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  1. 45921
    “…Herein, we report the creation and characterization of a novel Brca1 mutant rat model harboring the germline L63X mutation, which mimics a founder mutation in Japan, through CRISPR‐Cas9–based genome editing. …”
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    Brca1 (L63X) (/+) rat is a novel model of human BRCA1 deficiency displaying susceptibility to radiation‐induced mammary cancer
  2. 45922
    “…One hundred four patients were randomized in Japan (data cutoff, October 26, 2020; median follow‐up, 11.8 [range, 1.1–26.9] months). …”
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    Lenvatinib plus pembrolizumab in Japanese patients with endometrial cancer: Results from Study 309/KEYNOTE‐775
  3. 45923
    “…BACKGROUND: Soft coagulation using the VIO soft coagulation system is used to treat minor lung air leaks during pulmonary resection in Japan. We previously reported that it has a similar effect as the air leak treatment with fibrin glue. …”
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    Clinical effect of soft coagulation for air leak treatment during pulmonary lobectomy
  4. 45924
    “…This longitudinal cohort study used data from the Tokyo Teen Cohort study in Tokyo, Japan, for two years between October 2012 and January 2015. …”
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    Bidirectional relationship of problematic Internet use with hyperactivity/inattention and depressive symptoms in adolescents: a population-based cohort study
  5. 45925
    por Hou, Weilu, Shi, Qin, Guo, Liquan
    Publicado 2022
    “…Moreover, in both the prepandemic and postpandemic years, the FTITAs to North America, Japan/South Korea, Europe, and Southeast Asia are significantly higher than those to Oceania, Middle East, South America, and Africa. …”
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    Impacts of COVID-19 pandemic on foreign trade intermodal transport accessibility: Evidence from the Yangtze River Delta region of mainland China
  6. 45926
    “…We retrospectively analyzed a combined dataset from three large-scale registries of hospitalized patients with HF in Japan (NARA-HF, WET-HF, and REALITY-AHF) and patients diagnosed with HF with reduced or mildly reduced left ventricular ejection fraction (HFr/mrEF) before admission. …”
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    Association between class of foundational medication for heart failure and prognosis in heart failure with reduced/mildly reduced ejection fraction
  7. 45927
    “…Patients with post-stroke aphasia in Japan are increasing due to population aging and the advancement of medical treatment. …”
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    Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia
  8. 45928
    “…For example, all the studies done in Japan showed an increase in the consumption of snacks and sweets, leading to weight gain in the patients. …”
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    How did lockdown and social distancing policies change the eating habits of diabetic patients during the COVID-19 pandemic? A systematic review
  9. 45929
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    Efficacy of international web‐based educational intervention in the detection of high‐risk flat and depressed colorectal lesions higher (CATCH project) with a video: Randomized trial
  10. 45930
    “…We conducted this population-based retrospective study in Nara Prefecture, Japan. The Nara Prefectural Government implemented a screening protocol for COVID-19 comprising the following symptom criteria (fever, cough, sore throat, headache, malaise, dysgeusia, or anosmia) and epidemiological criteria (contact history with confirmed COVID-19 cases or people with upper respiratory symptoms, or travel to areas with high infection rate). …”
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    Sensitivity and specificity analyses of COVID-19 screening protocol for emergency medical services: A STARD-compliant population-based retrospective study
  11. 45931
    “…METHODS: Using liquid chromatography, we analyzed IgG ACPA VDG profiles in 7 different cohorts from Japan, Canada, The Netherlands, and Sweden. We assessed 106 healthy individuals, 228 individuals with presymptomatic RA, 277 individuals with arthralgia, 307 patients with new‐onset/early RA, and 117 RA patients after prespecified treatment regimens. …”
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    IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross‐Sectional Study Encompassing ~1,500 Samples
  12. 45932
    “…Nivolumab, a monoclonal antibody against human programmed death 1, was approved for the treatment of melanoma in July 2014 in Japan. Because the Japanese phase II studies (ONO‐4538‐02, ONO‐4538‐08) enrolled small numbers of melanoma patients, post‐marketing surveillance (PMS; JapicCTI‐163 272) was conducted to collect safety data in a larger patient population. …”
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    Safety and effectiveness of nivolumab in Japanese patients with malignant melanoma: Final analysis of a post‐marketing surveillance
  13. 45933
    “…SETTING: Database of the Recurrence Prevention Committee, Japan Obstetric Compensation System for Cerebral Palsy. …”
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    Correlation between fetal heart rate evolution patterns and magnetic resonance imaging findings in severe cerebral palsy: A longitudinal study
  14. 45934
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    Prevalence of missed lesions in patients with inadequate bowel preparation through a very early repeat colonoscopy
  15. 45935
    “…Nonpsychiatric data (20 binary traits [mainly nonpsychiatric complex disorders] and 34 quantitative traits [mainly laboratory examinations and physical characteristics]) were obtained from Biobank Japan and UK Biobank for EAS and EUR samples, respectively. …”
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    Shared genetic components between metabolic syndrome and schizophrenia: Genetic correlation using multipopulation data sets
  16. 45936
    “…CONCLUSIONS: This was the first time that the raphe nuclei, anterior nuclei, and dorsomedial nuclei were successfully visualised using the first hemispherical brain PET. TRIAL REGISTRATION : Japan Registry of Clinical Trials, jRCTs032210086, Registered 13 May 2021, https://jrct.niph.go.jp/latest-detail/jRCTs032210086.…”
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    Small nuclei identification with a hemispherical brain PET
  17. 45937
    “…To this end, we compared the reliability of gradient boosting decision tree (GBDT) and logistic regression (LR) models using data obtained from the Kokuho-database of the Osaka prefecture, Japan. To develop the models, we focused on 16 predictors from health checkup data from April 2013 to December 2014. …”
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    Gradient boosting decision tree becomes more reliable than logistic regression in predicting probability for diabetes with big data
  18. 45938
    “…This study aimed to investigate the relationship between AT activity levels and long-term outcomes in patients with TBI; this was a sub-analysis of a prior study that collected blood samples of trauma patients prospectively in a tertiary care center in Kawaguchi City, Japan. We included patients with isolated TBI (iTBI) aged ≥16 years admitted directly to our hospital within 1 h after injury between April 2018 and March 2021. …”
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    Antithrombin activity levels for predicting long-term outcomes in the early phase of isolated traumatic brain injury
  19. 45939
    “…DESIGN: A population-based cohort study conducted using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), a national claims database managed by the Japanese Ministry of Health, Labour, and Welfare (MHLW). …”
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    Incidence and Clinical Practice of Exudative Age-related Macular Degeneration: A Nationwide Population-Based Cohort Study
  20. 45940
    “…OBJECTIVE: Pneumonia is a disease with high morbidity and mortality among older individuals in Japan. In practice, most older patients with pneumonia are not required ventilatory management and are not necessarily in critical respiratory condition. …”
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    Reduced renal function is associated with prolonged hospitalization in frail older patients with non-severe pneumonia
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