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3221por Kida, Teruyo, Flammer, Josef, Oku, Hidehiro, Konieczka, Katarzyna, Morishita, Seita, Horie, Taeko, Ikeda, Tsunehiko“…In addition, immunoreactivity to ET-A receptor was higher in SHR retinas than in control (WKY; Wistar Kyoto rat) retinas (Fig. 2). The protein levels of ET-A receptor and HIF-1 were also significantly higher in SHR retinas than in WKY retinas (Fig. 3). …”
Publicado 2018
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3222“…Furthermore, a protein-protein interaction network was identified. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses based on the human database was conducted to obtain signaling pathway and correlation prediction analyses of overall human clock and clock-controlled gene correlations. …”
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3223“…Gene Ontology (GO) analysis showed that in addition to basic cellular functions such as gene transcription, cell differentiation, and cell migration, other biological processes such as steroidogenesis, cell signaling and angiogenesis were also enriched in up-regulated genes; by comparison, some processes were down-regulated including piRNA metabolism, gene silencing and proteolysis. Further Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis identified a variety of signaling pathways that might play pivotal roles in PG-PV transition, including MAPK, TGF-β, Hedgehog, FoxO, VEGF, Jak-STAT, and phosphatidylinositol signaling pathways. …”
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3224por Lin, Peng, Zhong, Xiao-Zhu, Wang, Xiao-Dong, Li, Jian-Jun, Zhao, Rui-Qi, He, Yu, Jiang, Yan-Qiu, Huang, Xian-Wen, Chen, Gang, He, Yun, Yang, Hong“…Bioinformatics tools were applied using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO). …”
Publicado 2018
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3225por Geng, Rong-Xin, Li, Ning, Xu, Yang, Liu, Jun-hui, Yuan, Fan-en, Sun, Qian, Liu, Bao-Hui, Chen, Qian-Xue“…Then, gene ontology (GO) analysis as well as Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were carried out using the Database for Annotation, Visualization and Integrated Discovery (DAVID). …”
Publicado 2018
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3226por Yoshimura, Akihiro, Uchino, Junji, Tanimura, Keiko, Chihara, Yusuke, Tamiya, Nobuyo, Kaneko, Yoshiko, Takeda, Takayuki, Hiranuma, Osamu, Hasegawa, Isao, Kubota, Yutaka, Shiotsu, Shinsuke, Takumi, Chieko, Hiraoka, Noriya, Yamada, Tadaaki, Takayama, Koichi“…The protocol was approved by the institutional review boards of Kyoto Prefectural University of Medicine and all the participating hospitals. …”
Publicado 2018
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3227por Sun, Ruixia, Zhang, Wenwen, Zhong, Hua, Wang, Lamei, Tang, Na, Liu, Yongmin, Zhao, Yongli, Zhang, Tian, He, Fang“…In this study, we treated SHR and Wistar-Kyoto rats with R568 for 8 weeks. The tail-cuff method was used to assess rat BP weekly. …”
Publicado 2018
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3228“…To test this hypothesis, we investigated whether the acetylcholine-induced endothelium dependent relaxation (ACh-EDR) of mesenteric arteries (MA) are altered by gemigliptin pretreatment in Spontaneous Hypertensive Rats (SHR) and in Wistar-Kyoto rats (WKY) under hyperglycemia-like conditions (HG; 2 hr incubation with 50 mM glucose). …”
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3229por Zhang, Qian, Xiao, Xinhua, Zheng, Jia, Li, Ming, Yu, Miao, Ping, Fan, Wang, Tong, Wang, Xiaojing“…A gene array showed that CDDP changed 262 genes significantly in the diabetic retina. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that differentially expressed genes in the CDDP-treated groups were involved mainly in the apoptosis pathway. …”
Publicado 2018
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3230por Lin, Yu-Te, Wu, Yi-Chung, Sun, Gwo-Ching, Ho, Chiu-Yi, Wong, Tzyy-Yue, Lin, Ching-Huang, Chen, Hsin-Hung, Yeh, Tung-Chen, Li, Chia-Jung, Tseng, Ching-Jiunn, Cheng, Pei-Wen“…Here, we aimed to determine whether reactive oxygen species (ROS) reduction by resveratrol in the brain leads to cognitive impairment reduction in rats with angiotensin II (Ang-II)-induced early AD. Male Wistar Kyoto (WKY) rats with Ang-II-induced AD were treated with losartan or resveratrol for two weeks. …”
