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41por Zhu, Jinshun, Kamara, Saidu, Cen, Danwei, Tang, Wanlin, Gu, Meiping, Ci, Xingyuan, Chen, Jun, Wang, Lude, Zhu, Shanli, Jiang, Pengfei, Chen, Shao, Xue, Xiangyang, Zhang, Lifang“…Therefore, the therapeutic approach of targeting the LMP1/LMP2A protein and subsequently blocking the LMP1/LMP2A-mediated signalling pathway has been considered for treating patients with NPC. …”
Publicado 2020
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42Molecular Interactions between Two LMP2A PY Motifs of EBV and WW Domains of E3 Ubiquitin Ligase AIP4por Seo, Min-Duk, Seok, Seung-Hyeon, Kim, Ji-Hun, Choi, Ji Woong, Park, Sung Jean, Lee, Bong-Jin“…Interactions involving Epstein–Barr virus (EBV) LMP2A and Nedd4 family E3 ubiquitin–protein ligases promote the ubiquitination of LMP2A-associated proteins, which results in the perturbation of normal B-cell signaling. …”
Publicado 2021
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43por Chen, Xing-Yong, Wan, Shao-Fen, Yao, Nan-Nan, Lin, Ze-Jing, Mao, Yan-Guang, Yu, Xiao-Hua, Wang, Yin-Zhou“…Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2 (LMP2) in the pathophysiology of ischemia stroke. …”
Publicado 2021
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44por Tertipis, Nikolaos, Haeggblom, Linnea, Grün, Nathalie, Nordfors, Cecilia, Näsman, Anders, Dalianis, Tina, Ramqvist, Torbjörn“…Expression of TAP1 and TAP2 was correlated, as was LMP2 to LMP7. LMP2 and LMP7 expression was also associated to HLA class I expression. …”
Publicado 2015
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45por Sohn, Dae-Hee, Sohn, Hyun-Jung, Lee, Hyun-Joo, Lee, Seon-Duk, Kim, Sueon, Hyun, Seung-Joo, Cho, Hyun-Il, Cho, Seok-Goo, Lee, Suk-Kyeong, Kim, Tai-Gyu“…To determine whether there were changes in LMP1- or LMP2a-specific immune responses, subsequent peripheral blood mononuclear cells (PBMCs) samples were analyzed. …”
Publicado 2015
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46por Wang, Fangjun, Chen, Weichang, Liu, Pengfei, Zhou, Jundong, Liu, Bingtuan, Ye, Wu, Wang, Wenping, Shen, Xiuyun“…In this study, lentivirus-mediated RNA interference (RNAi) was applied to inhibit latent membrane protein 2A (LMP2A) gene expression, in order to explore the effects of LMP2A silencing on the growth of an Epstein-Barr virus-associated gastric carcinoma (EBVaGC) cell line in vitro. …”
Publicado 2017
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47“…The results suggest that immunization with DNA vaccines carrying fusion gene EBV-LMP2-CD40L can induce specific immunity more effectively than the plasmid expression individual antigen EBV-LMP2. …”
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48“…OBJECTIVE: The pre-mRNA of the Epstein–Barr virus LMP2 (latent membrane protein 2) has a region of unusual RNA structure that partially spans two consecutive exons and the entire intervening intron; suggesting RNA folding might affect splicing—particularly via interactions with human regulatory proteins. …”
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49por Zhu, Jinshun, Kamara, Saidu, Cen, Danwei, Tang, Wanlin, Gu, Meiping, Ci, Xingyuan, Chen, Jun, Wang, Lude, Zhu, Shanli, Jiang, Pengfei, Chen, Shao, Xue, Xiangyang, Zhang, LifangEnlace del recurso
Publicado 2020
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50por Cho, Seok-Goo, Kim, Nayoun, Sohn, Hyun-Jung, Lee, Suk Kyeong, Oh, Sang Taek, Lee, Hyun-Joo, Cho, Hyun-Il, Yim, Hyeon Woo, Jung, Seung Eun, Park, Gyeongsin, Oh, Joo Hyun, Choi, Byung-Ock, Kim, Sung Won, Kim, Soo Whan, Chung, Nak Gyun, Lee, Jong Wook, Hong, Young Seon, Kim, Tai-Gyu“…Circulating IFN-γ secreting LMP1 and LMP2a-specific T cells within the peripheral blood corresponded with decline in plasma EBV DNA levels in patients. …”
Publicado 2015
