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41por Umezawa, Akihiro, Sato, Yoji, Kusakawa, Shinji, Amagase, Rin, Akutsu, Hidenori, Nakamura, Kazuaki, Kasahara, Mureo, Matsubara, Yoichi, Igarashi, Takashi“…Two groups from Kyoto University and the National Center for Child Health and Development (NCCHD) established a novel derivation/cultivation system of ESCs for potential application in translational and clinical research. …”
Publicado 2020
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42“…The emphasis is on the scaling radial sector FFA type: A collaboration work is ongoing in view of better understanding the properties of the 150 MeV scaling FFA at Kyoto University Institute for Integrated Radiation and Nuclear Science in Japan and progress toward high-intensity operation. …”
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43por Ikeda, Hanako Ohashi, Sasaoka, Norio, Koike, Masaaki, Nakano, Noriko, Muraoka, Yuki, Toda, Yoshinobu, Fuchigami, Tomohiro, Shudo, Toshiyuki, Iwata, Ayana, Hori, Seiji, Yoshimura, Nagahisa, Kakizuka, Akira“…Here we describe small compounds (Kyoto University Substances, KUSs) that were developed to inhibit the ATPase activity of VCP (valosin-containing protein), the most abundant soluble ATPase in the cell. …”
Publicado 2014
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44por Toi, Masakazu, Pillai, M. Radhakrishna, Gupta, Sudeep, Badwe, Rajendra, Carmo-Fonseca, Maria, Costa, Luis, Chow, Louis WC, Knapp, Stefan, Kumar, Rakesh“…This year's symposium was co-organized by the Organization for Oncology and Translational Research (OOTR) at the Shiran Hall, Kyoto University, Kyoto, Japan, from November 14 and 15, 2014. …”
Publicado 2015
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45por Nakano, Noriko, Ikeda, Hanako Ohashi, Hasegawa, Tomoko, Muraoka, Yuki, Iwai, Sachiko, Tsuruyama, Tatsuaki, Nakano, Masaki, Fuchigami, Tomohiro, Shudo, Toshiyuki, Kakizuka, Akira, Yoshimura, Nagahisa“…We have recently succeeded in synthesizing novel compounds, KUSs (Kyoto University Substances), which can reduce cellular ATP consumption by specifically inhibiting the ATPase activities of VCP, a major ATPase in the cell, and we have shown that KUSs could mitigate the disease progression of rd10, a mouse model of retinitis pigmentosa, without any apparent side effects. …”
Publicado 2016
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46por Hasegawa, Tomoko, Muraoka, Yuki, Ikeda, Hanako Ohashi, Tsuruyama, Tatsuaki, Kondo, Mineo, Terasaki, Hiroko, Kakizuka, Akira, Yoshimura, Nagahisa“…We have shown that valosin-containing protein (VCP) modulators, Kyoto University Substances (KUSs), ameliorated abnormally low ATP levels by inhibiting the ATPase of VCP, thereby protected several types of cells, including retinal neurons, from cell death-inducing insults. …”
Publicado 2016
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47por Hata, Masayuki, Ikeda, Hanako O., Kikkawa, Chinami, Iwai, Sachiko, Muraoka, Yuki, Hasegawa, Tomoko, Kakizuka, Akira, Yoshimura, Nagahisa“…We previously synthesized Kyoto University substances (KUSs) as modulators of valosin-containing protein (VCP); KUSs inhibit VCP ATPase activity and protect cells from different cell death-inducing insults. …”
Publicado 2017
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48Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritispor Nakagawa, Shunsaku, Nakaishi, Mayumi, Hashimoto, Motomu, Ito, Hiromu, Yamamoto, Wataru, Nakashima, Ran, Tanaka, Masao, Fujii, Takao, Omura, Tomohiro, Imai, Satoshi, Nakagawa, Takayuki, Yonezawa, Atsushi, Imai, Hirohisa, Mimori, Tsuneyo, Matsubara, Kazuo“…Patients were enrolled from the Kyoto University RA Management Alliance cohort, and followed up prospectively for 12 months. …”
Publicado 2018
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49por Okada, Kazuyuki, Nishigori, Tatsuto, Obama, Kazutaka, Tsunoda, Shigeru, Hida, Koya, Hisamori, Shigeo, Sakai, Yoshiharu“…METHODS: Consecutive patients with gastric cancer who underwent curative gastrectomy between June 2006 and August 2017 at the Kyoto University Hospital were included in this retrospective study. …”
Publicado 2019
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50por Tsurubuchi, Takao, Shirakawa, Makoto, Kurosawa, Wataru, Matsumoto, Kayo, Ubagai, Risa, Umishio, Hiroshi, Suga, Yasuyo, Yamazaki, Junko, Arakawa, Akihiro, Maruyama, Yutaka, Seki, Takuya, Shibui, Yusuke, Yoshida, Fumiyo, Zaboronok, Alexander, Suzuki, Minoru, Sakurai, Yoshinori, Tanaka, Hiroki, Nakai, Kei, Ishikawa, Eiichi, Matsumura, Akira“…The effectiveness of BNCT using MMT1242 was assessed in animal irradiation studies at the Kyoto University Research Reactor. MMT1242 showed a high uptake and broad intracellular distribution in vitro, longer tumor retention compared to BSH and BPA, and adequate tumor-to-normal tissue accumulation ratio and low toxicity in vivo. …”
