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  1. 7641
    “…The lengths of the screw in the Denis III zone were (14.41 ± 4.40) mm for males and (14.09 ± 5.04) mm for females (p = 0.665), and in the Denis II+III zones were (36.25 ± 3.40) mm for males and (38.04 ± 4.60) mm for females (p = 0.005). The rates of LP-PSIS/LAIIS-PSIS were (0.36 ± 0.04) for males and (0.32 ± 0.03) for females (t = 4.943, p < 0.001). …”
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    Guidance for dysmorphic sacrum fixation with upper sacroiliac screw based on imaging anatomy study: techniques and indications
  2. 7642
    “…This review explains the concept of founder effect, then applies it to analyze published Jordanian BRCA variants, and concludes that nine pathogenic (P) and likely pathogenic (LP) BRCA2 variants together with one pathogenic BRCA1 variant are potential founder variants. …”
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    BRCA1/2 potential founder variants in the Jordanian population: an opportunity for a customized screening panel
  3. 7643
    “…RESULTS: In 65 families (63.1%), causative sequence variants (SVs) and clinically relevant copy number variants (CNVs) with a pathogenic or likely pathogenic (P/LP) level were identified. By incorporating coverage analysis to WES, a pathogenic or likely pathogenic CNV was detected in 15 families (16/103, 15.5%). …”
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    Diagnostic yield and novel candidate genes for neurodevelopmental disorders by exome sequencing in an unselected cohort with microcephaly
  4. 7644
    “…These molecules specifically target new cellular pathways, such as the adenosine triphosphate-citrate lyase (bempedoic acid), PCSK9 (inclisiran), angiopoietin-like 3 (ANGPTL3: evinacumab), microsomal triglyceride transfer protein (MTP: lomitapide), apolipoprotein B-100 (ApoB-100: mipomersen), apolipoprotein C-III (ApoC-III: volanesorsen, olezarsen), and lipoprotein (a) (Lp(a): pelcarsen, olpasiran). The authors are hopeful that the development of new treatment modalities alongside new therapeutic targets will further reduce patients’ risk of adverse cardiovascular events. …”
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    Established and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention
  5. 7645
    “…Our extensive examination of Operations Research (OR) methodologies reveals that Mixed-Integer Linear Programming (MILP) models are the most commonly used methodology, followed by Linear Program (LP), Dynamic Program (DP), and Data Envelopment Analysis (DEA) techniques. …”
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    Food bank operations: review of operation research methods and challenges during COVID-19
  6. 7646
    “…Roman: None. H. Liu: None. L.P. Chorich: None. Y. Li: None. J.E. Hall: None. …”
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    FRI410 ESR1 Variants Reduce Estrogen Receptor Alpha Expression In Women With Unexplained Infertility
  7. 7647
    “…RESULTS: DSS-induced acute colitis model was characterized by a reduced BW, AUC of BW, serum calcium, higher DAI, AUC of DAI, shortened colon length, elevated MPO activity, worsened histologic inflammation, increased mononuclear cell numbers in mesenteric lymph nodes (MLNs) and colonic lamina propria (LP), and enhanced proteins and mRNA levels of TNF-α and IFN-γ. 1,25(OH)(2)D(3) markedly increased expressions of TJ proteins and mRNA and decreased the FITC-D permeability and the level of LPS. …”
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    Protective role of 1,25(OH)(2)vitamin D(3) in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice
  8. 7648
    “…Quantitative emphysema measurements included percent low lung attenuation (%LAA) ≤ −950 HU, ≤ − 910 HU and mean lung attenuation at the 15(th) percentile on lung attenuation curve (LP15A). Multiple regression analysis was performed to determine plasma biomarkers associated with emphysema independent of covariates age, gender, smoking status, body mass index and FEV(1). …”
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    The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes
  9. 7649
    por Glithero, N.J., Ramsden, S.J., Wilson, P.
    Publicado 2012
    “…Previous research has captured financial costs and benefits through linear programming (LP) approaches, whilst environmental and energy metrics have been largely been undertaken within life cycle analysis (LCA) frameworks. …”
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    Farm systems assessment of bioenergy feedstock production: Integrating bio-economic models and life cycle analysis approaches
  10. 7650
    “…Furthermore, we generated draft genomes of four additional L. reuteri strains isolated from pig faeces or lower GI tract, lp167-67, pg-3b, 20-2 and 3c6, and subjected all five genomes to a comparative genomic analysis together with the previously completed genome of strain I5007. …”
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    The pan-genome of Lactobacillus reuteri strains originating from the pig gastrointestinal tract
  11. 7651
    por Kostich, Walter, Hamman, Brian D., Li, Yu-Wen, Naidu, Sreenivasulu, Dandapani, Kumaran, Feng, Jianlin, Easton, Amy, Bourin, Clotilde, Baker, Kevin, Allen, Jason, Savelieva, Katerina, Louis, Justin V., Dokania, Manoj, Elavazhagan, Saravanan, Vattikundala, Pradeep, Sharma, Vivek, Das, Manish Lal, Shankar, Ganesh, Kumar, Anoop, Holenarsipur, Vinay K., Gulianello, Michael, Molski, Ted, Brown, Jeffrey M., Lewis, Martin, Huang, Yanling, Lu, Yifeng, Pieschl, Rick, O’Malley, Kevin, Lippy, Jonathan, Nouraldeen, Amr, Lanthorn, Thomas H., Ye, Guilan, Wilson, Alan, Balakrishnan, Anand, Denton, Rex, Grace, James E., Lentz, Kimberley A., Santone, Kenneth S., Bi, Yingzhi, Main, Alan, Swaffield, Jon, Carson, Ken, Mandlekar, Sandhya, Vikramadithyan, Reeba K., Nara, Susheel J., Dzierba, Carolyn, Bronson, Joanne, Macor, John E., Zaczek, Robert, Westphal, Ryan, Kiss, Laszlo, Bristow, Linda, Conway, Charles M., Zambrowicz, Brian, Albright, Charles F.
