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  1. 47801
    por Bai, Xue, Shaheen, Ahmed, Grieco, Charlotte, d’Arienzo, Paolo D., Mina, Florentia, Czapla, Juliane A., Lawless, Aleigha R., Bongiovanni, Eleonora, Santaniello, Umberto, Zappi, Helena, Dulak, Dominika, Williamson, Andrew, Lee, Rebecca, Gupta, Avinash, Li, Caili, Si, Lu, Ubaldi, Martina, Yamazaki, Naoya, Ogata, Dai, Johnson, Rebecca, Park, Benjamin C., Jung, Seungyeon, Madonna, Gabriele, Hochherz, Juliane, Umeda, Yoshiyasu, Nakamura, Yasuhiro, Gebhardt, Christoffer, Festino, Lucia, Capone, Mariaelena, Ascierto, Paolo Antonio, Johnson, Douglas B., Lo, Serigne N., Long, Georgina V., Menzies, Alexander M., Namikawa, Kenjiro, Mandala, Mario, Guo, Jun, Lorigan, Paul, Najjar, Yana G., Haydon, Andrew, Quaglino, Pietro, Boland, Genevieve M., Sullivan, Ryan J., Furness, Andrew J.S., Plummer, Ruth, Flaherty, Keith T.
    Publicado 2023
    “…METHODS: This multicenter, retrospective cohort study was conducted in 15 melanoma centers in Australia, China, Germany, Italy, Japan, UK, and US. We included adult patients with resected stage III BRAF V600-mutant melanoma who received either adjuvant D/T or PD-1 between Jul 2015 and Oct 2022. …”
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    Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective cohort study
  2. 47802
    “…An additional aphelinid parasitoid, Encarsia nipponica Silvestri, native to Japan and China, was accidentally introduced and found to attack both citrus whiteflies on the islands. …”
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    A Survey in Hawaii for Parasitoids of Citrus Whiteflies (Hemiptera: Aleyrodidae), for Introduction into Greece
  3. 47803
    “…METHODS: This study is a multicenter, randomized, double-blind, placebo-controlled study conducted in Japan, South Korea and Vietnam. SARS-CoV-2-positive patients, aged 12–70 years old, received ensitrelvir 125 mg PO (after 375 mg PO loading dose on Day 1 only), 250 mg PO (after 750 mg PO loading dose on Day 1 only) or placebo, once daily for 5 days, and were followed by Day 21 from start of treatment to analyze the proportion of patients presenting with taste or smell disorder. …”
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    549. Ensitrelvir for the Treatment of COVID-19 Infection: Evaluation of Taste Disorder and Smell Disorder in the Phase 3 Part of the Phase 2/3 SCORPIO-SR Randomized Controlled Trial
  4. 47804
    “…BACKGROUND: Japan has four types of intensive care units (ICUs) that are divided into two categories according to the management fee charged per day: ICU management fees 1 and 2 (ICU1/2) (equivalent to high-intensity staffing) and 3 and 4 (ICU3/4) (equivalent to low-intensity staffing). …”
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    Intensive care unit mortality and cost-effectiveness associated with intensivist staffing: a Japanese nationwide observational study
  5. 47805
    “…Mean levels in Fallujah were also much higher than the mean of measurements reported from Japan, Brazil, Sweden and Slovenia (0.04 ppm SD 0.02). …”
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    Uranium and other contaminants in hair from the parents of children with congenital anomalies in Fallujah, Iraq
  6. 47806
    por Fox, Bernard A, Schendel, Dolores J, Butterfield, Lisa H, Aamdal, Steinar, Allison, James P, Ascierto, Paolo Antonio, Atkins, Michael B, Bartunkova, Jirina, Bergmann, Lothar, Berinstein, Neil, Bonorino, Cristina C, Borden, Ernest, Bramson, Jonathan L, Britten, Cedrik M, Cao, Xuetao, Carson, William E, Chang, Alfred E, Characiejus, Dainius, Choudhury, A Raja, Coukos, George, de Gruijl, Tanja, Dillman, Robert O, Dolstra, Harry, Dranoff, Glenn, Durrant, Lindy G, Finke, James H, Galon, Jerome, Gollob, Jared A, Gouttefangeas, Cécile, Grizzi, Fabio, Guida, Michele, Håkansson, Leif, Hege, Kristen, Herberman, Ronald B, Hodi, F Stephen, Hoos, Axel, Huber, Christoph, Hwu, Patrick, Imai, Kohzoh, Jaffee, Elizabeth M, Janetzki, Sylvia, June, Carl H, Kalinski, Pawel, Kaufman, Howard L, Kawakami, Koji, Kawakami, Yutaka, Keilholtz, Ulrich, Khleif, Samir N, Kiessling, Rolf, Kotlan, Beatrix, Kroemer, Guido, Lapointe, Rejean, Levitsky, Hyam I, Lotze, Michael T, Maccalli, Cristina, Maio, Michele, Marschner, Jens-Peter, Mastrangelo, Michael