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21por Lao, Thuan Duc, Nguyen, Tuan Anh Hoang, Ngo, Kha Dong, Thieu, Hue Hong, Nguyen, Minh Trong, Nguyen, Dung Huu, Le, Thuy Ai Huyen“…No LMP-1 expression was observed, and only 1 of 100 specimens was detected with LMP-2 positive in healthy samples. In the combination of LMP-1 (+) and/or LMP-2 (+), the frequency of positive was 53.76%, greater than each gene expression. …”
Publicado 2019
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22por Li, Wenzhe, Okabe, Atsushi, Usui, Genki, Fukuyo, Masaki, Matsusaka, Keisuke, Rahmutulla, Bahityar, Mano, Yasunobu, Hoshii, Takayuki, Funata, Sayaka, Hiura, Nobuhiro, Fukayama, Masashi, Tan, Patrick, Ushiku, Tetsuo, Kaneda, Atsushi“…Moreover, there was significant enrichment of critical cancer pathway–related genes (eg, FZD5) in the downstream of EHF. EBV protein LMP2A caused upregulation of EHF via phosphorylation of STAT3. …”
Publicado 2021
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23por Kamara, Saidu, Guo, Yanru, Wen, He, Liu, Ying, Liu, Lei, Zheng, Maolin, Zhang, Jing, Zhou, Luqi, Chen, Jun, Zhu, Shanli, Zhang, Lifang“…In this study, an alternative format for bispecific molecules was constructed and investigated, named Z(LMP)110-277 and Z(LMP)277-110, that targets Epstein-Barr virus latent membrane protein 1 (LMP1) and latent membrane protein 2 (LMP2). Surface plasmon resonance (SPR), indirect immunofluorescence assay, co-immunoprecipitation, and near-infrared (NIR) imaging clearly demonstrated that Z(LMP)110-277 and Z(LMP)277-110 have good binding affinity and specificity for both LMP1 and LMP2 in vitro and in vivo. …”
Publicado 2023
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24por Engels, Niklas, Merchant, Mark, Pappu, Rajita, Chan, Andrew C., Longnecker, Richard, Wienands, Jürgen“…In latently infected B lymphocytes, the Epstein-Barr virus (EBV) suppresses signal transduction from the antigen receptor through expression of the integral latent membrane protein 2A (LMP2A). At the same time, LMP2A triggers B cell survival by a yet uncharacterized maintenance signal that is normally provided by the antigen receptor. …”
Publicado 2001
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25“…This review summarizes the role of EBV-encoded LMP2A in EBV-associated viral latency and cancers. …”
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26“…Apart from HLA-B27, the LMP2 gene has been shown to play a role in the pathogenesis of AS as well as AAU in AS. …”
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27por Yeo, In Jun, Lee, Min Jae, Baek, Ahruem, Miller, Zachary, Bhattarai, Deepak, Baek, Yu Mi, Jeong, Hyun Jung, Kim, Yun Kyung, Kim, Dong-Eun, Hong, Jin Tae, Kim, Kyung Bo“…Overall, this study indicates that there may exist a potential link between LMP2/Y and microglia-mediated neuroinflammation and that inhibition of these subunits may offer a new therapeutic strategy for AD.…”
Publicado 2019
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28“…BACKGROUND: Insulin dependent diabetes mellitus (IDDM) is a kind of heterogeneous disease caused by the interaction of polygene inheritance and environmental factors. The LMP2 and LMP7 are 2 loci in LMP gene, and although genetic association between LMP2 and LMP7 polymorphisms were reported, the results are inconclusive. …”
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29por Xiang, Yu, Tian, Miaomiao, Huang, Juan, Li, Yueyi, Li, Guangqi, Li, Xue, Jiang, Zedong, Song, Xiangrong, Ma, Xuelei“…RESULTS: We developed an LMP2-mRNA lipid nanoparticle (C2@mLMP2) that can be delivered to tumor-draining lymph nodes. …”
Publicado 2023
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30“…BACKGROUND: The roles of low molecular mass polypeptide 2 (LMP2) and transporter-associated with antigen processing (TAP2) in tumorigenesis are controversial. …”
