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  1. 2761
    “…The findings were integrated into a prior functional knowledge base from Gene Ontology, interaction networks, Kyoto Encyclopedia of Genes and Genomes pathways, sequence motif analysis, and literature molecular concepts. …”
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    Genomewide Analysis of Aryl Hydrocarbon Receptor Binding Targets Reveals an Extensive Array of Gene Clusters that Control Morphogenetic and Developmental Programs
  2. 2762
    “…Contact: Yoshihiro.Yamanishi@ensmp.fr Supplementary information: Datasets and all prediction results are available at http://web.kuicr.kyoto-u.ac.jp/supp/yoshi/drugtarget/.…”
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    Prediction of drug–target interaction networks from the integration of chemical and genomic spaces
  3. 2763
    “…Our findings suggest that a host of inflammation and extracellular matrix remodelling pathways are upregulated within the aorta in mice developing aneurysms. Kyoto Encyclopedia of Genes and Genome categories enriched in the aortas of mice with aneurysms included cytokine-cytokine receptor interaction, leukocyte transendothelial migration, natural killer cell mediated cytotoxicity and hematopoietic cell lineage. …”
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    Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm
  4. 2764
    “…BACKGROUND: We previously demonstrated remarkable differences in the expression of IL-8/CXCL8 in aortic tissues and vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) compared to VSMC from normotensive Wistar-Kyoto rats (WKY). In the present study, we investigated the direct effect of IL-8/CXCL8 on expression of 12-lipoxygenase (LO), a hypertensive modulator, in SHR VSMC. …”
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    IL-8/CXCL8 Upregulates 12-Lipoxygenase Expression in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats
  5. 2765
    “…METHODS: Cells were exposed to neutron beams in the presence of boronophenylalanine (BPA) at Kyoto University Research Reactor. Treated cells were monitored for modulations in colony formation, proliferation, cell cycle, and expression of cell cycle-associated proteins. …”
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    Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma
  6. 2766
    “…METHODS: The performance of male Brown Norway, Lewis, Fischer 344, and Wistar Kyoto rats in open field (OF), elevated plus-maze (EPM), and circular light-dark preference box (cLDB) tasks, which are believed to provide measures of emotional reactivity, was evaluated. …”
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    Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains
  7. 2767
    “…METHODS: We reviewed all of the cases of lung cancer from January 1999 to July 2007 in the Department of Respiratory Medicine, Kyoto University Hospital, Japan. Thirteen patients with metastatic spinal tumor of lung cancer underwent surgery, and all of them had a poor performance status score (3 or 4). …”
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    Outcome of Surgical Treatment for Metastatic Vertebra Bone Tumor in Advanced Lung Cancer
  8. 2768
    “…Availability: RactIP is implemented in C++, and the source code is available at http://www.ncrna.org/software/ractip/ Contact: ykato@kuicr.kyoto-u.ac.jp; satoken@k.u-tokyo.ac.jp Supplementary information: Supplementary data are available at Bioinformatics online.…”
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    RactIP: fast and accurate prediction of RNA-RNA interaction using integer programming
  9. 2769
    “…This representation would help to discover, for example, novel functions of a transcription factor that regulates genes on a metabolic pathway. Pathway maps of the Kyoto Encyclopedia of Genes and Genomes (KEGG) and maps generated from their gene classifications are available at KaPPA-View4 KEGG version (http://kpv.kazusa.or.jp/kpv4-kegg/). …”
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    KaPPA-View4: a metabolic pathway database for representation and analysis of correlation networks of gene co-expression and metabolite co-accumulation and omics data
  10. 2770
    “…Therefore, we assessed its properties in cellular (endothelial cells [EC], and vascular smooth muscle cells [VSMC]) and animal models (Wistar Kyoto rats and c57Bl/6 mice) of angiogenesis. RESULTS: In EC, but not VSMC, RGDechiHCit inhibits intracellular mitogenic signaling and cell proliferation. …”
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    Evaluation of the anti-angiogenic properties of the new selective α(V)β(3 )integrin antagonist RGDechiHCit
  11. 2771
    “…Another 8 age-matched male Wistar–Kyoto rats were used as normotensive group (WKY). …”
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    The antihypertensive effect of ethyl acetate extract from red raspberry fruit in hypertensive rats
  12. 2772
    “…These 242 genes were submitted to bioinformatic analysis using a total of nine tools to detect enrichment of Gene Ontology (GO) categories or Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. …”
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    Systematic enrichment analysis of gene expression profiling studies identifies consensus pathways implicated in colorectal cancer development
  13. 2773
    “…We used up to ten tools for overrepresentation analysis of Gene Ontology (GO) categories or Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in each of the three gene lists (1475, 124 and 54 genes). …”
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    Consensus Pathways Implicated in Prognosis of Colorectal Cancer Identified Through Systematic Enrichment Analysis of Gene Expression Profiling Studies
  14. 2774
    “…To physically confirm Mcs6 and Mcs2, congenic lines were established using the Wistar-Furth (WF) rat strain, which is susceptible to developing mammary carcinomas, as the recipient (genetic background) and either Wistar-Kyoto (WKy, Mcs6) or Copenhagen (COP, Mcs2), which are resistant, as donor strains. …”
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    Physical Confirmation and Mapping of Overlapping Rat Mammary Carcinoma Susceptibility QTLs, Mcs2 and Mcs6
  15. 2775
    “…The endogenously depressed rat and its control strain were developed by bidirectional selective breeding from the Wistar–Kyoto (WKY) rat, an accepted model of major depressive disorder (MDD). …”
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    Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models
  16. 2776
    “…KEYWORDS: hypoxia-inducible factor (HIF), hypoxia-response element (HRE), transcription factor (TF), transcription factor binding site (TFBS), KEGG (Kyoto Encyclopedia of Genes and Genomes), cross-species comparison, orthology, paralogy, functional pathway…”
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    Functional pathway mapping analysis for hypoxia-inducible factors
  17. 2777
    “…Only nephrons with glomerular collapse (n = 13) showed tubules with reduced diameter indicating atrophy [21.66 ± 2.56 μm vs. tubules in normotensive Wistar Kyoto rats (WKY) 38.56 ± 0.56 μm, p < 0.05], as well as afferent arteriolar wall hypertrophy (diameter 32.74 ± 4.72 μm vs. afferent arterioles in WKY 19.24 ± 0.98 μm, p < 0.05). …”
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    Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats
  18. 2778
    “…An i.p. injection of danshen at 10 mg kg(−1) significantly lowered systolic blood pressure (SBP) of spontaneously hypertensive rats (SHRs) but failed to modify the SBP in normotensive Wistar-Kyoto rats (WKY). Oral administration of tanshinone IIA also decreased SBP in SHR but not in WKY. …”
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    Antihypertension Induced by Tanshinone IIA Isolated from the Roots of Salvia miltiorrhiza
  19. 2779
    “…We first conducted the BCC GWAS among 1,797 BCC cases and 5,197 controls in Caucasians with 740,760 genotyped SNPs. 115,688 SNPs were grouped into gene transcripts within 20 kb in distance and then into 174 Kyoto Encyclopedia of Genes and Genomes pathways, 205 BioCarta pathways, as well as two positive control gene sets (pigmentation gene set and BCC risk gene set). …”
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    Pathway Analysis for Genome-Wide Association Study of Basal Cell Carcinoma of the Skin
  20. 2780
    “…Assembled sequences were annotated with Gene Ontology, Gene Family and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. …”
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    Gene discovery using next-generation pyrosequencing to develop ESTs for Phalaenopsis orchids
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