    Publicado 2016
    “…Studies in mice showed that one such inhibitor, LP-935509, caused a reduced pain response in phase II formalin and reversed fully established pain behavior following the SNL procedure. …”
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    Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
  12. 7652
    “…Intragastric administration of L. lactis MG1363 FnBPA(+) (pValac::dts::IL-4) was able to decrease the severity of colitis, with animals showing decreased levels of IL-12, IL-6 and MPO activity; and increased levels of IL-4 and IL-10. Finally, LP-isolated cells from mice administered TNBS were immunophenotyped so that the main IL-4 and IL-10 producers were identified. …”
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    Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells
  13. 7653
    “…Participants completed baseline demographic, alcohol-related and other psychological questionnaires online and were randomised to HeLP-Alcohol, a six-module DHI with weekly reminder prompts (phone, email or text message), which mirrors face-to-face treatment, or to face-to-face treatment at CDAS. …”
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    DIAMOND (DIgital Alcohol Management ON Demand): a mixed methods feasibility RCT and embedded process evaluation of a digital health intervention to reduce hazardous and harmful alcohol use
  14. 7654
    “…In the SOAR trial, subjects with elevated baseline serum liver enzymes (ALT, GGT) and cardiovascular risk markers (TG, Lp-PLA2, LDL-C) experienced significant reductions. …”
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    SAT-LB004 Therapeutic Potential of LPCN 1144 in NAFLD and NASH
  15. 7655
    “…We report superior haplotypes upon phenotyping the subset of 3K RG panel, SD1‐H8 with haplotype frequency (HF) of 30.13% in 3K RG panel, MOC1‐H9 (HF: 23.08%), IPA1‐H14 (HF: 6.64%), DEP3‐H2 (HF: 5.59%), DEP1‐H2 (HF: 37.53%), SP1‐H3 (HF: 5.05%), LAX1‐H5 (HF: 1.56%), LP‐H13 (3.64%), OSH1‐H4 (5.52%), PHD1‐H14 (HF: 15.21%), AGO7‐H15 (HF: 3.33%), ROC5‐H2 (31.42%), RSR1‐H8 (HF: 4.20%) and OsNAS3‐H2 (HF: 1.00%). …”
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    Haplotype analysis of key genes governing grain yield and quality traits across 3K RG panel reveals scope for the development of tailor‐made rice with enhanced genetic gains
  16. 7656
    “…METHODS: We investigated the anti-proliferative efficacy of polar leaf extracts (LP), non-polar leaf extracts (LN), polar stem extract (SP) and non-polar stem extracts (SN) in human breast, colorectal, lung, endometrial, nasopharyngeal, and pancreatic cancer cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, MTT assay. …”
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    The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma
  17. 7657
    “…Clinical relapse and/or gadolinium-enhanced lesions (GEL) in MRI within 90 days from CSF collection by lumbar puncture (LP) were registered and considered as indicators of disease activity. …”
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    Combined Cerebrospinal Fluid Neurofilament Light Chain Protein and Chitinase-3 Like-1 Levels in Defining Disease Course and Prognosis in Multiple Sclerosis
  18. 7658
    “…BACKGROUND: MenB-FHbp (bivalent rLP2086), a meningococcal serogroup B vaccine, is approved in several countries for adolescents and young adults. …”
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    2722. Effects of Sex, Age, and Race on Immunogenicity of MenB-FHbp, a Bivalent Meningococcal B Vaccine: A Pooled Evaluation of Clinical Trial Data
  19. 7659
    “…The number of lymphocytic aggregates/field in the gut mucosa was higher in CC than in WSC (P = 0.019), in addition to those of the lamina propria (LP) eosinophils (P < 0.001) and fibroblasts (P < 0.001). …”
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    Cancer cachexia induces morphological and inflammatory changes in the intestinal mucosa
  20. 7660
    “…Total cholesterol (TC)/high density lipoprotein cholesterol (HDL-C) ratio and related variables; TC, HDL-C, low density lipoprotein cholesterol (LDL-C), TAG, apoA1, ApoB, ApoA1 (apolipoprotein A1)/ApoB (apolipoprotein B), lipoprotein (a) (Lp(a)), NEFA, LDL sub-fractions, were assessed pre- and post-intervention. …”
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    Fatty acid regio-specificity of triacylglycerol molecules may affect plasma lipid responses to dietary fats—a randomised controlled cross-over trial
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