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47961por Mantani, Akio, Kato, Tadashi, Furukawa, Toshi A, Horikoshi, Masaru, Imai, Hissei, Hiroe, Takahiro, Chino, Bun, Funayama, Tadashi, Yonemoto, Naohiro, Zhou, Qi, Kawanishi, Nao“…METHODS: A multisite, assessor-masked, parallel-group randomized controlled trial was conducted in 20 psychiatric clinics and hospitals in Japan. Participants were eligible if they had a primary diagnosis of major depression and were antidepressant-refractory after taking one or more antidepressants at an adequate dosage for four or more weeks. …”
Publicado 2017
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47962Development and validation of a duplex real-time PCR assay for the diagnosis of equine piroplasmosispor Lobanov, Vladislav A., Peckle, Maristela, Massard, Carlos L., Brad Scandrett, W., Gajadhar, Alvin A.“…This set of samples was also tested by a single-target 18S rRNA qPCR for T. equi developed at the OIE reference laboratory for EP in Japan, and a previously published single-target 18S rRNA qPCR for B. caballi whose oligonucleotides we adopted for use in the duplex qPCR. …”
Publicado 2018
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47963por Montecchiani, Celeste, Pedace, Lucia, Lo Giudice, Temistocle, Casella, Antonella, Mearini, Marzia, Gaudiello, Fabrizio, Pedroso, José L., Terracciano, Chiara, Caltagirone, Carlo, Massa, Roberto, St George-Hyslop, Peter H., Barsottini, Orlando G. P., Kawarai, Toshitaka, Orlacchio, Antonio“…Pedigrees originated in Italy, Brazil, Canada, England, Iran, and Japan. Interestingly, we identified 15 ALS5/SPG11/ KIAA1840 mutations in 12 families (two sequence variants were never reported before, p.Gln198* and p.Pro2212fs*5). …”
Publicado 2016
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47964por Mishra, Gita D., Pandeya, Nirmala, Dobson, Annette J., Chung, Hsin-Fang, Anderson, Debra, Kuh, Diana, Sandin, Sven, Giles, Graham G., Bruinsma, Fiona, Hayashi, Kunihiko, Lee, Jung Su, Mizunuma, Hideki, Cade, Janet E., Burley, Victoria, Greenwood, Darren C., Goodman, Alissa, Simonsen, Mette Kildevæld, Adami, Hans-Olov, Demakakos, Panayotes, Weiderpass, Elisabete“…STUDY DESIGN, SIZE, DURATION: This pooled study comprises 51 450 postmenopausal women from nine observational studies in the UK, Scandinavia, Australia and Japan that contribute to the International collaboration for a Life course Approach to reproductive health and Chronic disease Events (InterLACE). …”
Publicado 2017
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47965por Ishiguchi, Hiroaki, Ito, Shinji, Kato, Katsuhiko, Sakurai, Yusuke, Kawai, Hisashi, Fujita, Naotoshi, Abe, Shinji, Narita, Atsushi, Nishio, Nobuhiro, Muramatsu, Hideki, Takahashi, Yoshiyuki, Naganawa, ShinjiEnlace del recurso
Publicado 2018
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47966por Nishimoto-Kakiuchi, A, Netsu, S, Okabayashi, S, Taniguchi, K, Tanimura, H, Kato, A, Suzuki, M, Sankai, T, Konno, R“…R.K. received a consultancy fee from Chugai Pharmaceutical Co., Ltd. and lecture fees from Chugai Pharmaceuticals, Japan Vaccine Co. Ltd., Merck & Co., Mochida Co. …”
Publicado 2018
