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1“…However, the model cells carrying LMP2 have still not been established to assess the oncolytic effect of LMP2-related vaccines at present. …”
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2por Shah, Khilan M., Stewart, Suzanne E, Wei, Wenbin, Woodman, Ciaran B J, O’Neil, John D, Dawson, Christopher W., Young, Lawrence S“…Although frequently expressed in EBV-positive malignancies, the role that Latent membrane protein 2A and 2B (LMP2A, LMP2B) play in the oncogenic process remains obscure. …”
Publicado 2009
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3por Hayashi, Takuma, Shimamura, Yuto, Saegusa, Taro, Horiuchi, Akiko, Kobayashi, Yukihiro, Hiraoka, Nobuyoshi, Kanai, Yae, Aburatani, Hiroyuki, Sano, Kenji, Konishi, Ikuo“…The LMP2 gene is transcribed from a promoter containing an interferon (IFN)-γ-response factor element; thus, the IFN-γ-signal strongly induces LMP2 expression. …”
Publicado 2008
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4“…In cell lines, the Epstein–Barr virus (EBV)-encoded protein latent membrane protein 2A (LMP2A) protects B-cells from apoptosis by blocking B-cell receptor (BCR) signalling. …”
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5por Hayashi, Takuma, Horiuchi, Akiko, Sano, Kenji, Hiraoka, Nobuyoshi, Kasai, Mari, Ichimura, Tomoyuki, Nagase, Satoru, Ishiko, Osamu, Shiozawa, Tanri, Kanai, Yae, Yaegashi, Nobuo, Aburatani, Hiroyuki, Tonegawa, Susumu, Konishi, Ikuo“…LMP2 may be a potential diagnostic-biomarker and targeted-molecule for a new therapeutic approach.…”
Publicado 2011
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6por Du, Sheng-hong, Xiang, Yu-jiao, Liu, Lu, Nie, Mu, Hou, Yu, Wang, Ling, Li, Ban-ban, Xu, Miao, Teng, Qing-liang, Peng, Jun, Hou, Ming, Shi, Yan“…ML604440, an specific LMP2 inhibitor, had no significant impact on the platelet count of ITP mice, while ONX-0914 (an inhibitor of both LMP2 and LMP7) increased the number of platelets. …”
Publicado 2021
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7por Guo, Mengran, Duan, Xing, Peng, Xingchen, Jin, Zhaohui, Huang, Hai, Xiao, Wen, Zheng, Qian, Deng, Yongqi, Fan, Na, Chen, Kepan, Song, Xiangrong“…Due to the lack of therapeutic vaccines for NPC, we selected EBV latent membrane protein 2 (LMP2) as a preferable targeting antigen to develop a lipid-based LMP2-mRNA (mLMP2) vaccine. …”
Publicado 2023
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8“…A negative reaction with anti-LMP2 was observed in the cytoplasm and nuclei of control skin cells. …”
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9por Hayashi, Takuma, Horiuchi, Akiko, Sano, Kenji, Hiraoka, Nobuyoshi, Kasai, Mari, Ichimura, Tomoyuki, Sudo, Tamotsu, Tagawa, Yoh-ichi, Nishimura, Ryuichiro, Ishiko, Osamu, Kanai, Yae, Yaegashi, Nobuo, Aburatani, Hiroyuki, Shiozawa, Tanri, Konishi, Ikuo“…Furthermore, analysis of a human uterine LMS cell line clarified the biological significance of LMP2 in malignant myometrium transformation and cell cycle, thus implicating LMP2 as an anti-tumorigenic candidate. …”
Publicado 2011
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10por Zhu, Shanli, Chen, Jun, Xiong, Yirong, Kamara, Saidu, Gu, Meiping, Tang, Wanlin, Chen, Shao, Dong, Haiyan, Xue, Xiangyang, Zheng, Zhi-Ming, Zhang, Lifang“…In this study, four EBV LMP-2-binding affibodies (Z(EBV LMP-2)12, Z(EBV LMP-2)132, Z(EBV LMP-2)137, and Z(EBV LMP-2)142) were identified by screening a phage-displayed LMP-2 peptide library for molecular imaging and targeted therapy in EBV xenograft mice model. …”