J, Masucci, Giuseppe, Melero, Ignacio, Melief, Cornelius, Murphy, William J, Nelson, Brad, Nicolini, Andrea, Nishimura, Michael I, Odunsi, Kunle, Ohashi, Pamela S, O'Donnell-Tormey, Jill, Old, Lloyd J, Ottensmeier, Christian, Papamichail, Michael, Parmiani, Giorgio, Pawelec, Graham, Proietti, Enrico, Qin, Shukui, Rees, Robert, Ribas, Antoni, Ridolfi, Ruggero, Ritter, Gerd, Rivoltini, Licia, Romero, Pedro J, Salem, Mohamed L, Scheper, Rik J, Seliger, Barbara, Sharma, Padmanee, Shiku, Hiroshi, Singh-Jasuja, Harpreet, Song, Wenru, Straten, Per Thor, Tahara, Hideaki, Tian, Zhigang, van Der Burg, Sjoerd H, von Hoegen, Paul, Wang, Ena, Welters, Marij JP, Winter, Hauke, Withington, Tara, Wolchok, Jedd D, Xiao, Weihua, Zitvogel, Laurence, Zwierzina, Heinz, Marincola, Francesco M, Gajewski, Thomas F, Wigginton, Jon M, Disis, Mary L
    Publicado 2011
    “…In late 2009 and 2010 the Society for Immunotherapy of Cancer (SITC), convened an "Immunotherapy Summit" with representatives from immunotherapy organizations representing Europe, Japan, China and North America to discuss collaborations to improve development and delivery of cancer immunotherapy. …”
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    Defining the critical hurdles in cancer immunotherapy
  7. 47807
    “…Of these, 4 were related to an exposure to x-ray radiation from an industrial radiography incident, 11 were related to a transportation accident involving potential contamination with radioactive material, and 10 were related to the Fukushima Daiichi Japan nuclear reactor disaster. Public health, hazardous materials, or hospital radiation safety staff were involved in responding to each of these events. …”
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    Surveillance for Radiation-Related Exposures Reported to the National Poison Data System
  8. 47808
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    The effects of low doses of proton, iron or silicon radiation on spatial learning in a mouse model of Alzheimer's disease
  9. 47809
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    The effect of X-rays and C-ions on pluripotent embryonic stem cells
  10. 47810
    por Grabham, Peter, Sharma, Preety
    Publicado 2014
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    Acute effects of ionizing radiation on human endothelial barrier function
  11. 47811
    “…We collated and analysed data from hospital records regarding the cause of death of 18,385 patients with diabetes who died in 282 medical institutions throughout Japan over the 10‐year period between 1991 and 2000. …”
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    Causes of death in Japanese diabetics: A questionnaire survey of 18,385 diabetics over a 10‐year period
  12. 47812
    “…METHODS: This randomized, open-label, phase III study, which was conducted in Japan, included a 1- to 2-week screening period (on previous opioid) and an 8-week, open-label treatment period. …”
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    Ready Conversion of Patients with Well-Controlled, Moderate to Severe, Chronic Malignant Tumor–related Pain on Other Opioids to Tapentadol Extended Release
  13. 47813
    por Iyoda, Sunao, Manning, Shannon D., Seto, Kazuko, Kimata, Keiko, Isobe, Junko, Etoh, Yoshiki, Ichihara, Sachiko, Migita, Yuji, Ogata, Kikuyo, Honda, Mikiko, Kubota, Tsutomu, Kawano, Kimiko, Matsumoto, Kazutoshi, Kudaka, Jun, Asai, Norio, Yabata, Junko, Tominaga, Kiyoshi, Terajima, Jun, Morita-Ishihara, Tomoko, Izumiya, Hidemasa, Ogura, Yoshitoshi, Saitoh, Takehito, Iguchi, Atsushi, Kobayashi, Hideki, Hara-Kudo, Yukiko, Ohnishi, Makoto, Arai, Reiko, Kawase, Masao, Asano, Yukiko, Asoshima, Nanami, Chiba, Kazuki, Furukawa, Ichiro, Kuroki, Toshiro, Hamada, Madoka, Harada, Seiya, Hatakeyama, Takashi, Hirochi, Takashi, Sakamoto, Yumiko, Hiroi, Midori, Takashi, Kanda, Horikawa, Kazumi, Iwabuchi, Kaori, Kameyama, Mitsuhiro, Kasahara, Hitomi, Kawanishi, Shinya, Kikuchi, Koji, Ueno, Hiroyuki, Kitahashi, Tomoko, Kojima, Yuka, Konishi, Noriko, Obata, Hiromi, Kai, Akemi, Kono, Tomomi, Kurazono, Takayuki, Matsumoto, Masakado, Matsumoto, Yuko, Nagai, Yuhki, Naitoh, Hideki, Nakajima, Hiroshi, Nakamura, Hiromi, Nakane, Kunihiko, Nishi, Keiko, Saitoh, Etsuko, Satoh, Hiroaki, Takamura, Mitsuteru, Shiraki, Yutaka, Tanabe, Junichi, Tanaka, Keiko, Tokoi, Yuki, Yatsuyanagi, Jun
    Publicado 2014
