Mostrando 41 - 60 Resultados de 122 Para Buscar '"KLC"', tiempo de consulta: 0.10s Limitar resultados
  1. 41
    “…The light chains (KLCs) of the heterotetrameric microtubule motor kinesin-1, that bind to cargo adaptor proteins and regulate its activity, have a capacity to recognize short peptides via their tetratricopeptide repeat domains (KLC(TPR)). Here, using X-ray crystallography, we show how kinesin-1 recognizes a novel class of adaptor motifs that we call ‘Y-acidic’ (tyrosine flanked by acidic residues), in a KLC-isoform specific manner. …”
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    Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors
  2. 42
    “…Lemur tyrosine kinase-2 (LMTK2) is a binding partner for p35 and here we show that LMTK2 also interacts with kinesin-1 light chains (KLC1/2). Binding to KLC1/2 involves a C-terminal tryptophan/aspartate (WD) motif in LMTK2 and the tetratricopeptide repeat (TPR) domains in KLC1/2, and this interaction facilitates axonal transport of LMTK2. …”
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    LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains
  3. 43
    “…The KHC also binds to the kinesin light chain (KLC), which has been implicated in both autoinhibition and activation of the motor. …”
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    Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity
  4. 44
    “…Kinesin1 plays a major role in neuronal transport by recruiting many different cargos through its kinesin light chain (KLC). Various structurally unrelated cargos interact with the conserved tetratricopeptide repeat (TPR) domain of KLC. …”
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    Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain
  5. 45
    “…We first analyzed the genome structure of KLC and its genomic relationship with other chickens and observed unique characteristics. …”
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    The idiosyncratic genome of Korean long-tailed chicken as a valuable genetic resource
  6. 46
    “…Furthermore, co-expression of LINC00152 and KLC2 was observed in human HCC cohorts and high KLC2 expression was associated with shorter patient survival. …”
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    LINC00152 Drives a Competing Endogenous RNA Network in Human Hepatocellular Carcinoma
  7. 47
    “…F12 and KLC share similar size, pI, hydropathy and cargo-binding tetratricopeptide repeats (TPRs). …”
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    Vaccinia Protein F12 Has Structural Similarity to Kinesin Light Chain and Contains a Motor Binding Motif Required for Virion Export
  8. 48
    “…Several cargos associate with Kinesin via Kinesin light chain (KLC). However, KLC is not required for all Kinesin transport. …”
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    The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline
  9. 49
    “…Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis. …”
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    Variability in the kinesin light chain 1 gene may influence risk of age-related cataract
  10. 50
    “…Biochemical and genetic evidence demonstrate that kinesin recruitment and mitochondrial transport are independent of kinesin light chain (KLC); KLC antagonizes milton's association with KHC and is absent from milton–KHC complexes, and mitochondria are present in klc (−/−) photoreceptor axons. …”
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    Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent
  11. 51
    “…Alcadeinα (Alcα; also called Calsyntenin-1) is an evolutionarily conserved type I single-pass transmembrane protein that binds to kinesin-1 light chain (KLC) to activate kinesin-1's transport of Alcα-containing vesicles. …”
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    Constitutive Cleavage of the Single-Pass Transmembrane Protein Alcadeinα Prevents Aberrant Peripheral Retention of Kinesin-1
  12. 52
    “…Keratosis lichenoides chronica (KLC) is a rare dermatosis which represents different clinical characteristics between adult‐ and pediatric‐onset cases. …”
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    Childhood‐onset keratosis lichenoides chronica: A case report
  13. 53
    “…PURPOSE: To study whether presenilin 1 (PSEN1), apolipoprotein E (APOE), and kinesin light chain 1 (KLC1) genotypes are associated with the risk of developing age-related cortical cataracts in the Han Chinese population. …”
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    The link between apolipoprotein E, presenilin 1, and kinesin light chain 1 gene polymorphisms and age-related cortical cataracts in the Chinese population
  14. 54
    “…We found that phosphorylation of three serine residues in the acidic region located between the two WD motifs is required for interaction with KLC. Phosphorylation of these serine residues may alter the disordered structure of the acidic region to induce direct association with KLC. …”
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    Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo
  15. 55
    “…The increased CRMP2 phosphorylation correlated with decreased CRMP2 binding to Drp1, Miro 2, and KLC1. (S)-LCM rescued CRMP2 binding to Drp1 and Miro 2 but not to KLC1. …”
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    CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons
  16. 56
    “…In addition, we detected up-regulation of kinesin light chain 1 (KLC1) and its increased association with dynein but reduced microtubule-associated KLC1 in the Loa samples. …”
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    Neurodegenerative Mutation in Cytoplasmic Dynein Alters Its Organization and Dynein-Dynactin and Dynein-Kinesin Interactions
  17. 57
    “…Various genomic islands, PAPI-1, PAPI-2, PAGI-1, PAGI-2, PAGI-3, and PAGI-4, and the element pKLC102 have been characterized in different P. aeruginosa strains from diverse habitats and geographical locations. …”
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    Genetic and Phenotypic Characterization of a Pseudomonas aeruginosa Population with High Frequency of Genomic Islands
  18. 58
    “…Western blot and q-PCR analysis showed the presence of specific keratinocyte markers including cytokeratin-5, involucrin, filaggrin and stratifin in these keratinocyte-like cells (KLC); these markers were absent in ASC. To further evaluate if KLC were capable of stratification akin to human keratinocytes, ASC were seeded on top of human decellularized dermis and cultured in the presence or absence of EGF and high Ca(2+) concentrations. …”
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    Transdifferentiation of Adipose-Derived Stem Cells into Keratinocyte-Like Cells: Engineering a Stratified Epidermis
  19. 59
    por Zehir, Sinan, Alic, Taner
    Publicado 2023
    “…No significant correlation was determined between the BMI values and the VAS and KLC values (P > .05). No significant correlation was determined between the total corrected angular and the preoperative and postoperative pain, and clinical and functional knee scores (VAS, AKSFS, CAKSS, TFAS) (P > .05). …”
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    The effects on joint functions of biplanar distal tubercle open-wedge high tibial osteotomy: A prospective study
  20. 60
    “…In addition, in the inactive state, the KHC motor domains are pushed apart by the KLC subunit. Thus, FRET stoichiometry reveals conformational changes of a protein complex in live cells. …”
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    Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells
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