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51por Zhang, Chaoting, Tan, Qin, Li, Shance, Shen, Luyan, Zhang, Jingtao, Liu, Ying, Yang, Wenjun, Lu, Zheming“…BACKGROUND: Latent membrane protein-2A (LMP2A)-specific TCR-engineered T cells could be a promising treatment approach to Epstein–Barr virus-associated malignancies. …”
Publicado 2021
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52por Kong, Qing-Li, Hu, Li-Juan, Cao, Jing-Yan, Huang, Yi-Jun, Xu, Li-Hua, Liang, Yi, Xiong, Dan, Guan, Su, Guo, Bao-Hong, Mai, Hai-Qiang, Chen, Qiu-Yan, Zhang, Xing, Li, Man-Zhi, Shao, Jian-Yong, Qian, Chao-Nan, Xia, Yun-Fei, Song, Li-Bing, Zeng, Yi-Xin, Zeng, Mu-Sheng“…Additionally, LMP2A increases the number of cancer initiating cells in a xenograft tumor formation assay. …”
Publicado 2010
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53por Du, Zi-Ming, Hu, Li-Fu, Wang, Hai-Yun, Yan, Li-Xu, Zeng, Yi-Xin, Shao, Jian-Yong, Ernberg, Ingemar“…Taken together, up-regulation of miR-155 in NPC is partly driven by LMP1 and LMP2A, and results in downregulation of JMJD1A, which is associated with N stage and poor prognosis of NPC patients. …”
Publicado 2011
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54por Gross, Henrik, Hennard, Christine, Masouris, Ilias, Cassel, Christian, Barth, Stephanie, Stober-Grässer, Ute, Mamiani, Alfredo, Moritz, Bodo, Ostareck, Dirk, Ostareck-Lederer, Antje, Neuenkirchen, Nils, Fischer, Utz, Deng, Wen, Leonhardt, Heinrich, Noessner, Elfriede, Kremmer, Elisabeth, Grässer, Friedrich A.“…Finally, hnRNP K, when co-expressed with EBNA2, strongly enhances viral latent membrane protein 2A (LMP2A) expression by an unknown mechanism as we did not detect a direct association of hnRNP K with DNA-bound EBNA2 in gel shift experiments. …”
Publicado 2012
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55por Liang, Jiezhen, Zheng, Shixing, Xiao, Xue, Wei, Jiazhang, Zhang, Zhe, Ernberg, Ingemar, Matskova, Liudmila, Huang, Guangwu, Zhou, Xiaoying“…Epstein-Barr virus (EBV)-encoded latent membrane protein 2A (LMP2A) promotes the motility of nasopharyngeal carcinoma (NPC) cells. …”
Publicado 2017
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56“…During latency, EBV expresses Latent Membrane Protein 2A (LMP2A) along with few other genes. We previously showed that LMP2A causes downregulation of HLA-ABC surface expression in EBV associated gastric carcinomas. …”
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57“…The polymerase chain reaction (PCR) was performed to assess the presence of EBNA-1, EBNA-2, LMP-1, LMP-2 in nasopharyngeal brush samples from Vietnamese NPC patients and non-cancer controls. …”
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58por Jo, Hyeong-A, Hyun, Seung-Joo, Hyun, You-Seok, Lee, Yong-Hun, Kim, Sun-Mi, Baek, In-Cheol, Sohn, Hyun-Jung, Kim, Tai-Gyu“…Latent membrane protein 2A (LMP2A), a latent Ag commonly expressed in Epstein-Barr virus (EBV)-infected host cells, is a target for adoptive T cell therapy in EBV-associated malignancies. …”
Publicado 2022
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59por Zvejniece, Laura, Kozireva, Svetlana, Rudevica, Zanna, Leonciks, Ainars, Ehlin-Henriksson, Barbro, Kashuba, Elena, Kholodnyuk, Irina“…We revealed that CCR1 is expressed at high mRNA and protein levels in two CD10-negative BL cell lines with co-expression of the EBV latent genes EBNA2, LMP1, and LMP2. Low levels of CCR2 transcripts were found in three BL cell lines. …”
Publicado 2022
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60“…The frequencies of the HLA-A*1101/LMP2-SSC pentamer at + 30, + 60, and + 90 days were significantly decreased compared with those in healthy controls (p = 0.009, 0.019, and 0.039, respectively); however, the frequencies of the HLA-A*1101/LMP2-SSC pentamer did not differ significantly among patients at + 30, + 60, and + 90 days (p = 0.886). …”
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