Publicado 2020
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51por Takeuchi, Koji, Hattori, Yoshihide, Kawabata, Shinji, Futamura, Gen, Hiramatsu, Ryo, Wanibuchi, Masahiko, Tanaka, Hiroki, Masunaga, Shin-ichiro, Ono, Koji, Miyatake, Shin-Ichi, Kirihata, Mitsunori“…Based on these results, neutron irradiation was evaluated at the Kyoto University Research Reactor Institute (KURRI) with KA-BSH. …”
Publicado 2020
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52por Komatsu, Teruya, Chen-Yoshikawa, Toyofumi F., Ikeda, Masaki, Takahashi, Koji, Nishimura, Akiko, Harashima, Shin-ichi, Date, Hiroshi“…PATIENTS AND METHODS: Data of individuals who underwent pulmonary resection for NSCLC from 2000 to 2015 were extracted from the database of Kyoto University Hospital. The primary endpoint was the incidence of postoperative complications, and secondary endpoints were postoperative length of hospital stay and overall survival. …”
Publicado 2020
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53por Furukawa, Keiko, Makino, Yasuhide, Mineharu, Yohei, Umeda, Katsutsugu, Takita, Junko, Arakawa, Yoshiki“…In the study, the clinical data and surgical specimen are collected into the National Center for Child Health. Kyoto University Hospital has participated in the study since IRB approval in 2011. …”
Publicado 2020
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54“…In this study, clinical data and surgical specimen are collected into the National Center for Child Health. Kyoto University Hospital has participated in this study since IRB approval in 2011. …”
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55por Hartuti, Endah Dwi, Sakura, Takaya, Tagod, Mohammed S. O., Yoshida, Eri, Wang, Xinying, Mochizuki, Kota, Acharjee, Rajib, Matsuo, Yuichi, Tokumasu, Fuyuki, Mori, Mihoko, Waluyo, Danang, Shiomi, Kazuro, Nozaki, Tomoyoshi, Hamano, Shinjiro, Shiba, Tomoo, Kita, Kiyoshi, Inaoka, Daniel Ken“…In this study, we screened 40,400 compounds from the Kyoto University chemical library against recombinant PfDHODH. …”
Publicado 2021
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56por Hamada, Miho, Takeda, Chikashi, Dong, Li, Hirotsu, Akiko, Shizuya, Izumi, Mizota, Toshiyuki“…Methods: This study included 816 patients undergoing laparoscopic gynecological surgery under general anesthesia at Kyoto University Hospital between 2012 and 2018. The primary exposure was the use of fentanyl-based ivPCA. …”
Publicado 2022
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57por Ogimoto, Tatsuya, Ozasa, Hiroaki, Yoshida, Hironori, Nomizo, Takashi, Funazo, Tomoko, Yoshida, Hiroshi, Hashimoto, Kentaro, Hosoya, Kazutaka, Yamazoe, Masatoshi, Ajimizu, Hitomi, Tsuji, Takahiro, Sakamori, Yuichi, Kuninaga, Kiyomitsu, Morita, Satoshi, Hirai, Toyohiro“…The CD47 SNP genotypes and clinical outcomes were retrospectively analyzed in 164 patients with NSCLC treated with nivolumab at Kyoto University Hospital (Kyoto, Japan). Patients with the G/G genotype of the CD47 SNP rs3804639 had significantly longer progression-free survival than those with the G/T or T/T genotypes [2.6 months vs. 2.1 months, hazard ratio (HR), 0.70; P=0.026]. …”
Publicado 2023
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58por Hu, Naonori, Suzuki, Minoru, Masunaga, Shin-ichiro, Kashino, Genro, Kinashi, Yuko, Chen, Yi-Wen, Liu, Yong, Uehara, Koki, Mitsumoto, Toshinori, Tanaka, Hiroki, Ono, Koji“…However, there are various challenges that arise when installing a reactor in a hospital environment. From 2006, the Kyoto University Research Reactor Institute, in collaboration with Sumitomo Heavy Industries, began the development of an accelerator-based neutron source for clinical BNCT in a bid to overcome the shortcomings of a nuclear reactor-based neutron source. …”
Publicado 2023
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59por Kiba, Takayoshi, Inamoto, Takashi, Nishimura, Tsutomu, Ueno, Masaya, Yanagihara, Kazuhiro, Teramukai, Satoshi, Kato, Hironori, Toi, Masakazu, Fukushima, Masanori“…METHODS: This study investigated the assessment of variables in defining prognosis of 742 breast cancer women with pathological stage (pTNM) I-III diagnosed between 1980 and 2005 at the Kyoto University Hospital in Japan, by age, clinical stage (cTNM), pTNM, the numbers of positive lymph nodes (pN), and ER status. …”
Publicado 2008
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60por Fujita, Yusei, Kato, Itsuro, Iwai, Soichi, Ono, Koji, Suzuki, Minoru, Sakurai, Yoshinori, Ohnishi, Ken, Ohnishi, Takeo, Yura, Yoshiaki“…METHODS: Cells were exposed to neutron beams in the presence of boronophenylalanine (BPA) at Kyoto University Research Reactor. Treated cells were monitored for modulations in colony formation, proliferation, cell cycle, and expression of cell cycle-associated proteins. …”
Publicado 2009
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