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47967por Kato, Tadashi, Furukawa, Toshi A., Mantani, Akio, Kurata, Ken’ichi, Kubouchi, Hajime, Hirota, Susumu, Sato, Hirotoshi, Sugishita, Kazuyuki, Chino, Bun, Itoh, Kahori, Ikeda, Yoshio, Shinagawa, Yoshihiro, Kondo, Masaki, Okamoto, Yasumasa, Fujita, Hirokazu, Suga, Motomu, Yasumoto, Shingo, Tsujino, Naohisa, Inoue, Takeshi, Fujise, Noboru, Akechi, Tatsuo, Yamada, Mitsuhiko, Shimodera, Shinji, Watanabe, Norio, Inagaki, Masatoshi, Miki, Kazuhira, Ogawa, Yusuke, Takeshima, Nozomi, Hayasaka, Yu, Tajika, Aran, Shinohara, Kiyomi, Yonemoto, Naohiro, Tanaka, Shiro, Zhou, Qi, Guyatt, Gordon H.“…RESULTS: Between December 2010 and March 2015, we recruited 2011 participants with hitherto untreated major depression at 48 clinics in Japan. In step 1, 970 participants were allocated to the 50 mg/day and 1041 to the 100 mg/day arms; 1927 (95.8%) provided primary outcomes. …”
Publicado 2018
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47968por Parmegiani, L., Beilby, K. H., Arnone, A., Bernardi, S., Maccarini, A. M., Nardi, E., Cognigni, G. E., Filicori, M.“…Each patient’s embryos were first randomized for vitrification with two different kits: Vitrification Kit (Kitazato, Japan) and Sage Vitrification Kit (Origio, Denmark). …”
Publicado 2018
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47969por Yang, Jae Jeong, Yu, Danxia, Wen, Wanqing, Saito, Eiko, Rahman, Shafiur, Shu, Xiao-Ou, Chen, Yu, Gupta, Prakash C., Gu, Dongfeng, Tsugane, Shoichiro, Xiang, Yong-Bing, Gao, Yu-Tang, Yuan, Jian-Min, Tamakoshi, Akiko, Irie, Fujiko, Sadakane, Atsuko, Tomata, Yasutake, Kanemura, Seiki, Tsuji, Ichiro, Matsuo, Keitaro, Nagata, Chisato, Chen, Chien-Jen, Koh, Woon-Puay, Shin, Myung-Hee, Park, Sue K., Wu, Pei-Ei, Qiao, You-Lin, Pednekar, Mangesh S., He, Jiang, Sawada, Norie, Li, Hong-Lan, Gao, Jing, Cai, Hui, Wang, Renwei, Sairenchi, Toshimi, Grant, Eric, Sugawara, Yumi, Zhang, Shu, Ito, Hidemi, Wada, Keiko, Shen, Chen-Yang, Pan, Wen-Harn, Ahn, Yoon-Ok, You, San-Lin, Fan, Jin-Hu, Yoo, Keun-Young, Ashan, Habibul, Chia, Kee Seng, Boffetta, Paolo, Inoue, Manami, Kang, Daehee, Potter, John D., Zheng, Wei“…A total of 1 002 551 Asian individuals (from mainland China, Japan, South Korea, Singapore, Taiwan, India, and Bangladesh) were followed up for more than 3 years. …”
Publicado 2019
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47970por Murray, Jennifer M, French, David P, Patterson, Christopher C, Kee, Frank, Gough, Aisling, Tang, Jianjun, Hunter, Ruth F“…METHODS: Physical activity was assessed at baseline and 6 months using pedometers (Yamax Digiwalker CW-701, Japan). Markers of engagement and website use, monitoring system use, and reward redemption were collected throughout the scheme. …”
Publicado 2019
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47971por Tran, Cam Tuan, Felber Medlin, Loyse, Lama, Nicola, Taranu, Brindusa, Ng, Weeteck, Haziza, Christelle, Picavet, Patrick, Baker, Gizelle, Lüdicke, Frank“…METHODS: This multiregional (United States, Japan, and Europe), multicenter (42 sites) cohort study consisting of a 1-year SA period in an ambulatory setting was conducted from May 2015 to May 2017. …”
Publicado 2019
