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  1. 47581
    “…Naldemedine, an oral, peripherally acting μ-opioid receptor antagonist (PAMORA), is approved in Japan, the United States, and the European Union for treatment of OIC in adult patients. …”
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    Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy: A Subgroup Analysis of Patients ≥ 65 Years of Age
  2. 47582
    por Halliday, H L
    Publicado 2008
    “…Working with him was Tetsuro Fujiwara who 2 years later, after returning to Japan, published the seminal article reporting the responses of 10 preterm infants with RDS to a bolus of modified bovine surfactant. …”
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    Surfactants: past, present and future
  3. 47583
    “…METHODS: We evaluated the association between n-3/n-6 PUFA ratio and acute coronary syndrome (ACS) in three BMI-based groups (< 25: low BMI, 25–27.5: moderate BMI, and ≥ 27.5: high BMI) that included 1666 patients who visited the cardiovascular medicine departments of five hospitals located in urban areas in Japan. RESULTS: The prevalence of ACS events was 9.2, 7.3, and 10.3% in the low, moderate, and high BMI groups, respectively. …”
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    Association between the ratio of serum n-3 to n-6 polyunsaturated fatty acids and acute coronary syndrome in non-obese patients with coronary risk factor: a multicenter cross-sectional study
  4. 47584
    por Grein, Jonathan, Ohmagari, Norio, Shin, Daniel, Diaz, George, Asperges, Erika, Castagna, Antonella, Feldt, Torsten, Green, Gary, Green, Margaret L., Lescure, François-Xavier, Nicastri, Emanuele, Oda, Rentaro, Yo, Kikuo, Quiros-Roldan, Eugenia, Studemeister, Alex, Redinski, John, Ahmed, Seema, Bernett, Jorge, Chelliah, Daniel, Chen, Danny, Chihara, Shingo, Cohen, Stuart H., Cunningham, Jennifer, D’Arminio Monforte, Antonella, Ismail, Saad, Kato, Hideaki, Lapadula, Giuseppe, L’Her, Erwan, Maeno, Toshitaka, Majumder, Sumit, Massari, Marco, Mora-Rillo, Marta, Mutoh, Yoshikazu, Nguyen, Duc, Verweij, Ewa, Zoufaly, Alexander, Osinusi, Anu O., DeZure, Adam, Zhao, Yang, Zhong, Lijie, Chokkalingam, Anand, Elboudwarej, Emon, Telep, Laura, Timbs, Leighann, Henne, Ilana, Sellers, Scott, Cao, Huyen, Tan, Susanna K., Winterbourne, Lucinda, Desai, Polly, Mera, Robertino, Gaggar, Anuj, Myers, Robert P., Brainard, Diana M., Childs, Richard, Flanigan, Timothy
    Publicado 2020
    “…Of the 53 patients whose data were analyzed, 22 were in the United States, 22 in Europe or Canada, and 9 in Japan. At baseline, 30 patients (57%) were receiving mechanical ventilation and 4 (8%) were receiving extracorporeal membrane oxygenation. …”
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    Compassionate Use of Remdesivir for Patients with Severe Covid-19
  5. 47585
    “…INTRODUCTION: Dapagliflozin is an orally active inhibitor of sodium-glucose co-transporter 2 (SGLT2) that is indicated for use in adults with type 1 diabetes (T1DM) (with a body mass index (BMI) of at least 27 kg/m(2) in Europe, no such BMI limit in Japan), when insulin alone does not provide adequate glycaemic control. …”
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    Adverse Changes in HbA1c, Body Weight and Insulin Use in People with Type 1 Diabetes Mellitus Following Dapagliflozin Discontinuation in the DEPICT Clinical Trial Programme
  6. 47586
    “…METHODS: This prospective crossover study was conducted from April 2017 to March 2019 in a public medical university in Japan. In total, 209 medical students (4th and 5th grade, mean age of 23.7 ± 2.0 years) without clinical ETI experience were recruited. …”
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    Lower maximum forces on oral structures when using gum-elastic bougie than when using endotracheal tube and stylet during both direct and indirect laryngoscopy by novices: a crossover study using a high-fidelity simulator
  7. 47587
    “…TRIAL REGISTRATION: The study was registered with the University Hospital Medical Information Network (UMIN000036202) on 1 April 2019 and with the Japan Registry of Clinicla Trials (jRCTs071180061) on 14 March 2019.…”
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    The effect of luseogliflozin on bone microarchitecture in older patients with type 2 diabetes: study protocol for a randomized controlled pilot trial using second-generation, high-resolution, peripheral quantitative computed tomography (HR-pQCT)
  8. 47588
    “…The patients were assigned to receive reaching exercise intervention with the robot (Yaskawa Electric Co., Ltd. Fukuoka, Japan) for 2 weeks at 15 min/day in addition to regular occupational therapy for 40 min/day. …”
