using two-tailed Fisher’s exact probabilities. …”
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    KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease
  4. 45004
    “…The ultrasound (US) machine used for this study was 3D US machine (Nemio-XG: Toshiba, Japan) having four-dimensional (4D) volumetric probe. …”
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    Diagnosis of pathological conditions of kidney by two-dimensional and three-dimensional ultrasonographic imaging in dogs
  5. 45005
    “…The major subgenotype of EV71 isolates circulating in ROK was the C4a strain, which has also appeared in China, Japan and Vietnam. CONCLUSIONS: This surveillance provided valuable data on the epidemic characteristics of EV71 infections in ROK during a 6-year period. …”
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    Epidemiology and virologic investigation of human enterovirus 71 infection in the Republic of Korea from 2007 to 2012: a nationwide cross-sectional study
  6. 45006
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    Phase 3, open-label, randomized study comparing 3-monthly with monthly goserelin in pre-menopausal women with estrogen receptor-positive advanced breast cancer
  7. 45007
    “…The difference of placebo effect between trials conducted in and outside China is -0.273 % (95 % CI [-0.42 %, -0.13 %], p-value is less than 0.001) while after excluding trials conducted in Japan, the difference is -0.203 % (95 % CI [-0.35 %, -0.06 %], p-value is 0.005). …”
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    Differential HbA1c response in the placebo arm of DPP-4 inhibitor clinical trials conducted in China compared to other countries: a systematic review and meta-analysis
  8. 45008
    por Tsuneoka, Hidekazu, Takagi, Masahiko, Murakoshi, Nobuyuki, Yamagishi, Kazumasa, Yokoyama, Yasuhiro, Xu, DongZhu, Sekiguchi, Yukio, Yamasaki, Hiro, Naruse, Yoshihisa, Ito, Yoko, Igarashi, Miyako, Kitamura, Akihiko, Okada, Takeo, Tanigawa, Takeshi, Kuga, Keisuke, Ohira, Tetsuya, Tada, Hiroshi, Aonuma, Kazutaka, Iso, Hiroyasu, Sankai, Tomoko, Umesawa, Mitsumasa, Chei, Choy‐Lye, Yokota, Kimiko, Tabata, Minako, Imano, Hironori, Cui, Renzhe, Ikeda, Ai, Noda, Hiroyuki, Ikehara, Satoyo, Muraki, Isao, Shimizu, Yuji, Ishikawa, Yoshinori, Kiyama, Masahiko, Nakamura, Masakazu, Maeda, Kenji, Ido, Masatoshi, Konishi, Masamitsu, Shimamoto, Takashi, Iida, Minoru, Komachi, Yoshio, Sato, Shinichi, Naito, Yoshihiko, Ozawa, Hideki, Saito, Isao, Sakurai, Susumu, Hitsumoto, Shinichi, Yao, Masayuki
    Publicado 2016
    “…METHODS AND RESULTS: We analyzed standard 12‐lead ECGs of 7178 apparently healthy participants (age range 40–64 years) who underwent health checkups from 1982 to 1986 in the Circulatory Risk in Communities Study, a prospective, large, community‐based cohort study in Japan. ECGs with J point amplitude ≥0.2 mV in the right precordial leads were divided into 3 groups: (1) type 1 BrS, (2) type 2 or 3 BrS (non‐type 1 BrS), and (3) STERP. …”
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    Long‐Term Prognosis of Brugada‐Type ECG and ECG With Atypical ST‐Segment Elevation in the Right Precordial Leads Over 20 Years: Results From the Circulatory Risk in Communities Study (CIRCS)
  9. 45009
    “…SETTING: Tertiary-care emergency departments of five general hospitals in Japan from April 2011 to March 2014. PARTICIPANTS: Eligible patients comprised 1781 patients aged >15 years with acute headache, excluding trauma or toxic causes and patients who presented in an unconscious state. …”
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    New clinical decision rule to exclude subarachnoid haemorrhage for acute headache: a prospective multicentre observational study
  10. 45010
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    Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination
  11. 45011
    “…METHODS: Twenty-four students from Years 2, 3, and 5 at Jichi Medical University in Japan attended a pilot PT session preceded by a brief introduction of its concept and procedures. …”
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    A first report of East Asian students’ perception of progress testing: a focus group study
  12. 45012
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    Efficacy of stereotactic body radiotherapy for hepatocellular carcinoma with portal vein tumor thrombosis/inferior vena cava tumor thrombosis: evaluation by comparison with conventional three-dimensional conformal radiotherapy
  13. 45013
    “…BACKGROUND: Strawberry vein banding virus (SVBV) is a double-stranded DNA plant virus, which has been found in North America, Australia, Brazil, Japan, Europe and several provinces of China. Infected strawberry plants exhibit mild vein-banding symptoms and chlorosis along the veins. …”
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    Complete nucleotide sequence of strawberry vein banding virus Chinese isolate and infectivity of its full-length DNA clone
  14. 45014
    “…BACKGROUND: COPD-related deaths are increasing in Japan, with ~5.3 million people at risk. METHODS: The SHINE was a 26-week, multicenter, randomized, double-blind, parallel-group study that evaluated safety and efficacy of indacaterol (IND)/glycopyrronium (GLY) 110/50 μg once daily (od) compared with GLY 50 μg od, IND 150 μg od, open-label tiotropium (TIO) 18 μg od, and placebo. …”
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    Efficacy and safety of indacaterol/glycopyrronium in Japanese patients with COPD: a subgroup analysis from the SHINE study
  15. 45015
    “…BACKGROUND: It has been customary for working women in Japan to retire when they marry and to devote themselves to household work as well as having children. …”
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    What inhibits working women with mental disorders from returning to their workplace?-A study of systematic re-employment support in a medical institution
  16. 45016
    “…Body composition values were taken from the electronic medical records of InBody730 (a vertical, segmental, multi-frequency analyzer by InBody, Tokyo Japan) testing done at the initial visit. Various parameters of the body composition values of female in the non-suidoku and suidoku groups (splashing sound and edema groups) were compared: there were too few male patients to provide significance. …”
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    Bioelectrical Impedance Analysis (BIA) of the association of the Japanese Kampo concept “Suidoku” (fluid disturbance) and the body composition of women
  17. 45017
    “…TRIAL REGISTRATION: GHLIQUID-1516, GHLIQUID-1517, Japan Pharmaceutical Information Center Clinical trial registration: JapicCTI-050132. …”
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    The influence of a long-term growth hormone treatment on lipid and glucose metabolism: a randomized trial in short Japanese children born small for gestational age
  18. 45018
    “…Salix integra is a shrub willow native to northeastern China, Japan, Korea, and Primorsky Krai in the far southeast of Russia, and has been identified as cadmium (Cd)-accumulating trees in recent years. …”
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    Transcriptome Sequencing and Expression Analysis of Cadmium (Cd) Transport and Detoxification Related Genes in Cd-Accumulating Salix integra
  19. 45019
    “…Most reports came from HTLV-1-endemic countries, mainly Japan (n = 30) and Brazil (n = 10). These reports described a total of 270 families in which more than one relative had HTLV-1-associated diseases. …”
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    Family Aggregation of Human T-Lymphotropic Virus 1-Associated Diseases: A Systematic Review
  20. 45020
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    Long-term outcome and chest pain in patients with true versus non-true bifurcation lesions treated with second-generation drug-eluting stents in the TWENTE trial
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