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  1. 46001
    “…BACKGROUND: The standard preoperative treatment for resectable locally advanced esophageal squamous cell carcinoma (LAESCC) in Japan is docetaxel, cisplatin (CDDP), and 5-fluorouracil. …”
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    Safety and short-term efficacy of preoperative FOLFOX therapy in patients with resectable esophageal squamous cell carcinoma who are ineligible for cisplatin
  2. 46002
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    Impact of long-term optimizing atrioventricular delay using device-based algorithms on cardiac resynchronization therapy
  3. 46003
    “…Using the EPISENS-M, a longitudinal WBE study was conducted between 28 May 2020 and 16 June 2022 in Sapporo City, Japan, revealing a strong correlation (Pearson’s r = 0.94) between C(RNA) and the newly COVID-19 cases reported by intensive clinical surveillance. …”
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    Wastewater-based prediction of COVID-19 cases using a highly sensitive SARS-CoV-2 RNA detection method combined with mathematical modeling
  4. 46004
    “…However, the magnitude of the impact may vary across countries; therefore, we conducted an analysis and modeling study of this impact in Japan. PATIENTS AND METHODS: We compared the clinicopathological features of breast cancers between the nonpandemicgroup (April 1, 2019 to October 31, 2019) and the pandemic group (April 1, 2020 to October 31, 2020). …”
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    Delayed Diagnosis and Prognostic Impact of Breast Cancer During the COVID-19 Pandemic
  5. 46005
    “…METHODS: The present study is a secondary analysis of a multicenter prospective observational study examining the effectiveness and safety of opioids for dyspnea in patients with cancer in Japan. For this secondary analysis, patients with lung cancer with a documented dyspnea Numerical Rating Scale (NRS) at baseline were included. …”
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    Effectiveness and safety of opioids for dyspnea in patients with lung cancer: secondary analysis of multicenter prospective observational study
  6. 46006
    “…CONCLUSION: In this large-scale study, both T2-high and T2-low severe asthma patients in Japan were shown to have a high disease burden and high economic burden, suggesting an unmet treatment need.…”
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    A Retrospective Claims Database Study to Clarify Disease Burden of Severe Asthma Patients with Type 2 High or Low Inflammation
  7. 46007
    “…BACKGROUND: Primary spontaneous pneumothorax occasionally relapses, even after bullectomy; therefore, coverage of the bullectomy staple line for pleural reinforcement is common in Japan. However, the appropriate covering materials have not yet been determined. …”
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    The effect of polyglycolic acid sheet in preventing postoperative recurrent pneumothorax: a prospective cohort study
  8. 46008
    “…METHODS: Dyads of people with PD and their primary caregivers were identified from the Adelphi Parkinson’s Disease Specific Program (DSP™) using real-world data from the United States, Japan and five European countries. Questionnaires were used to capture measures of clinical burden (people with PD) and caregiver burden (caregivers). …”
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    Impact of advanced Parkinson’s disease on caregivers: an international real-world study
  9. 46009
    “…Serum PIVKA-II was assessed by chemiluminescence immunoassay on the Lumipulse(®) G600 II platform (Fujirebio, Tokyo, Japan). In the overall cohort (n = 1187), PIVKA-II showed an area under the curve (AUC) of 0.802 for HCC detection. …”
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    Identification of the Best Cut-Off Value of PIVKA-II for the Surveillance of Patients at Risk of Hepatocellular Carcinoma Development
  10. 46010
    “…However, it has not been evaluated in Japan, where the total cases and death toll are lower than the rest of the world. …”
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    Performance evaluation of the Ortho VITROS SARS-CoV-2 Spike-Specific Quantitative IgG test by comparison with the surrogate virus neutralizing antibody test and clinical assessment
  11. 46011
    “…Subgroup analysis based on country was highest in Pakistan (97%, 95% CI: 96, 98) and lowest in Japan (12%, 95% CI: 9, 15). Subgroup analysis based on country showed that studies in Saudi Arabia (I(2) = 99.41%, p value < 0.001), Ethiopia (I(2) = 72.6%, p value < 0.001), and India (I(2) = 98.04%, p value < 0.001) had significant heterogeneity. …”
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    Prevalence of computer vision syndrome: a systematic review and meta-analysis
  12. 46012
    “…Phylogenetic analysis showed that strains from the study have genetic relation with circulating strains in Japan, China and Croatia. Seven out of the twenty sequences showed 180-nucleotide duplication and eleven sequences showed 111-nucleotide duplication. …”
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    The emergence of human metapneumovirus G gene duplication in hospitalized patients with respiratory tract infection, India, 2016–2018
  13. 46013
    “…BACKGROUND: D3 lymph node dissection is recommended for patients with advanced sigmoid and rectal cancer in Japan. This trial aimed to investigate the feasibility of indocyanine green (ICG) as a tracer to increase the nodal harvest during D3 lymph node dissection in patients with sigmoid and rectal cancer. …”
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    Indocyanine green for radical lymph node dissection in patients with sigmoid and rectal cancer: randomized clinical trial
  14. 46014
    por Ganesh, Durga, Lin, Shawn R.
    Publicado 2022
    “…RESULTS: Fourteen studies were included, originating from Asia (Japan, Singapore, Myanmar, Iran, South Korea, China), Europe (Germany, United Kingdom, Portugal), Australia, and North America (United States). …”
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    Global metrics on ocular biometry: representative averages and standard deviations across ten countries from four continents
  15. 46015
    “…Luke’s International Hospital in Tokyo, Japan, from 2005 to 2018. All participants who underwent voluntary health check-ups were included. …”
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    Slight religiosity associated with a lower incidence of any fracture among healthy people in a multireligious country
  16. 46016
    “…This study collected data from a backgrounding operation in Miyazaki, Japan, that included 153 calves aged 3–4 months. …”
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    Assessment of Ventral Tail Base Surface Temperature for the Early Detection of Japanese Black Calves with Fever
  17. 46017
    “…Regarding SNP-total and colorectal cancer association, 4543 cancer cases and 14,224 controls and 7936 colorectal cancer cases and 38,042 controls, respectively were included from the Japanese Consortium of Genetic Epidemiology and other studies in Japan. There was no significant association between the genetically predicted plasma 25-hydroxyvitamin D concentration and total or colorectal cancer in any of the MR analyses. …”
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    Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach
  18. 46018
    “…A total of 400 elderly patients with osteoarthritis of the hip and knee will be recruited from five institutions in Japan. Patients of 65 years or older with osteoarthritis-related pain will be registered and randomly assigned to acetaminophen, loxoprofen or celecoxib with 2:1:1 allocation. …”
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    Protocol for the RETHINK study: a randomised, double-blind, parallel-group, non-inferiority clinical trial comparing acetaminophen and NSAIDs for treatment of chronic pain in elderly patients with osteoarthritis of the hip and knee
  19. 46019
    “…A comparison with 31 K. michiganensis genomes that are available in the NCBI database showed that the closest phylogenetic relatives of K. michiganensis 23999A2 are an environmental isolate from soil in South Korea and a clinical isolate from human sputum in Japan. Finally, a pan-genome analysis showed a large accessory genome of the strain as well as the great genomic plasticity of the K. michiganensis species. …”
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    The Emerging Nosocomial Pathogen Klebsiella michiganensis: Genetic Analysis of a KPC-3 Producing Strain Isolated from Venus Clam
  20. 46020
    “…Exposure to PM2.5 collected at Yokohama, Japan also exacerbated movement disorder after ischemic stroke. …”
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    Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation
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