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Mostrando 201 - 220 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.17s Limitar resultados
  1. 201
    “…BACKGROUND: CC‐90011 is an oral, potent, selective, reversible inhibitor of lysine‐specific demethylase 1 (LSD1) that was well tolerated, with encouraging activity in patients who had advanced solid tumors or relapsed/refractory marginal zone lymphoma. …”
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    Clinical activity of CC‐90011, an oral, potent, and reversible LSD1 inhibitor, in advanced malignancies
  2. 202
    por Li, Boao, Zhang, Xiangyu, Li, Jibin
    Publicado 2022
    “…Previously, inhibiting LSD1 has been found to be an effective treatment strategy for opposing tumors caused by overexpression of LSD1. …”
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    Carrier-free supramolecular nanoassemblies of pure LSD1 inhibitor for effective anti-tumor therapy
  3. 203
    por Silva, L., Bravo, L.
    Publicado 2022
    “…INTRODUCTION: Lysergic acid diethylamide (LSD) a semi synthetic hallucinogen, was first synthetized by Albert Hofmann in 1938 and its psychological properties were not discovered until 1943. …”
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    Does LSD Have Any Therapeutical Value In Mental Disorders? A Non-Systemic Review
  4. 204
    “…Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely H3K4me1/2 and H3K9me1/2, using FAD as the cofactor. …”
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    LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials
  5. 205
    por Jones, Andrew
    Publicado 2023
    “…Since reports about CIA-funded LSD studies came out in the 1970s, psychedelic drugs have invoked images of unethical experimentation and “mad scientists” in the public imagination. …”
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    Confronting the figure of the “mad scientist” in psychedelic history: LSD’s use as a correctional tool in the postwar period
  6. 206
    “…Psilocybin and lysergic acid diethylamide (LSD) experiences can range from very positive to highly challenging (e.g., fear, grief, and paranoia). …”
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    Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences
  7. 207
    “…Lysine-specific demethylase 1 (LSD1) is highly expressed in many cancer types and strongly associated with cancer progression and metastasis. …”
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    Vesicular Release and Uptake of Circular LSD1-RNAs from Non-Cancer and Cancer Lung Cells
  8. 208
    “…To enable expression of viral immediate early (IE) genes, both viruses use the cellular transcriptional coactivator HCF-1 to recruit the demethylase LSD1 to the viral immediate early promoters. Depletion of LSD1 or inhibition of its activity with MAO inhibitors results in the accumulation of repressive chromatin and a block to viral gene expression. …”
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    Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency
  9. 209
    “…The mRNA levels of LSD1 were detected by qRT-PCR. The correlation of LSD1 expression with clinical characteristics and prognosis was determined by statistical analysis. …”
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    Over-Expression of LSD1 Promotes Proliferation, Migration and Invasion in Non-Small Cell Lung Cancer
  10. 210
    “…Using, clorgyline, an LSD1 inhibitor (LSD1i) to treat cancer cell lines, we show that clorgyline employs two mechanisms of action depending on the cell type: it can either induce global DNA demethylation or inhibit LSD1-driven H3K4me2 and H3K4me1 demethylation to establish an active chromatin configuration. …”
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    Synergistic Re-Activation of Epigenetically Silenced Genes by Combinatorial Inhibition of DNMTs and LSD1 in Cancer Cells
  11. 211
    “…Transcription activator–like (TAL) effector repeat domains fused to the LSD1 histone demethylase efficiently remove enhancer-associated chromatin modifications from target loci, without affecting control regions. …”
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    Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions
  12. 212
    “…Lysine-specific demethylase 1 (LSD1) was shown to control gene expression and cell proliferation of androgen-dependent prostate cancer (PCa) cells, whereas the role of LSD1 in androgen-independent metastatic prostate cancer remains elusive. …”
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    LSD1 controls metastasis of androgen-independent prostate cancer cells through PXN and LPAR6
  13. 213
    “…LSD1, a lysine-specific histone demethylase, is overexpressed in several types of cancers and linked to poor outcomes. …”
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    LSD1 Overexpression Is Associated with Poor Prognosis in Basal-Like Breast Cancer, and Sensitivity to PARP Inhibition
  14. 214
    por Chai, Tingting, Zhou, Jun, Liu, Jian, Xing, Da
    Publicado 2015
    “…Under RL, the lsd1 mutant released more ROS and SA and displayed a stronger cell death rate than the hy5 mutant. …”
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    LSD1 and HY5 antagonistically regulate red light induced-programmed cell death in Arabidopsis
  15. 215
    “…LSD1 is a histone lysine demethylase, which is highly expressed in multiple types of human cancer. …”
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    SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells
  16. 216
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    Corrigendum: LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice
  17. 217
    “…Surprisingly, ERα engages not only LSD1, but its partners of the CoREST corepressor complex and the molecular chaperone Hsp90. …”
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    LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP
  18. 218
    “…ZNF516 is physically associated with the CtBP/LSD1/CoREST complex and transcriptionally represses a cohort of genes including EGFR that are critically involved in cell proliferation and motility. …”
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    ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
  19. 219
    “…Lysine-specific demethylase 1 (LSD1) – also known as KDM1A – is the first identified histone demethylase. …”
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    Lysine-specific demethylase 1 (LSD1) destabilizes p62 and inhibits autophagy in gynecologic malignancies
  20. 220
    “…In the present study, we determine that two different LSD1 inhibitors (TCP and SP2509) as well as selective ablation of LSD1 expression promote autophagy in neuroblastoma cells. …”
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    Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway
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