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121“…Proteasome activity (caspase-, chymotrypsin-, and trypsin- like), protein content of standard proteasome (β1, β5 and β2) and immunoproteasome (LMP2, LMP7 and MECL-1) catalytic subunits were determined in the gastrocnemius muscle. …”
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122por Sijts, Alice J.A.M., Ruppert, Thomas, Rehermann, Barbara, Schmidt, Marion, Koszinowski, Ulrich, Kloetzel, Peter-M.“…Interferon (IFN)-γ–induced cells express the proteasome subunits low molecular weight protein (LMP)2, LMP7, and MECL-1 (multicatalytic endopeptidase complex–like 1), leading to the formation of immunoproteasomes. …”
Publicado 2000
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123por Greijer, A. E., Stevens, S. J., Verkuijlen, S. A., Juwana, H., Fleig, S. C., Verschuuren, E. A., Hepkema, B. G., Cornelissen, J. J., Brooimans, R. A., Verdonck, L. F., Middeldorp, J. M.“…All SCT with cell-associated EBV DNA showed BARTs and EBNA1 expression, while LMP1 and LMP2 mRNA was found in 1 and 3 cases, respectively. …”
Publicado 2012
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124por Spielmann, Guillaume, Bollard, Catherine M., Kunz, Hawley, Hanley, Patrick J., Simpson, Richard J.“…The number (fold difference from PRE) of T-cells specific for CMV pp65 (2.6), EBV LMP2A (2.5), and EBV BMLF1 (4.4) was greater among the VSTs expanded POST. …”
Publicado 2016
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125“…Here, we show that single short peptides of <8-mer from Latent Membrane Protein 2 (LMP2) of Epstein Barr Virus (EBV) can bind HLA-A*11:01 and stimulate CD8(+) cells. …”
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126por Karpova, Ya.D., Ustichenko, V.D., Alabedal’karim, N.M., Stepanova, A.A., Lyupina, Yu.V., Boguslavski, K.I., Bozhok, G.A., Sharova, N.P.“…In both phases, the level of the subunits LMP2 and LMP7 in the total pool of mononuclear cells and Kupffer cells increases, with maximum values on days 1 and 7. …”
Publicado 2017
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127por Rao, Sieta P, Rechsteiner, Markus P, Berger, Christoph, Sigrist, Jürg A, Nadal, David, Bernasconi, Michele“…Furthermore, 5-Azacytidine induced upregulation of the latent EBV genes LMP2A, LMP2B, and EBNA2 in a similar fashion as observed following switching of latent to lytic EBV upon cross-linking of the B-cell receptor. …”
Publicado 2007
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128por Sugiura, M., Imai, S., Tokunaga, M., Koizumi, S., Uchizawa, M., Okamoto, K., Osato, T.“…Latent membrane protein (LMP) 2A mRNA was detected in three of seven cases; however, neither LMP1 nor LMP2B mRNA was detected in any of the tumours tested. …”
Publicado 1996
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129por Eom, Hyeon-Seok, Choi, Beom K., Lee, Youngjoo, Lee, Hyewon, Yun, Tak, Kim, Young H., Lee, Je-Jung, Kwon, Byoung S.“…CD8(+) T-cell responses against different LMP2A peptides in each patient were determined, and the most effective peptides were used to produce EBViNT. …”
Publicado 2016
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130por Yigit, Burcu, Halibozek, Peter J., Chen, Shih-Shih, O'Keeffe, Michael S., Arnason, Jon, Avigan, David, Gattei, Valter, Bhan, Atul, Cen, Osman, Longnecker, Richard, Chiorazzi, Nicholas, Wang, Ninghai, Engel, Pablo, Terhorst, Cox“…Similarly, progression of a murine B cell lymphoma, LMP2A/λMyc, was also eliminated by αSlamf6. But, surprisingly, αSLAMF6 neither eliminated TCL1-192 nor LMP2A/λMyc cells, which resided in the peritoneal cavity or omentum. …”
Publicado 2016
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131por Ungerleider, Nathan, Concha, Monica, Lin, Zhen, Roberts, Claire, Wang, Xia, Cao, Subing, Baddoo, Melody, Moss, Walter N., Yu, Yi, Seddon, Michael, Lehman, Terri, Tibbetts, Scott, Renne, Rolf, Dong, Yan, Flemington, Erik K.“…In addition, we identified circular RNAs expressed during reactivation including backsplicing from exon 8 to exon 2 of the LMP2 gene and a highly expressed circular RNA derived from intra-exonic backsplicing within the BHLF1 gene. …”
