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181por Mehta, Akash M., Jordanova, Ekaterina S., Kenter, Gemma G., Ferrone, Soldano, Fleuren, Gert- Jan“…A tissue microarray containing carcinoma lesions from 109 cervical carcinoma patients was stained for HLA class I heavy chains, β(2)-microglobulin, LMP2, LMP7, LMP10, TAP1, TAP2, ERAP1, tapasin, calreticulin, calnexin and ERp57. …”
Publicado 2007
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182Publicado 1996“…Further analysis of Ad12- transformed cells revealed that the expression of both LMP2 and LMP7, but not of other proteasome complex components, was downregulated, resulting in altered proteolytic activities of the 20S proteasomes. …”
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183por Subklewe, Marion, Paludan, Casper, Tsang, Ming L., Mahnke, Karsten, Steinman, Ralph M., Münz, Christian“…Part of this EBV-specific CD8(+) T cell response, in both lytic and interferon γ secretion assays, was specific for the EBV nuclear antigen (EBNA)3A and latent membrane protein (LMP)2 latency antigens that are known to be expressed at low levels in transformed cells. …”
Publicado 2001
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184por Gatto, Graziana, Rossi, Annalisa, Rossi, Daniela, Kroening, Sven, Bonatti, Stefano, Mallardo, Massimo“…We report that miR-155 expression is much higher in EBV-immortalized B cells than in EBV-negative B cells. LMP1, but not LMP2, up-regulated the expression of miR-155, when transfected in EBV-negative B cells. …”
Publicado 2008
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185por Imadome, Ken-Ichi, Yajima, Misako, Arai, Ayako, Nakazawa, Atsuko, Kawano, Fuyuko, Ichikawa, Sayumi, Shimizu, Norio, Yamamoto, Naoki, Morio, Tomohiro, Ohga, Shouichi, Nakamura, Hiroyuki, Ito, Mamoru, Miura, Osamu, Komano, Jun, Fujiwara, Shigeyoshi“…Expression of the EBV nuclear antigen 1 (EBNA1), the latent membrane protein 1 (LMP1), and LMP2, but not EBNA2, in the engrafted cells is consistent with the latency II program of EBV gene expression known in CAEBV. …”
Publicado 2011
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186por Maldonado, Marcela, Kapphahn, Rebecca J., Terluk, Marcia R., Heuss, Neal D., Yuan, Ching, Gregerson, Dale S., Ferrington, Deborah A.“…The current study tests whether the Classical or Alternative Pathways are regulated by immunoproteasome following chronic TNFα exposure in cultured retinal pigment epithelial cells isolated from wild-type mice and mice deficient in one (LMP2, L2) or two (LMP7 and MECL-1, L7M1) immunoproteasome subunits. …”
Publicado 2013
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187por Chia, Whay-Kuang, Teo, Marissa, Wang, Who-Whong, Lee, Bernett, Ang, Soo-Fan, Tai, Wai-Meng, Chee, Chit-Lai, Ng, Joanna, Kan, Rebecca, Lim, Wan-Teck, Tan, Sze-Huey, Ong, Whee-Sze, Cheung, Yin-Bun, Tan, Eng-Huat, Connolly, John E, Gottschalk, Stephen, Toh, Han-Chong“…Infusion of CTL products containing T cells specific for LMP2 positively correlated with OS (hazard ratio: 0.35; 95% confidence interval: 0.14–0.84; P = 0.014). …”
Publicado 2014
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188por Vlková, Veronika, Štěpánek, Ivan, Hrušková, Veronika, Šenigl, Filip, Mayerová, Veronika, Šrámek, Martin, Šímová, Jana, Bieblová, Jana, Indrová, Marie, Hejhal, Tomáš, Dérian, Nicolas, Klatzmann, David, Six, Adrien, Reiniš, Milan“…In this study we documented association of DNA demethylation of selected antigen-presenting machinery genes located in the MHC genomic locus (TAP-1, TAP-2, LMP-2, LMP-7) upon IFNγ treatment with MHC class I upregulation on tumour cells in several MHC class I-deficient murine tumour cell lines (TC-1/A9, TRAMP-C2, MK16 and MC15). …”
Publicado 2014
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189por Mehta, Akash M., Spaans, Vivian M., Mahendra, Nyoman Bayu, Osse, Elisabeth M., Vet, Jessica N. I., Purwoto, Gatot, Surya, I. G. D., Cornian, Santoso, Peters, Alexander A., Fleuren, Gert J., Jordanova, Ekaterina S.“…Eleven non-synonymous, coding SNPs in the TAP1, TAP2, LMP2, LMP7 and ERAP1 genes were genotyped in cervical carcinoma patients and healthy controls from two distinct Indonesian populations (Balinese and Javanese). …”
Publicado 2015
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190por Schuld, Nathan J., Hussong, Stacy A., Kapphahn, Rebecca J., Lehmann, Ute, Roehrich, Heidi, Rageh, Abrar A., Heuss, Neal D., Bratten, Wendy, Gregerson, Dale S., Ferrington, Deborah A.“…Retinas or retinal pigment epithelial (RPE) cells from wild type (WT) and knockout (KO) mice lacking either one (LMP2) or two (LMP7 and MECL-1) catalytic subunits of the immunoproteasome were utilized in this study. …”
Publicado 2015
