Mostrando 1 - 20 Resultados de 257 Para Buscar '"LMP2"', tiempo de consulta: 2.13s Limitar resultados
  1. 1
    por Sun, Liying, Hao, Yanzhe, Wang, Zhan, Zeng, Yi
    Publicado 2018
    “…However, the model cells carrying LMP2 have still not been established to assess the oncolytic effect of LMP2-related vaccines at present. …”
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    Constructing TC-1-GLUC-LMP2 Model Tumor Cells to Evaluate the Anti-Tumor Effects of LMP2-Related Vaccines
  2. 2
    “…Although frequently expressed in EBV-positive malignancies, the role that Latent membrane protein 2A and 2B (LMP2A, LMP2B) play in the oncogenic process remains obscure. …”
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    The EBV-encoded Latent Membrane Proteins, LMP2A and LMP2B, Limit the Actions of Interferon by Targeting Interferon Receptors for Degradation
  3. 3
    “…The LMP2 gene is transcribed from a promoter containing an interferon (IFN)-γ-response factor element; thus, the IFN-γ-signal strongly induces LMP2 expression. …”
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    Molecular Mechanisms of Uterine Leiomyosarcomas: Involvement of Defect in LMP2 Expression
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    “…In cell lines, the Epstein–Barr virus (EBV)-encoded protein latent membrane protein 2A (LMP2A) protects B-cells from apoptosis by blocking B-cell receptor (BCR) signalling. …”
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    Epstein–Barr virus LMP2A imposes sensitivity to apoptosis
  5. 5
    “…LMP2 may be a potential diagnostic-biomarker and targeted-molecule for a new therapeutic approach.…”
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    Involvement of proteasome β1i subunit, LMP2, on development of uterin leiomyosarcma
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    “…ML604440, an specific LMP2 inhibitor, had no significant impact on the platelet count of ITP mice, while ONX-0914 (an inhibitor of both LMP2 and LMP7) increased the number of platelets. …”
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    Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia
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    “…Due to the lack of therapeutic vaccines for NPC, we selected EBV latent membrane protein 2 (LMP2) as a preferable targeting antigen to develop a lipid-based LMP2-mRNA (mLMP2) vaccine. …”
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    A lipid-based LMP2-mRNA vaccine to treat nasopharyngeal carcinoma
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    “…A negative reaction with anti-LMP2 was observed in the cytoplasm and nuclei of control skin cells. …”
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    Immunohistochemical Identification and Assessment of the Location of Immunoproteasome Subunits LMP2 and LMP7 in Acquired Cholesteatoma
  9. 9
    “…Furthermore, analysis of a human uterine LMS cell line clarified the biological significance of LMP2 in malignant myometrium transformation and cell cycle, thus implicating LMP2 as an anti-tumorigenic candidate. …”
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    Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy
  10. 10
    “…In this study, four EBV LMP-2-binding affibodies (Z(EBV LMP-2)12, Z(EBV LMP-2)132, Z(EBV LMP-2)137, and Z(EBV LMP-2)142) were identified by screening a phage-displayed LMP-2 peptide library for molecular imaging and targeted therapy in EBV xenograft mice model. …”
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    Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma
  11. 11
    “…Therefore, the aim of this study was to explore the contribution of the immunoproteasome subunit low molecular weight protein 2 (LMP2) in neurobehavioral functions. METHODS: Male LMP2 gene completed knockout (LMP2-KO) and littermate wild type (WT) Sprague–Dawley (SD) rats aged 12-month-old were used for neurobehavioral testing and detection of proteins expression by western blotting and immunofluorescence. …”
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    LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions
  12. 12
    Publicado 1995
    “…Recently, four genes (TAP1, TAP2, LMP2, LMP7) involved or potentially involved in the processing and transport of major histocompatibility complex class I-associated antigen to the endoplasmic reticulum have been identified. …”
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    Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter
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    “…We found LMP2 expression to be absent in human LMS, but present in human LMA. …”
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    Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma
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    “…In summary we provide evidence for a critical role of the IP subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7 for the control of cerebral Toxoplasma gondii infection and subsequent neuroinflammation.…”
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    The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis
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    Identification and characterization of novel B-cell epitopes within EBV latent membrane protein 2 (LMP2)
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    “…Latent membrane protein 1 (LMP1) and LMP2A affect cell growth in both epithelial cells and lymphocytes. …”
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    Transcriptome Changes Induced by Epstein-Barr Virus LMP1 and LMP2A in Transgenic Lymphocytes and Lymphoma
  17. 17
    “…OBJECTIVE: To investigate a possible association of LMP2/LMP7 genes with chronic hepatitis C virus (HCV) infection, and to assess whether LMP2/LMP7 genes could influence the outcomes of HCV infection among drug users. …”
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    The association between the genetic polymorphisms of LMP2/LMP7 and the outcomes of HCV infection among drug users()
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    “…Latent membrane protein 2A (LMP2A) of EBV supports activation and proliferation of infected B cells and is expressed in many types of EBV-associated cancer. …”
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    Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells
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    “…This circRNA, which we term circLMP-2_e5, can be universally detected in a panel of EBV-positive cell lines modelling different latency programs. …”
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    Identification and characterization of a novel Epstein-Barr Virus-encoded circular RNA from LMP-2 Gene
  20. 20
    “…In the present study, we examined the expression of LMP1 and LMP2A in ENKTL, and investigated the correlations between LMP1 and LMP2A expression with clinicopathological characteristics of ENKTL patients. …”
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    LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL)
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