“…In 1970, John Maynard Smith published a letter, entitled “Natural Selection and the Concept of a Protein Space,” that proposed a simple analogy for the incremental process of adaptive evolution. …”
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“…I extend the current scholarly focus from the nineteenth to the twentieth century by providing a microhistory of the early popular writings of evolutionary biologist John Maynard Smith (1920–2004). Linking them to the state of evolutionary biology as a professional science as well as Maynard Smith’s own professional standing, I examine the interplay between author, text and audiences. …”
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“…Few analogies have been as successful in communicating the basics of molecular evolution as John Maynard Smith’s protein space analogy (1970), in which he compared protein evolution to the transition between the terms WORD and GENE, changing one letter at a time to yield a different, meaningful word (in his example, the preferred path was WORD → WORE → GORE → GONE → GENE). …”
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“…First, there is the approach of evolutionary game theory, which was introduced in 1973 by John Maynard Smith and George R. Price. In this theory, the dynamical process of natural selection is not modeled explicitly. …”
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“…John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. …”
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“…To facilitate visual analysis of sequencing data, the software produces three-dimensional scatter plots similar in concept to Sewall Wright and John Maynard Smith’s adaptive or fitness landscape. The software also contains functions that are particularly useful for doped selections such as mutation frequency analysis, information content calculation, multivariate statistical functions (including principal component analysis), sequence distance metrics, sequence searches and sequence comparisons across multiple Illumina data sets. …”
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“…Over four decades ago, John Maynard Smith showed that a mutation causing asexual reproduction should rapidly spread in a dioecious sexual population. …”
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