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191por Thuring, Camilla, Follin, Elna, Geironson, Linda, Freyhult, Eva, Junghans, Victoria, Harndahl, Mikkel, Buus, Søren, Paulsson, Kajsa M“…Some APM components, for example, TAP1/TAP2 and LMP2/LMP7, showed variable but coordinated expression, whereas ERAP1/ERAP2 displayed an imbalanced expression pattern. …”
Publicado 2015
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192“…Some T-cell epitope sequences in EBNA1 and LMP2A genes showed extensive variation across strains, which implied their importance in the development of vaccines and T-cell therapy. …”
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193por Oh, In Soo, Textoris-Taube, Kathrin, Sung, Pil Soo, Kang, Wonseok, Gorny, Xenia, Kähne, Thilo, Hong, Seon-Hui, Choi, Young Joon, Cammann, Clemens, Naumann, Michael, Kim, Jong Hoon, Park, Su-Hyung, Yoo, Ook Joon, Kloetzel, Peter M, Seifert, Ulrike, Shin, Eui-Cheol“…We found that, although IFN-γ induced the transcriptional expression of mRNAs encoding the β1i/LMP2, β2i/MECL-1 and β5i/LMP7 immunoproteasome subunits, the formation of immunoproteasomes was significantly suppressed in HCV-infected cells. …”
Publicado 2016
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194por Namba-Fukuyo, Hiroe, Funata, Sayaka, Matsusaka, Keisuke, Fukuyo, Masaki, Rahmutulla, Bahityar, Mano, Yasunobu, Fukayama, Masashi, Aburatani, Hiroyuki, Kaneda, Atsushi“…TET2 was found to be downregulated by EBV transcripts, e.g. BARF0 and LMP2A, and also by seven human miRNAs targeting TET2, e.g., miR-93 and miR-29a, which were upregulated by EBV infection, and transfection of which into gastric cells repressed TET2. …”
Publicado 2016
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195por Sethumadhavan, Shalini, Silva, Murillo, Philbrook, Phaethon, Nguyen, Thao, Hatfield, Stephen M., Ohta, Akio, Sitkovsky, Michail V.“…Corroborating oxygen-dependent regulation of MHC antigen presentation, hyperoxia (60% oxygen) transcriptionally upregulated MHC expression and increased levels of TAP2, LMP2 and 7. In conclusion, this study reveals a novel mechanism by which intra-tumoral hypoxia and HIF can potentiate immune escape. …”
Publicado 2017
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196por Lee, Hwan Hee, Lee, Seulki, Shin, Yu Su, Cho, Miyeon, Kang, Hyojeung, Cho, Hyosun“…Interestingly, quercetin inhibited EBV viral protein expressions, including EBNA-1 and LMP-2 proteins in tumor tissues from mice injected with EBV(+) human gastric carcinoma. …”
Publicado 2016
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197por Nagel, Stefan, Uphoff, Cord C., Dirks, Wilhelm G., Pommerenke, Claudia, Meyer, Corinna, Drexler, Hans G.“…We showed that the EBV-encoded factors LMP1 and LMP2A activated the expression of HLX via STAT3. …”
Publicado 2019
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198por Palma-Lara, Icela, Sánchez-Aldana, Ana Elena, Jiménez-Hernández, Elva, Martínez-Villegas, Octavio, Núñez-Enríquez, Juan Carlos, Mejía-Aranguré, Juan Manuel, Ochoa, Sara A., Xicohtencatl-Cortes, Juan, Cruz-Córdova, Ariadnna, Zavala-Vega, Sergio, García-Jiménez, Mariana, Contreras-Ramos, Alejandra, Torres-Nava, José Refugio, Mora-Ramiro, Guillermo, Arellano-Galindo, José“…Their expression can be modified by activation of NOTCH1, induced by the Epstein–Barr (EBV) viral proteins identified as LMP1 and LMP2. To identify whether PAX5, NOTCH1, and EBV latency genes participate in the oncogenic process of pediatric patients with classical Hodgkin lymphoma (cHL), the present study aimed to identify the variable expression of NOTCH1 among disease subtypes and to assess its effect on PAX5 expression. …”
Publicado 2020
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199“…RESULTS: The present study found that chronic cerebral hypoperfusion following BCAS induced cerebral white matter demyelination and cognitive impairment, accompanied with elevated expression of the immunoproteasomes LMP2 and LMP7, activation of astrocytes and microglia, and increased production of inflammatory cytokines (e.g., interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-10, transforming growth factor-β1 (TGFβ1), and insulin-like growth factor-1 (IGF-1)). …”
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200por Bernasconi, Michele, Berger, Christoph, Sigrist, Jürg A, Bonanomi, Athos, Sobek, Jens, Niggli, Felix K, Nadal, David“…RESULTS: To compare quantitative gene transcription in the BL cell lines Namalwa, Raji, Akata, Jijoye, and P3HR1, we developed an oligonucleotide microarray chip, including 17 housekeeping genes, six latent EBV genes (EBNA1, EBNA2, EBNA3A, EBNA3C, LMP1, LMP2), and four lytic EBV genes (BZLF1, BXLF2, BKRF2, BZLF2), and used the cell line B95.8 as a reference for EBV gene transcription. …”
Publicado 2006
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