Publicado 2018
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132“…RESULTS: In this study, the alignment analysis based on structural similarity allows the prediction of 48 potential interactions between 27 human RPs and the EBV proteins EBNA1, LMP1, LMP2A, and LMP2B. Gene ontology analysis of the putative protein-protein interactions (PPIs) reveals their probable involvement in RNA binding, ribosome biogenesis, metabolic and biosynthetic processes, and gene regulation. …”
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133por Noman, Muhammad Zaeem, Bocci, Irene Adelaide, Karam, Manale, Moer, Kris Van, Bosseler, Manon, Kumar, Akinchan, Berchem, Guy, Auclair, Christian, Janji, Bassam“…Here, we show that ACB1801 upregulates the mRNA expression of several proteins of the MHC-I such as Transporter Associated with antigen Processing TAP1 and 2, Tapasin and Lmp2 (hereafter referred to as MHC-I signature) in melanoma cells. …”
Publicado 2022
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134por Bollard, Catherine M., Aguilar, Laura, Straathof, Karin C., Gahn, Benedikt, Huls, M. Helen, Rousseau, Alexandra, Sixbey, John, Gresik, M. Victoria, Carrum, George, Hudson, Melissa, Dilloo, Dagmar, Gee, Adrian, Brenner, Malcolm K., Rooney, Cliona M., Heslop, Helen E.“…Tetramer and functional analyses showed that T cells reactive with the tumor-associated antigen LMP2 were present in the infused lines, expanded in peripheral blood after infusion, and also entered tumor. …”
Publicado 2004
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135por Chen, S, Kammerl, I E, Vosyka, O, Baumann, T, Yu, Y, Wu, Y, Irmler, M, Overkleeft, H S, Beckers, J, Eickelberg, O, Meiners, S, Stoeger, T“…In contrast, IL-4 triggered alternative (M2) activation of primary alveolar macrophages was accompanied by a transcriptionally independent amplified expression of LMP2 and LMP7 and an increase in immunoproteasome activity. …”
Publicado 2016
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136por Fessahaye, Ghimja, Elhassan, Ahmed M., Elamin, Elwaleed M., Adam, Ameera A. M., Ghebremedhin, Anghesom, Ibrahim, Muntaser E.“…Expression of Latent Membrane Protein-2a (LMP2a) was also assessed by immunohistochemistry in a subset of 45 samples. …”
Publicado 2017
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137“…Furthermore, cellular immunotherapy with engineered cytotoxic T lymphocytes targeted against LMP1 and LMP2 have shown encouraging results with durable CRs as either maintenance therapy after initial induction chemotherapy or in the relapsed/refractory setting. …”
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138por Sinha, Debottam, Srihari, Sriganesh, Beckett, Kirrliee, Le Texier, Laetitia, Solomon, Matthew, Panikkar, Archana, Ambalathingal, George R, Lekieffre, Lea, Crooks, Pauline, Rehan, Sweera, Neller, Michelle A., Smith, Corey, Khanna, Rajiv“…METHODS: Taking a clue from these studies, we developed a highly efficient EBV-specific T-cell expansion process using a replication-deficient AdE1-LMPpoly vector that specifically targets EBV-encoded nuclear antigen 1 (EBNA1) and latent membrane proteins 1 and 2 (LMP1 and LMP2), expressed in latency II malignancies. RESULTS: These allogeneic EBV-specific T cells efficiently recognized human leukocyte antigen (HLA)-matched EBNA1-expressing and/or LMP1 and LMP2-expressing malignant cells and demonstrated therapeutic potential in a number of in vivo models, including EBV lymphomas that emerged spontaneously in humanized mice following EBV infection. …”
Publicado 2021
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139por Huang, Peng, Dong, Li, Lu, Xiaomei, Zhang, Yuanyuan, Chen, Hongbo, Wang, Jie, Zhang, Yun, Su, Jing, Yu, Rongbin“…HLA-DOB rs7383287 and LMP2 rs17587 were independent factors of infection chronicity. …”
Publicado 2014
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140“…Immunization with various vaccine platforms expressing the EBV latent proteins EBNA1, LMP1, and/or LMP2 promoted specific CD4+ and CD8+ cytotoxic responses with anti-tumor activity. …”
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