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31“…Further, a xenograft model of prostate cancer was studied to test the in vivo effects of LMP2 inhibition. RESULTS: A small molecule inhibitor of the immunoproteasome subunit LMP2, UK-101, induced apoptosis of PC-3 cells and resulted in significant inhibition (∼50–60%) of tumour growth in vivo. …”
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32por Sun, Haiyan, Lee, Choon-myung, Tripathi, Shweta, Kim, Kyung-Bo, Morgan, Edward T.“…The immunoproteasome subunit LMP2 (large multifunctional peptidase 2) was significantly expressed in hepatocytes under basal conditions, and IL-1 induced LMP2 within 6–12 h of treatment. …”
Publicado 2012
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33por Gainullin, Murat R., Zhukov, Ilya Yu, Zhou, Xiaoying, Mo, Yingxi, Astakhova, Lidiia, Ernberg, Ingemar, Matskova, Liudmila“…We used LMP2A transformed NPC cell lines to analyze cofilin expression. …”
Publicado 2017
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34por Yang, Lan, Ji, Yu, Chen, Ling, Li, Mei, Wu, Fei, Hu, Jianming, Jiang, Jinfang, Cui, Xiaobin, Chen, Yunzhao, Pang, Lijuan, Wei, Yutao, Li, Feng“…We found a clear increased risk of ESCC in the Kazakh population for the heterozygous LMP2 R/C genotype and the homozygous C/C genotype (OR = 1.470, 95%CI = 1.076–2.008, p = 0.015 forLMP2R/C; OR = 2.048, 95% CI = 1.168–3.591, p = 0.011 for LMP2 C/C). …”
Publicado 2017
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35por Petersen, Antonia, Kutsche, Hanna Sarah, Nippert, Franziska, Schreckenberg, Rolf, Schulz, Rainer, Schlüter, Klaus-Dieter“…During the early phase of adaptation, proteasome subunit low molecular weight protein (LMP)-2 was induced. Inhibition of LMP-2 up-regulation by siRNA attenuated the process of successful adaptation. …”
Publicado 2020
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36por Zheng, Shixing, Matskova, Liudmila, Zhou, Xiaoying, Xiao, Xue, Huang, Guangwu, Zhang, Zhe, Ernberg, Ingemar“…EBV‐encoded latent membrane protein 2A (LMP2A) is expressed in most NPCs enhancing migration and invasion. …”
Publicado 2020
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37por Mishto, Michele, Bellavista, Elena, Ligorio, Claudia, Textoris-Taube, Kathrin, Santoro, Aurelia, Giordano, Mara, D'Alfonso, Sandra, Listì, Florinda, Nacmias, Benedetta, Cellini, Elena, Leone, Maurizio, Grimaldi, Luigi M.E., Fenoglio, Chiara, Esposito, Federica, Martinelli-Boneschi, Filippo, Galimberti, Daniela, Scarpini, Elio, Seifert, Ulrike, Amato, Maria Pia, Caruso, Calogero, Foschini, Maria P., Kloetzel, Peter M., Franceschi, Claudio“…CONCLUSION/SIGNIFICANCE: The immunoproteasome LMP2 60HH variant reduces the risk to develop MS amongst Italian HLA-A*02+ females. …”
Publicado 2010
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38“…In this study, we investigated whether LMP1 and LMP2A co-expression in a transgenic mouse model alters B cell maturation and the response to antigen, and whether LMP2A modulates LMP1 function. …”
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39por Engels, Niklas, Yigit, Gökhan, Emmerich, Christoph H, Czesnik, Dirk, Schild, Detlev, Wienands, Jürgen“…RESULTS: We have reanalyzed LMP2A signaling using B cells in which LMP2A is expressed in an inducible manner in the absence of any other EBV signaling protein. …”
Publicado 2012
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40por Wu, Yang, Liu, Dong-Fang, Zhang, Jing-Jing, Li, Xiao, Lu, Zi-Peng, Shi, Guo-Dong, Yuan, Hao, Ge, Yu-Gang, Wu, Peng-Fei, Wang, Yan, Jiang, Kui-Rong, Miao, Yi“…Recent studies have reported the association of LMP2-60 G>A (rs17587) and LMP7-145 C>A (rs2071543) polymorphisms with various types of cancers, but the outcomes remained inconsistent. …”
Publicado 2017
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