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    Reaching exercise for chronic paretic upper extremity after stroke using a novel rehabilitation robot with arm-weight support and concomitant electrical stimulation and vibration: before-and-after feasibility trial
  9. 47589
    “…Internal medicine (Tokyo, Japan) vol. 57,23 (2018): 3407–3412…”
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    SUN-299 Flash Glucose Sensor Monitoring for Patients with Endogenous Hyperinsulinaemic Hypoglycaemia
  10. 47590
    “…In recent years, awareness of eradication therapy has increased in Japan. As H. pylori infections decrease, the proportion of gastric cancers arising from H. pylori uninfected gastric mucosa will increase. …”
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    Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients
  11. 47591
    “…Both studies were conducted at sites in Japan. Participants were healthy male volunteers, aged ≥ 20–40 years. …”
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    Bioequivalence of a Newly Developed Dabigatran Etexilate Tablet Versus the Commercial Capsule and Impact of Rabeprazole-Induced Elevated Gastric pH on Exposure in Healthy Subjects
  12. 47592
    “…recptno=R000031377, and changed to jRCTs041180063, registered on 30 July 2019; as a result of the revision of the domestic law in 2018 in Japan.…”
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    Study protocol for daiobotanpito combined with antibiotic therapy for treatment of acute diverticulitis: a study protocol for a randomized controlled trial
  13. 47593
    “…METHODS: Patients with T2D aged ≥ 18 years initiating BI or GLP-1 RA therapy following treatment with OADs were selected from real-world data (RWD) retrieved from a large electronic medical record database in Japan, using data from 01 January 2010 to 30 June 2019. …”
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    A Real-World Observational Study Evaluating the Probability of Glycemic Control with Basal Insulin or Glucagon-Like Peptide-1 Receptor Agonist in Japanese Patients with Type 2 Diabetes
  14. 47594
    “…BACKGROUND: Ripasudil is approved in Japan for glaucoma or ocular hypertension (OH) when other treatments are ineffective or cannot be administered. …”
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    Safety and efficacy of ripasudil in Japanese patients with glaucoma or ocular hypertension: 12-month interim analysis of ROCK-J, a post-marketing surveillance study
  15. 47595
    “…METHODS: Forty-two college students in the greater Tokyo area of Japan participated in the study by creating dietary diaries online through a smartphone app and then followed/interacted with each other using social media for 7 consecutive days in September to November 2017. …”
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    Promoting Healthy Eating Habits for College Students Through Creating Dietary Diaries via a Smartphone App and Social Media Interaction: Online Survey Study
  16. 47596
    por Kuchta, Kenny, Cameron, Silke
    Publicado 2020
    “…BACKGROUND: In contrast to Western medicine which currently offers no approved pharmacotherapy options for cachexia, in Japan multi-component extracts of medicinal plants are used with coverage by the national health insurance. …”
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    Phytotherapy for Cachexia: Where Do We Stand?
  17. 47597
    “…Cross-sectional epidemiological data obtained from a questionnaire survey (conducted in October 2017) of a community affected by the 2011 Great East Japan Earthquake (GEJE) was analyzed to evaluate the relationships. …”
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    The Impact of Health Consciousness on the Association Between Walking Durations and Mental Health Conditions After a Disaster: a Cross-Sectional Study
  18. 47598
    “…Registered September 20, 2019, https://clinicaltrials.gov/ct2/show/study/NCT04097444/ Japan Registry of Clinical Trials jRCTs041190072. …”
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    Protocol of the QUATTRO-II study: a multicenter randomized phase II study comparing CAPOXIRI plus bevacizumab with FOLFOXIRI plus bevacizumab as a first-line treatment in patients with metastatic colorectal cancer
  19. 47599
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    Dysbalanced sex hormone status is an independent predictor of decompensation and mortality in patients with liver cirrhosis
  20. 47600
    “…The bonding procedure was performed using Panavia V5 (Kuraray, Japan) with a bonding area of 0.785 mm(2). For each group, half of the specimens were subjected to 5000 thermal cycles (subgroup T), while the other half did not receive thermocycling (subgroup N) (n = 10). …”
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    Effects of remaining dentin thickness on the bond strength of bleached dentin
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