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47972por Yoshikawa, Takaki, Muro, Kei, Shitara, Kohei, Oh, Do-Youn, Kang, Yoon-Koo, Chung, Hyun Cheol, Kudo, Toshihiro, Chin, Keisho, Kadowaki, Shigenori, Hamamoto, Yasuo, Hironaka, Shuichi, Yoshida, Kazuhiro, Yen, Chia-Jui, Omuro, Yasushi, Bai, Li-Yuan, Maeda, Kaijiro, Ozeki, Akichika, Yoshikawa, Reigetsu, Kitagawa, Yuko“…DESIGN, SETTING, AND PARTICIPANTS: This phase 2, double-blind randomized clinical trial (RAINSTORM [First-line S-1 Plus Oxaliplatin With or Without Ramucirumab Followed by Paclitaxel Plus Ramucirumab in Patients With Advanced Gastric Cancer]) was conducted from October 12, 2015, to April 11, 2018, at 36 sites in Japan, South Korea, and Taiwan. Participants were chemotherapy-naive patients (n = 189) with metastatic gastric or gastroesophageal adenocarcinoma. …”
Publicado 2019
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47973por Chandramouli, Chanchal, Tay, Wan Ting, Bamadhaj, Nurul Sahiddah, Tromp, Jasper, Teng, Tiew-Hwa Katherine, Yap, Jonathan J. L., MacDonald, Michael R., Hung, Chung-Lieh, Streng, Koen, Naik, Ajay, Wander, Gurpreet Singh, Sawhney, Jitendra, Ling, Lieng Hsi, Richards, A. Mark, Anand, Inder, Voors, Adriaan A., Lam, Carolyn S. P.“…METHODS AND FINDINGS: Utilising the Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry (11 Asian regions including Taiwan, Hong Kong, China, India, Malaysia, Thailand, Singapore, Indonesia, Philippines, Japan, and Korea; 46 centres with enrolment between 1 October 2012 and 6 October 2016), we prospectively examined 5,964 patients with symptomatic HF (mean age 61.3 ± 13.3 years, 26% women, mean BMI 25.3 ± 5.3 kg/m(2), 16% with HF with preserved ejection fraction [HFpEF; ejection fraction ≥ 50%]), among whom 2,051 also had waist-to-height ratio (WHtR) measurements (mean age 60.8 ± 12.9 years, 24% women, mean BMI 25.0 ± 5.2 kg/m(2), 7% HFpEF). …”
Publicado 2019
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47974por Toriyama, Kazuhiro, Tajika, Masahiro, Tanaka, Tsutomu, Ishihara, Makoto, Hirayama, Yutaka, Onishi, Sachiyo, Mizuno, Nobumasa, Kuwahara, Takamichi, Okuno, Nozomi, Matsumoto, Shinpei, Sasaki, Eiichi, Abe, Tetsuya, Yatabe, Yasushi, Hara, Kazuo, Matsuo, Keitaro, Tamaki, Tsuneo, Niwa, Yasumasa“…The invasion depth of ESCC was classified according to the Japan Esophageal Society. Primary endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial ESCC. …”
Publicado 2019
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47975por Worm, Margitta, Simpson, Eric L., Thaçi, Diamant, Bissonnette, Robert, Lacour, Jean-Philippe, Beissert, Stefan, Kawashima, Makoto, Ferrándiz, Carlos, Smith, Catherine H., Beck, Lisa A., Chan, Kuo-Chen, Chen, Zhen, Akinlade, Bolanle, Hultsch, Thomas, Staudinger, Heribert, Gadkari, Abhijit, Eckert, Laurent, Davis, John D., Rajadhyaksha, Manoj, Graham, Neil M. H., Pirozzi, Gianluca, Stahl, Neil, Yancopoulos, George D., Ardeleanu, Marius“…DESIGN, SETTING, AND PARTICIPANTS: The Study to Confirm the Efficacy and Safety of Different Dupilumab Dose Regimens in Adults With Atopic Dermatitis (LIBERTY AD SOLO-CONTINUE) was a randomized, double-blind, phase 3 clinical trial conducted from March 25, 2015, to October 18, 2016, at 185 sites in North America, Europe, Asia, and Japan. Patients with moderate to severe AD who received dupilumab treatment and achieved an Investigator’s Global Assessment score of 0 or 1 or 75% improvement in Eczema Area and Severity Index scores (EASI-75) at week 16 in 2 previous dupilumab monotherapy trials (LIBERTY AD SOLO 1 and 2) were rerandomized in SOLO-CONTINUE. …”
