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221por Thomé, Sabrina, Lessa-Aquino, Carolina, Ko, Albert Icksang, Lilenbaum, Walter, Medeiros, Marco Alberto“…The data were analyzed and ROC curves were generated. Altogether, LigB [131-649aa] L. interrogans Canicola, LigB [131-649aa] L. kirschneri Gryppotyphosa and LipL32 L. interrogans Copenhageni showed best accuracy (AUC = 0.826 to 0.869), with 70% specificity and sensitivity ranging from 89% to 95%. …”
Publicado 2014
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222por Leite de Marcelos, Priscylla Gonçalves Correia, Perez, Danyel Elias da Cruz Perez, Soares, Diego Moura, de Araújo, Samuel Silva, Evêncio, Liriane Baratella, Pontual, Maria Luiza dos Anjos, Ramos-Perez, Flávia Maria de Moraes“…Three groups were treated with ZOL (0.15 mg/kg/week, intraperitoneal), and 3 with 0.9% saline solution (controls). In the ZOL/Lig30 and ZOL/Lig 15 groups, after 4 weeks of treatment with ZOL, EP was induced and euthanasia was performed after 30 and 15 days of EP induction, respectively. …”
Publicado 2021
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223por Santos, N. F., Rodrigues, J., Pereira, S. O., Fernandes, A. J. S., Monteiro, T., Costa, F. M.“…Still, other materials can be combined with LIG to provide added functionalities and enhanced performance. …”
Publicado 2021
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224por Tang, Xialing, Xie, Shanshan, Wang, Huajun, Li, Yingbin, Lai, Zhiyu, Sun, Shuangxi, Pan, Ruanhuan, Huang, Yan, Cai, Jun“…Our previous study found that the combination of Astragalus membranaceus extract and ligustrazine (Ast+Lig) treatment could protect brain tissues against inflammation in rats with thrombolytic cerebral ischemia. …”
Publicado 2022
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225por Brzostek, Anna, Szulc, Izabela, Klink, Magdalena, Brzezinska, Marta, Sulowska, Zofia, Dziadek, Jaroslaw“…To this end, we constructed Mtb strains defective for HR (ΔrecA), NHEJ [Δ(ku,ligD)], or both DSB repair systems [Δ(ku,ligD,recA)]. …”
Publicado 2014
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226por Liu, Shufen, Zhao, Bizeng, Shi, Huipeng, Liang, Qianqian, Fu, Yishan, Yang, Zhu, Xu, Leqin, Wang, Yongjun, Bian, Qin“…CEP hypertrophy is one of the characteristics of intervertebral disc degeneration (IDD). LIG exerts a protective effect on IDD in animal model. …”
Publicado 2016
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227por Zheng, Qun, Huang, Yue-yue, Zhu, Peng-chong, Tong, Qiang, Bao, Xiao-yi, Zhang, Qi-hao, Zheng, Guo-qing, Wang, Yan“…Ligustrazine (Lig) is one of the main effective components of Ligusticum Chuanxiong Hort, which possesses a variety of biological activities in the cardiovascular system. …”
Publicado 2018
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228por Liao, Jianjun, Zhang, Xiangya, Sun, Zihan, Chen, Hande, Fu, Jian, Si, Hewei, Ge, Chengjun, Lin, Shiwei“…Owing to the unique advantages of LIG technique, including facile fabrication, mass production, and versatile, more physiological signals (glucose, uric acid, tyrosine, etc.) could be easily expanded into the LIG-based wearable sensors to reflect the health status or clinical needs of individuals.…”
Publicado 2022
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229“…BACKGROUND: ATM; XRCC6 and LIG4 genes play an important role in repairing the double-strand DNA breaks and maintaining the genome stability. …”
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230“…In this paper, a portable three-electrode sensor based on laser-induced graphene (LIG) was proposed for the electrochemical detection of CBZ. …”
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231“…The effects of laser processing parameters, laser type, precursor materials, and process atmosphere on the properties of the prepared LIG were reviewed. Then, two strategies for large-scale production of LIG were briefly described. …”