Publicado 2018
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3231“…Gene ontology term analysis showed that the DEGs in the B‐ and C‐inbred triads were enriched for metabolic process, cellular process cell part, binding, and catalytic activity. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis indicated that the DEGs in the B‐ and C‐inbred triads were involved in focal adhesion, the P13K‐Akt signaling pathway, the mRNA surveillance pathway, and the focal adhesion pathway. …”
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3232“…GO (gene ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis of 326 overlapping genes between DMGs and DEGs showed obvious enrichment in terms related to metabolic disorders and immune responses. …”
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3233por Tang, Yue-Ting, Huang, Yi-Yao, Li, Jing-Huan, Qin, Si-Hua, Xu, Yong, An, Tai-Xue, Liu, Chun-Chen, Wang, Qian, Zheng, Lei“…RESULTS: The small RNA profile of exosomes was altered following EMT. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the specific miRNAs of M-exosomes have the potential to drive signal transduction networks in EMT and cancer progression. …”
Publicado 2018
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3234por Pérez de Frutos, Javier, Hofstad, Erlend F., Solberg, Ole Vegard, Tangen, Geir Arne, Lindseth, Frank, Langø, Thomas, Elle, Ole Jakob, Mårvik, Ronald“…METHODS: The Single Landmark method is compared to fiducial landmark on an IOUSFAN (Kyoto Kagaku Co., Ltd., Japan) soft tissue abdominal phantom and T2 magnetic resonance scans of it. …”
Publicado 2018
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3235“…RESULTS: A total of 7130 lncRNAs and 9867 mRNAs were differentially expressed among normal skin, scar, and MU tissues. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrated that these aberrantly expressed transcripts were mainly involved in cell cycle, immune response, and the p53 signaling pathway. …”
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3236por Griffiths, Philip R., Lolait, Stephen J., Pearce, Louise E., McBryde, Fiona D., Paton, Julian F. R., O’Carroll, Anne-Marie“…Apelin expression is increased in the rostral ventrolateral medulla (RVLM) in spontaneously hypertensive rats (SHRs) compared to Wistar-Kyoto (WKY) normotensive rats, however, evidence that the apelinergic system chronically influences mean arterial blood pressure (MABP) under pathophysiological conditions remains to be established. …”
Publicado 2018
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3237“…GEO2R tool was used to screen out differentially expressed genes (DEGs) between OCCC tumor and normal ovary tissue. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed using the g:Profiler database and Cytoscape. …”
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3238por Zhang, Xiaoxue, Shang, Jin, Wang, Xiaoyang, Cheng, Genyang, Jiang, Yumin, Liu, Dong, Xiao, Jing, Zhao, Zhanzheng“…Microarray and bioinformatics analysis gave an overview of the features of differentially expressed genes. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis demonstrated the typical biological alterations in DN. …”
Publicado 2018
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3239por Zeng, Digang, Chen, Xiuli, Peng, Jinxia, Yang, Chunling, Peng, Min, Zhu, Weilin, Xie, Daxiang, He, Pingping, Wei, Pinyuan, Lin, Yong, Zhao, Yongzhen, Chen, Xiaohan“…We successfully annotated 81.72% of all unique SMRT transcripts against the NCBI non-redundant database, 58.63% against Swiss-Prot, 45.38% against Gene Ontology, 32.57% against Clusters of Orthologous Groups of proteins (COG), and 47.83% against Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. …”
Publicado 2018
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3240por Kim, Bo-Mi, Kang, Seunghyun, Kim, Ryeo-Ok, Jung, Jee-Hyun, Lee, Kyun-Woo, Rhee, Jae-Sung, Lee, Young-Mi“…Functional gene annotations were performed using Gene Ontology, Eukaryotic Orthologous Groups, and Kyoto Encyclopedia of Genes and Genomes pathway analyses. …”
Publicado 2018
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