Publicado 2019
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47976por Zhu, Dongshan, Chung, Hsin-Fang, Dobson, Annette J, Pandeya, Nirmala, Giles, Graham G, Bruinsma, Fiona, Brunner, Eric J, Kuh, Diana, Hardy, Rebecca, Avis, Nancy E, Gold, Ellen B, Derby, Carol A, Matthews, Karen A, Cade, Janet E, Greenwood, Darren C, Demakakos, Panayotes, Brown, Daniel E, Sievert, Lynnette L, Anderson, Debra, Hayashi, Kunihiko, Lee, Jung Su, Mizunuma, Hideki, Tillin, Therese, Simonsen, Mette Kildevæld, Adami, Hans-Olov, Weiderpass, Elisabete, Mishra, Gita D“…METHODS: We harmonised and pooled individual-level data from 15 observational studies done across five countries and regions (Australia, Scandinavia, the USA, Japan, and the UK) between 1946 and 2013. Women who had reported their menopause status, age at natural menopause (if postmenopausal), and cardiovascular disease status (including coronary heart disease and stroke) were included. …”
Publicado 2019
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47977por Wen, Pengfei, Zhang, Yumin, Hao, Linjie, Yue, Ju’an, Wang, Jun, Wang, Tao, Song, Wei, Guo, Wanshou, Ma, Tao“…Subsequently, five categories of osteonecrosis FE models were established by using the normal model and computer software according to China-Japan Friendship Hospital (CJFH) classification for ONFH. …”
Publicado 2020
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47978por Silverberg, Jonathan I., Simpson, Eric L., Thyssen, Jacob P., Gooderham, Melinda, Chan, Gary, Feeney, Claire, Biswas, Pinaki, Valdez, Hernan, DiBonaventura, Marco, Nduaka, Chudy, Rojo, Ricardo“…Patients were enrolled from 115 centers in Australia, Bulgaria, Canada, China, Czechia, Germany, Hungary, Japan, South Korea, Latvia, Poland, United Kingdom, and the United States from June 29, 2018, to August 13, 2019. …”
Publicado 2020
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47979por Kalaeva, Elena, Kalaev, Vladislav, Chernitskiy, Anton, Alhamed, Mohammad, Safonov, Vladimir“…MATERIALS AND METHODS: The content of potassium (K), sodium (Na), iron (Fe), Copper (Cu), Zinc (Zn), Strontium (Sr), arsenic (As), nickel (Ni), cobalt (Co), chromium (Cr), molybdenum (Mo), and selenium (Se) in the blood serum of 33 pregnant cows between 239 and 262 days of gestation and their 33 1-day old calves was determined using the Shimadzu AA6300 (Japan) atomic adsorption spectrophotometer. Calcium (Ca) and magnesium (Mg) content was determined using ion-selective electrodes from the Olympus-400 analyzer (Beckman Coulter, USA). …”
Publicado 2020
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47980por Nakase, Junsuke, Shimozaki, Kengo, Yoshimizu, Rikuto, Tsuchiya, Hiroyuki, Asai, Kazuki“…For both the supine and upright examinations, we used a special MRI apparatus (Gravity MRI, Hitachi, Japan) that is capable of imaging in any position with a static magnetic field strength of 0.4 T (Figure). …”
Publicado 2020
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