Mostrando 1 - 20 Resultados de 122 Para Buscar '"KLC"', tiempo de consulta: 0.47s Limitar resultados
  1. 1
    “…KlcA shows anti-methylation only during transformation. …”
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    Functional comparison of anti-restriction and anti-methylation activities of ArdA, KlcA, and KlcA(HS) from Klebsiella pneumoniae
  2. 2
    “…BACKGROUND: KLC3 protein as a member of the kinesin light-chain protein family plays an important role in spermatogenesis, during formation of mitochondrial sheath in the mid piece of the sperm tail. …”
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    Altered expression of KLC3 may affect semen parameters
  3. 3
    “…Among the 13 genes, the variant frequencies of protein kinase C epsilon (PRKCE) (c.240T>C, 35.9% vs 47.7%, P < 0.05) and kinesin light chain 1 (KLC1) (c.216A>G, 2.9% vs 98.1%, P< 0.01) were significantly lower in psoriasis than in normal Asian individuals. …”
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    Variants in PRKCE and KLC1, Potential Regulators of Type I Psoriasis
  4. 4
    “…These findings suggest that the anti-restriction protein, KlcA(HS), represents a novel mechanism that facilitates the increased transfer of bla(KPC-2) and KlcA(HS)-carrying plasmids among K. pneumoniae strains.…”
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    Anti-Restriction Protein, KlcA(HS), Promotes Dissemination of Carbapenem Resistance
  5. 5
    por Hu, Wanqi, Tu, Zhijian Jake
    Publicado 2018
    “…Further analysis confirmed the expression of the endogenous KLC2 in the testes, which was not detected in the previous RNA sequencing data. …”
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    Functional analysis of the promoter of an early zygotic gene KLC2 in Aedes aegypti
  6. 6
    “…The culture of AT-MSCs induced typical keratinocyte morphology and up-regulatedthe expression of cytokeratin-14, Involucrin, and P63 compared to AT-MSCs cultured on theplastic surface (P < 0.05). Besides, KLC sheets were generated once slight changes occur in theenvironment temperature. …”
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    The Combined Thermoresponsive Cell-Imprinted Substrate, Induced Differentiation, and "KLC Sheet" Formation
  7. 7
    “…Using live imaging approaches in klc4 mutant zebrafish, we show that KLC4 is required for stabilization of nascent axon branches, proper microtubule (MT) dynamics, and endosomal transport. …”
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    KLC4 shapes axon arbors during development and mediates adult behavior
  8. 8
    “…We created a humanized Caenorhabditis elegans model in which klc-2 was replaced by human KLC4 (referred to as hKLC4) and assessed the extent to which hKLC4 retained function in the worm. …”
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    A humanized Caenorhabditis elegans model of hereditary spastic paraplegia-associated variants in KLC4
  9. 9
    “…Lack of KLC1 did not inhibit phagosome speed, but run length was decreased, and phagosome localization and degradation were impaired. …”
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    Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis
  10. 10
    “…The kinesin-1 light chain (KLC) mediates cargo binding and regulates kinesin-1 motility. …”
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    Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3
  11. 11
    “…Here, we demonstrate that a complex containing RNA and the RNA-binding protein (RBP) SFPQ interacts selectively with a tetrameric kinesin containing the adaptor KLC1 and the motor KIF5A. We show that the binding of SFPQ to the KIF5A/KLC1 motor complex is required for axon survival and is impacted by KIF5A mutations that cause Charcot-Marie Tooth (CMT) disease. …”
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    Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival
  12. 12
    “…Previously, we showed that EFV requires conventional interaction between the JIP1b C-terminal region and the kinesin light chain 1 (KLC1) tetratricopeptide repeat, whereas EHF requires a novel interaction between the central region of JIP1b and the coiled-coil domain of KLC1. …”
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    Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1
  13. 13
    “…Here, we report the case of a KLC1–ALK-rearranged NSCLC patient responding to crizotinib treatment and demonstrate how analysis of plasma and serum biomarkers can be used to identify the ALK fusion partner and monitor therapy over time. …”
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    Serial liquid biopsies for detection of treatment failure and profiling of resistance mechanisms in KLC1–ALK-rearranged lung cancer
  14. 14
    “…We created a humanized C. elegans model where klc-2 was replaced with human KLC4 and assessed the extent to which hKLC4 retained function in the worm. …”
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    A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4
  15. 15
    “…In contrast, the epithelial differentiation factor and EMT suppressor prolactin (PRL) was found to repress KIF5B gene expression and KIF5B-Snail1 nuclear accumulation, but enhanced KLC1 gene expression and KIF5B-KLC1 interaction. …”
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    A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis
  16. 16
    “…To the best of our knowledge, KLC1-ALK is the first novel oncogenic fusion identified using only FFPE tissues. …”
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    KLC1-ALK: A Novel Fusion in Lung Cancer Identified Using a Formalin-Fixed Paraffin-Embedded Tissue Only
  17. 17
    “…Here, we calculated inbreeding levels using a runs of homozygosity approach, mutation age and local ancestry to infer the origin of each chromosomal segments containing disorder-causing mutations in KLC2, IMPA1, MED25 and WNT7A. Genotyped data were generated from 18 patients affected by AR diseases and combined to the 1000 genome project (1KGP) and Simons genome diversity project (SGDP) databases to infer local ancestry. …”
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    Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations
  18. 18
    “…The aim of this study was to show the frequency of the pilS2 gene, and its association with P. aeruginosa plasmid pKLC102 and PAPI-1 pathogenicity island among P. aeruginosa strains. …”
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    Molecular characterization of the pilS2 gene and its association with the frequency of Pseudomonas aeruginosa plasmid pKLC102 and PAPI-1 pathogenicity island
  19. 19
    “…In this article, we characterize ArdB anti-restriction proteins and their close homologues, the KlcA proteins from a range of mobile genetic elements; including an ArdB encoded on a pathogenicity island from uropathogenic Escherichia coli and a KlcA from an IncP-1b plasmid, pBP136 isolated from Bordetella pertussis. …”
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    The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro
  20. 20
    “…CONCLUSION: These data point to significant reductions in KLC1 in AD and AD-DS. In so doing, they raise the possibility of compromised KLC1-mediated axonal transport in these conditions, a posit that can now be pursued in model systems in which KLC1 expression is reduced. …”
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    Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport
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