    “…METHODS:  Clade typing and stx subtyping of EHEC O157:H7 strains, which were isolated in Japan during 1999–2011 from 269 HUS patients and 387 asymptomatic carriers (ACs) and showed distinct pulsed-field gel electrophoresis patterns, were performed to determine relationships between specific lineages and clinical presentation. …”
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    Phylogenetic Clades 6 and 8 of Enterohemorrhagic Escherichia coli O157:H7 With Particular stx Subtypes are More Frequently Found in Isolates From Hemolytic Uremic Syndrome Patients Than From Asymptomatic Carriers
  14. 47814
    “…Furthermore, Barssia maroccana is described from Cedrus atlantica (Morocco), Codinaea pini from Pinus patula (Uganda), Crucellisporiopsis marquesiae from Marquesia acuminata (Zambia), Dinemasporium ipomoeae from Ipomoea pes-caprae (Vietnam), Diaporthe phragmitis from Phragmites australis (China), Marasmius vladimirii from leaf litter (India), Melanconium hedericola from Hedera helix (Spain), Pluteus albotomentosus and Pluteus extremiorientalis from a mixed forest (Russia), Rachicladosporium eucalypti from Eucalyptus globulus (Ethiopia), Sistotrema epiphyllum from dead leaves of Fagus sylvatica in a forest (The Netherlands), Stagonospora chrysopyla from Scirpus microcarpus (USA) and Trichomerium dioscoreae from Dioscorea sp. (Japan). Novel species from Australia include: Corynespora endiandrae from Endiandra introrsa, Gonatophragmium triuniae from Triunia youngiana, Penicillium coccotrypicola from Archontophoenix cunninghamiana and Phytophthora moyootj from soil. …”
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    Fungal Planet description sheets: 281–319
  15. 47815
    “…METHODS: The Japanese Eculizumab Trial for GBS (JET-GBS) is a prospective, multicenter, placebo-controlled, double-blind, randomized phase II study conducted at 13 tertiary neurology centers and is funded by the Japan Agency for Medical Research and Development. …”
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    A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barré Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS)
  16. 47816
    “…The research and development approval has been obtained from Kyoto University Graduate School and Faculty of Medicine Ethics Committee, Japan, and Swaziland’s Ministry of Health Ethics and Scientific committee. …”
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    Efficacy of Mobile Serious Games in Increasing HIV Risk Perception in Swaziland: A Randomized Control Trial (SGprev Trial) Research Protocol
  17. 47817
    “…Despite the availability and widespread use of PPIs, EE complications are likely to remain a problem in Japan owing to the aging population and high-stress society.…”
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    Factors associated with complicated erosive esophagitis: A Japanese multicenter, prospective, cross-sectional study
  18. 47818
    “…METHODS: The EMBLEM trial is an ongoing, prospective, multicenter, placebo-controlled double-blind randomized, investigator-initiated clinical trial in Japan. A total of 110 participants with T2DM (HbA1c range 6.0–10.0%) and with established CVD will be randomized (1:1) to receive either empagliflozin 10 mg once daily or a placebo. …”
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    Rationale and design of a multicenter placebo-controlled double-blind randomized trial to evaluate the effect of empagliflozin on endothelial function: the EMBLEM trial
  19. 47819
    “…BACKGROUND: A fixed-dose combination of daclatasvir (DCV; hepatitis C virus NS5A inhibitor), asunaprevir (ASV; non-structural protein 3 inhibitor), and beclabuvir (BCV; non-structural protein 5B inhibitor) is approved in Japan for hepatitis C virus genotype 1. OBJECTIVE: The objective of this study was to assess the combination’s drug–drug interaction potential in vivo using a validated cocktail of eight cytochrome P450 (CYP) and transporter probes. …”
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    Effects of a Fixed-Dose Co-Formulation of Daclatasvir, Asunaprevir, and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects
  20. 47820
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    (18)F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia
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