Publicado 2020
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11por Chen, Xingyong, Mao, Yanguang, Guo, Yueting, Xiao, Dongyun, Lin, Zejing, Huang, Yiyi, Liu, Ying Chun, Zhang, Xu, Wang, Yinzhou“…Therefore, the aim of this study was to explore the contribution of the immunoproteasome subunit low molecular weight protein 2 (LMP2) in neurobehavioral functions. METHODS: Male LMP2 gene completed knockout (LMP2-KO) and littermate wild type (WT) Sprague–Dawley (SD) rats aged 12-month-old were used for neurobehavioral testing and detection of proteins expression by western blotting and immunofluorescence. …”
Publicado 2023
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12Publicado 1995“…Recently, four genes (TAP1, TAP2, LMP2, LMP7) involved or potentially involved in the processing and transport of major histocompatibility complex class I-associated antigen to the endoplasmic reticulum have been identified. …”
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13por Hayashi, Takuma, Horiuchi, Akiko, Sano, Kenji, Hiraoka, Nobuyoshi, Kanai, Yae, Shiozawa, Tanri, Tonegawa, Susumu, Konishi, Ikuo“…We found LMP2 expression to be absent in human LMS, but present in human LMA. …”
Publicado 2011
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14por French, Timothy, Israel, Nicole, Düsedau, Henning Peter, Tersteegen, Anne, Steffen, Johannes, Cammann, Clemens, Topfstedt, Eylin, Dieterich, Daniela, Schüler, Thomas, Seifert, Ulrike, Dunay, Ildiko Rita“…In summary we provide evidence for a critical role of the IP subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7 for the control of cerebral Toxoplasma gondii infection and subsequent neuroinflammation.…”
Publicado 2021
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16“…Latent membrane protein 1 (LMP1) and LMP2A affect cell growth in both epithelial cells and lymphocytes. …”
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17por Cui, Qian, Zhang, Yongxiang, Su, Jing, Shi, Chao, Lei, Na, Ding, Keqin, Li, Jun, Yu, Rongbin, Wang, Lu, Wang, Ning“…OBJECTIVE: To investigate a possible association of LMP2/LMP7 genes with chronic hepatitis C virus (HCV) infection, and to assess whether LMP2/LMP7 genes could influence the outcomes of HCV infection among drug users. …”
Publicado 2010
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18por Rancan, Chiara, Schirrmann, Leah, Hüls, Corinna, Zeidler, Reinhard, Moosmann, Andreas“…Latent membrane protein 2A (LMP2A) of EBV supports activation and proliferation of infected B cells and is expressed in many types of EBV-associated cancer. …”
Publicado 2015
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19por Tan, Ke-En, Ng, Wei Lun, Marinov, Georgi K., Yu, Ken Hung-On, Tan, Lu Ping, Liau, Ee Shan, Goh, Sook Yan, Yeo, Kok Siong, Yip, Kevin Y., Lo, Kwok-Wai, Khoo, Alan Soo-Beng, Yap, Lee-Fah, Ea, Chee-Kwee, Lim, Yat-Yuen“…This circRNA, which we term circLMP-2_e5, can be universally detected in a panel of EBV-positive cell lines modelling different latency programs. …”
Publicado 2021
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20LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL)por Mao, Yuan, Zhang, Da-Wei, Zhu, Huijun, Lin, Hong, Xiong, Lin, Cao, Qing, Liu, Ying, Li, Qing-Dong, Xu, Jia-Ren, Xu, Lin-Feng, Chen, Ren-Jie“…In the present study, we examined the expression of LMP1 and LMP2A in ENKTL, and investigated the correlations between LMP1 and LMP2A expression with clinicopathological characteristics of ENKTL patients. …”
Publicado 2012
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