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222Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapypor Bigliardi, Paul Lorenz, Rout, Bhimsen, Pant, Aakanksha, Krishnan-Kutty, Viknish, Eberle, Alex N., Srinivas, Ramasamy, Burkett, Brendan Adrian, Bigliardi-Qi, Mei“…A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially effective adjuvant therapeutic method to control benign skin hyperpigmentation or superficial melanotic malignancy such as Lentigo Maligna Melanoma (LMM).…”
Publicado 2017
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223
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224por Magalotti, D, Citraro, S, Donati, S, Luciano, P, Piendibene, M, Giannetti, P, Lanza, A, Verzellesi, G, Sakellariou, Andreas, Billereau, W, Combe, J M“…As the experiment complexity, accelerator backgrounds, and instantaneous luminosity increase, more effective and accurate data selection techniques are needed. The Fast TracKer processor (FTK) is a real time tracking processor designed for the ATLAS trigger upgrade. …”
Publicado 2013
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225OG716: Designing a fit-for-purpose lantibiotic for the treatment of Clostridium difficile infectionspor Kers, Johan A., DeFusco, Anthony W., Park, Jae H., Xu, Jin, Pulse, Mark E., Weiss, William J., Handfield, MartinEnlace del recurso
Publicado 2018
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226por Fischer, Carol L., Bates, Amber M., Lanzel, Emily A., Guthmiller, Janet M., Johnson, Georgia K., Singh, Neeraj Kumar, Kumar, Ansu, Vidva, Robinson, Abbasi, Taher, Vali, Shireen, Xie, Xian Jin, Zeng, Erliang, Brogden, Kim A.“…Predicted and observed chemokine and cytokine responses of GE KER + DC + HTL exposed to LPS and Pam3CSK4 matched 75% (15/20, p = 0.02069) and 80% (16/20, P = 0.005909), respectively. …”
Publicado 2019
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227por Andreani, A, Annovi, A, Beccherle, B, Beretta, M, Citterio, M, Crescioli, F, Colombo, A, Giannetti, P, Liberali, V, Shojaii, J, Stabile, A“…The 4th generation of AMchip has been developed for the core pattern recognition stage of the Fast TracKer (FTK) processor: a hardware processor for online reconstruction of particle trajectories at the ATLAS experiment at LHC. …”
Publicado 2013
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228por Iizawa, T“…The Fast TracKer (FTK) will perform global track reconstruction after each Level-1 trigger accept signal to enable the software-based higher level trigger to have early access to tracking information. …”
Publicado 2014
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229por Alison, J, Boevia, A, Bogdan, M, Bryant, P, Cheng, YY, Krizka, K, Shochet, M, Tompkins, L, Webster, J“…The ATLAS Fast TracKer is a hardware-based track finder for the ATLAS High Level Trigger. …”
Publicado 2014
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230
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231
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232por Andreani, A, Annovi, A, Beccherle, R, Beretta, M, Citterio, M, Crescioli, F, Colombo, A, Giannetti, P, Liberali, V, Shojaii, S, Stabile, A“…The 4th generation of AMchip has been developed for the core pattern\nrecognition stage of the Fast TracKer (FTK) processor: a hardware processor for online reconstruction\nof particle trajectories at the ATLAS experiment at LHC. …”
Publicado 2013
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233por Okumura, Y, Liu, T, Olsen, J, Iizawa, T, Mitani, T, Korikawa, T, Yorita, K, Annovi, A, Beretta, M, Gatta, M, Sotiropoulou, C, Gkaitatzis, S, Kordas, K, Kimura, N, Cremonesi, M, Yin, H, Xu, Z“…The first stage of the ATLAS Fast TracKer (FTK) is an ATCA-based input interface system, where hits from the entire silicon tracker must be clustered and organized into overlapping eta-phi trigger towers before being sent to the tracking processors. …”
Publicado 2014
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234por Okumura, Yasuyuki, Liu, Tiehui Ted, Olsen, Jamieson, Iizawa, Tomoya, Mitani, Takashi, Korikawa, Tomohiro, Yorita, Kohei, Annovi, Alberto, Beretta, Matteo, Gatta, Maurizio, Sotiropoulou, C-L., Gkaitatzis, Stamatios, Kordas, Konstantinos, Kimura, Naoki, Cremonesi, Matteo, Yin, Hang, Xu, Zijun“…The first stage of the ATLAS Fast TracKer (FTK) is an ATCA-based input interface system, where hits from the entire silicon tracker are clustered and organized into overlapping eta-phi trigger towers before being sent to the tracking engines. …”
Publicado 2014
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235por Holmes, Tova Ray“…Though hardware-based trackers were a crucial element of the triggering systems for both D0 and CDF, no such system has yet been incorporated into either ATLAS or CMS. The ATLAS FastTracKer (FTK) is a first step towards this goal, and will soon provide full tracking information for all events passing ATLAS’s Level-1 trigger. …”
Publicado 2018
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236por Zhang, J“…The design and studies of the performance for the ATLAS hardware Fast TracKer (FTK) are presented. The existing trigger system of the ATLAS experiment is deployed to reduce the event rate from the bunch crossing rate of 40 MHz to < 1 KHz for permanent storage at the LHC design luminosity of 10^34 cm^-2 s^-1. …”
Publicado 2014
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237por van Bilsen, Jolanda H. M., Sienkiewicz-Szłapka, Edyta, Lozano-Ojalvo, Daniel, Willemsen, Linette E. M., Antunes, Celia M., Molina, Elena, Smit, Joost J., Wróblewska, Barbara, Wichers, Harry J., Knol, Edward F., Ladics, Gregory S., Pieters, Raymond H. H., Denery-Papini, Sandra, Vissers, Yvonne M., Bavaro, Simona L., Larré, Colette, Verhoeckx, Kitty C. M., Roggen, Erwin L.“…The proposed AOP will be shared at the www.aopwiki.org platform to expand the mechanistic data, improve the confidence in each of the proposed KE and key event relations (KERs), and allow for the identification of new, or refinement of established KE and KERs.…”
Publicado 2017
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238“…The AOPs were developed using a fundamental understanding of the developmental biology of the organs of interest, paying close attention to the gestational timing of key events (KEs) to very specifically inform the domain of life stage applicability for the key event relationships (KERs). Chemical stressor data primarily from studies on low molecular weight phthalates (LMWPs) served to ‘bound’ the pathways of focus in this dynamic period of development and were integrated with the developmental biology data through an iterative process to define KEs and conclude on the extent of evidence in support of the KERs. …”
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