Mostrando 961 - 980 Resultados de 358,120 Para Buscar '"Key"', tiempo de consulta: 1.66s Limitar resultados
  1. 961
  2. 962
    por Huber, Margit A, Kraut, Norbert
    Publicado 2015
    “…Here, we highlight some of the key discoveries bringing precision oncology to cancer patients. …”
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  3. 963
    “…Autophagy is a process preserving the balance between synthesis, degradation and recycling of cellular components and is therefore essential for neuronal survival and function. Several key proteins govern the autophagy pathway including beclin1 and microtubule associated protein 1 light chain 3 (LC3). …”
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  4. 964
    “…Protein content and gene expression of key hepatic gluconeogenic molecules were measured: cytosolic and mitochondrial phosphoenolpyruvate carboxykinase (PEPCK‐C and PEPCK‐M), glucose‐6‐phosphatase‐alpha (G6Pase‐α), G6Pase‐β, fructose‐1,6‐bisphosphatase (FBPase), and forkhead box‐O1 (FOXO1). …”
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  5. 965
    por Toma-Dasu, Iuliana, Dasu, Alexandru
    Publicado 2015
    “…Combining multiparameter information from imaging with predictive information from biopsies and molecular analyses as well as in treatment monitoring of tumour responsiveness appears to be the key approach to maximise the individualisation of treatment. …”
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  6. 966
  7. 967
    por Kawade, Kensuke, Tanimoto, Hirokazu
    Publicado 2014
    “…Signaling molecules move between cells to form a characteristic distribution pattern within a developing organ; thereafter, they spatiotemporally regulate organ development. A key question in this process is how the signaling molecules robustly form the precise distribution on a tissue scale in a reproducible manner. …”
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  8. 968
  9. 969
  10. 970
    “…We previously determined two key parameters that underlie the target DNA preference for prototype foamy virus (PFV) and human immunodeficiency virus type 1 (HIV-1) integration: flexible pyrimidine (Y)/purine (R) dinucleotide steps at the centers of the integration sites, and base contacts with specific integrase residues, such as Ala188 in PFV integrase and Ser119 in HIV-1 integrase. …”
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  11. 971
    “…Transforming growth factor-β (TGF-β) signaling is a key regulator of ECM secretion and assembly in multiple tissues, including the anterior segment of the eye, and it has been linked to KC. …”
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  12. 972
  13. 973
  14. 974
  15. 975
    “…This review focuses on the positive aspects of DNA vaccines for prostate cancer that have been assessed in preclinical and clinical trials thus far and examines the key considerations that must be employed to improve the efficacy and immunogenicity of these vaccines.…”
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  16. 976
  17. 977
    por Hayes, Ann
    Publicado 2015
    “…Drug discovery productivity has failed to improve markedly in recent years and a key issue is high attrition due to efficacy failures in initial proof-of concept clinical studies. …”
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  18. 978
  19. 979
  20. 980
    por Wang, Jia, Liu, Shuai, Fu, Weina
    Publicado 2014
    “…So in this paper, we analyzed the relation between the affinity and sequence structure of core DNA, and extracted the set of key positions. In these positions, the nucleotide sequences probably occupy mainly action in the binding. …”
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