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232por Vaughan, Robert M., Kupai, Ariana, Foley, Caroline A., Sagum, Cari A., Tibben, Bailey M., Eden, Hope E., Tiedemann, Rochelle L., Berryhill, Christine A., Patel, Varun, Shaw, Kevin M., Krajewski, Krzysztof, Strahl, Brian D., Bedford, Mark T., Frye, Stephen V., Dickson, Bradley M., Rothbart, Scott B.“…We show that the UHRF1 TTD binds LIG1K126me2 with high affinity and selectivity compared to other known methyllysine readers. …”
Publicado 2020
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233por Caracciolo, Daniele, Juli, Giada, Riillo, Caterina, Coricello, Adriana, Vasile, Francesca, Pollastri, Sara, Rocca, Roberta, Scionti, Francesca, Polerà, Nicoletta, Grillone, Katia, Arbitrio, Mariamena, Staropoli, Nicoletta, Caparello, Basilio, Britti, Domenico, Loprete, Giovanni, Costa, Giosuè, Di Martino, Maria Teresa, Alcaro, Stefano, Tagliaferri, Pierosandro, Tassone, Pierfrancesco“…Based on the three-dimensional (3D) LIG3 structure, we performed a computational screening to identify LIG3-targeting natural compounds as potential candidates to counteract Alt-NHEJ activity in MM. …”
Publicado 2022
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234por Barnett, Robert L., Austermann, Jacqueline, Dyer, Blake, Telfer, Matt W., Barlow, Natasha L. M., Boulton, Sarah J., Carr, Andrew S., Creel, Roger C.“…Polar temperatures during the Last Interglacial [LIG; ~129 to 116 thousand years (ka)] were warmer than today, making this time period an important testing ground to better understand how ice sheets respond to warming. …”
Publicado 2023
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235“…We used mice with a hypomorphic mutation in DNA ligase IV (Lig4(Y288C)), ataxia telangiectasia mutated (Atm(−)(/−)) and double mutant Atm(−)(/−)/Lig4(Y288C) mice. …”
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236por Larentis, Ariane Leites, Nicolau, Júlia Fabiana Monteiro Quintal, Esteves, Gabriela dos Santos, Vareschini, Daniel Tait, de Almeida, Fernanda Vicente Ribeiro, dos Reis, Mitermayer Galvão, Galler, Ricardo, Medeiros, Marco Alberto“…The expression of LigB (131-645aa) was associated with cell growth. …”
Publicado 2014
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237“…Six reaction products of Zn(II) and Ni(II) with pyridine-2,6-dicarboxylic acid (H(2)Lig(1)), 4-chloropyridine-2,6-dicarboxylic acid (H(2)Lig(2)) and 4-hydroxypyridine-2,6-dicarboxylic acid (H(2)Lig(3)) are used to pinpoint the structural consequences of crystal field stabilization by an incomplete d shell. …”
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238por Kim, Chanwoo, Hwang, Eunseung, Kwon, Jinhyeong, Jang, Tae Hwan, Lee, Won Chul, Kim, Shi Hyeong, Park, Jongmin, Lee, Ming‐Tsang, Kim, Hyun, Hong, Sukjoon, Lee, Habeom“…Laser‐Induced Graphene One of the keys to utility of laser‐induced graphene (LIG) is the ability to manufacture designed macroscopic geometries in a high‐throughput manner. …”
Publicado 2023
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239por Lamazares, Emilio, MacLeod-Carey, Desmond, Miranda, Fernando P., Mena-Ulecia, Karel“…Our results from docking, molecular dynamics simulation, molecular mechanics Poisson–Boltzmann (MM-PBSA) method, ligand efficiency, and ADME-Tox properties (Absorption, Distribution, Metabolism, Excretion, and Toxicity) indicate that the designed ligands were adequately oriented in the thermolysin active site. The Lig783, Lig2177, and Lig3444 compounds showed the best dynamic behavior; however, from the ADME-Tox calculated properties, Lig783 was selected as the unique antibacterial agent candidate amongst the designed ligands.…”
Publicado 2021
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240por Hristovski, Ilija R., Herman, Luke A., Mitchell, Michael E., Lesack, Nikolai I., Reich, Jason, Holzman, Jonathan F.“…It is hoped that these findings will lay a foundation for the application of LIG in future integrated technologies.…”
Publicado 2022
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