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201por Hollebecque, Antoine, Salvagni, Stefania, Plummer, Ruth, Niccoli, Patricia, Capdevila, Jaume, Curigliano, Giuseppe, Moreno, Victor, de Braud, Filippo, de Villambrosia, Sonia Gonzalez, Martin‐Romano, Patricia, Baudin, Eric, Arias, Marina, de Alvaro, Juan, Parra‐Palau, Josep L., Sánchez‐Pérez, Tania, Aronchik, Ida, Filvaroff, Ellen H., Lamba, Manisha, Nikolova, Zariana, de Bono, Johann S.“…BACKGROUND: CC‐90011 is an oral, potent, selective, reversible inhibitor of lysine‐specific demethylase 1 (LSD1) that was well tolerated, with encouraging activity in patients who had advanced solid tumors or relapsed/refractory marginal zone lymphoma. …”
Publicado 2022
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202“…Previously, inhibiting LSD1 has been found to be an effective treatment strategy for opposing tumors caused by overexpression of LSD1. …”
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203“…INTRODUCTION: Lysergic acid diethylamide (LSD) a semi synthetic hallucinogen, was first synthetized by Albert Hofmann in 1938 and its psychological properties were not discovered until 1943. …”
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204“…Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely H3K4me1/2 and H3K9me1/2, using FAD as the cofactor. …”
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205por Jones, Andrew“…Since reports about CIA-funded LSD studies came out in the 1970s, psychedelic drugs have invoked images of unethical experimentation and “mad scientists” in the public imagination. …”
Publicado 2023
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206por Zeifman, Richard J., Kettner, Hannes, Pagni, Broc A., Mallard, Austin, Roberts, Daniel E., Erritzoe, David, Ross, Stephen, Carhart-Harris, Robin L.“…Psilocybin and lysergic acid diethylamide (LSD) experiences can range from very positive to highly challenging (e.g., fear, grief, and paranoia). …”
Publicado 2023
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207por Galang, Joelle Noriko, Shen, Yefeng, Koitzsch, Ulrike, Yu, Xiaojie, Eischeid-Scholz, Hannah, Bachurski, Daniel, Rau, Tilman T., Neppl, Christina, Herling, Marco, Bulimaga, Bianca, Vasyutina, Elena, Schweiger, Michal R., Büttner, Reinhard, Odenthal, Margarete, Anokhina, Maria M.“…Lysine-specific demethylase 1 (LSD1) is highly expressed in many cancer types and strongly associated with cancer progression and metastasis. …”
Publicado 2023
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208“…To enable expression of viral immediate early (IE) genes, both viruses use the cellular transcriptional coactivator HCF-1 to recruit the demethylase LSD1 to the viral immediate early promoters. Depletion of LSD1 or inhibition of its activity with MAO inhibitors results in the accumulation of repressive chromatin and a block to viral gene expression. …”
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209Over-Expression of LSD1 Promotes Proliferation, Migration and Invasion in Non-Small Cell Lung Cancerpor Lv, Tangfeng, Yuan, Dongmei, Miao, Xiaohui, Lv, Yanling, Zhan, Ping, Shen, Xiaokun, Song, Yong“…The mRNA levels of LSD1 were detected by qRT-PCR. The correlation of LSD1 expression with clinical characteristics and prognosis was determined by statistical analysis. …”
Publicado 2012
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210“…Using, clorgyline, an LSD1 inhibitor (LSD1i) to treat cancer cell lines, we show that clorgyline employs two mechanisms of action depending on the cell type: it can either induce global DNA demethylation or inhibit LSD1-driven H3K4me2 and H3K4me1 demethylation to establish an active chromatin configuration. …”
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211por Mendenhall, Eric M., Williamson, Kaylyn E., Reyon, Deepak, Zou, James Y., Ram, Oren, Joung, J. Keith, Bernstein, Bradley E.“…Transcription activator–like (TAL) effector repeat domains fused to the LSD1 histone demethylase efficiently remove enhancer-associated chromatin modifications from target loci, without affecting control regions. …”
Publicado 2013
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212por Ketscher, A, Jilg, C A, Willmann, D, Hummel, B, Imhof, A, Rüsseler, V, Hölz, S, Metzger, E, Müller, J M, Schüle, R“…Lysine-specific demethylase 1 (LSD1) was shown to control gene expression and cell proliferation of androgen-dependent prostate cancer (PCa) cells, whereas the role of LSD1 in androgen-independent metastatic prostate cancer remains elusive. …”
Publicado 2014
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213por Nagasawa, Satoi, Sedukhina, Anna S., Nakagawa, Yuko, Maeda, Ichiro, Kubota, Manabu, Ohnuma, Shigeko, Tsugawa, Koichiro, Ohta, Tomohiko, Roche-Molina, Marta, Bernal, Juan A., Narváez, Ana J., Jeyasekharan, Anand D., Sato, Ko“…LSD1, a lysine-specific histone demethylase, is overexpressed in several types of cancers and linked to poor outcomes. …”
Publicado 2015
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214“…Under RL, the lsd1 mutant released more ROS and SA and displayed a stronger cell death rate than the hy5 mutant. …”
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215por Piao, Lianhua, Suzuki, Takehiro, Dohmae, Naoshi, Nakamura, Yusuke, Hamamoto, Ryuji“…LSD1 is a histone lysine demethylase, which is highly expressed in multiple types of human cancer. …”
Publicado 2015
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216por Kim, Jeesun, Singh, Anup Kumar, Takata, Yoko, Lin, Kevin, Shen, Jianjun, Lu, Yue, Kerenyi, Marc A., Orkin, Stuart H., Chen, TaipingEnlace del recurso
Publicado 2016
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217“…Surprisingly, ERα engages not only LSD1, but its partners of the CoREST corepressor complex and the molecular chaperone Hsp90. …”
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218por Li, Lifang, Liu, Xinhua, He, Lin, Yang, Jianguo, Pei, Fei, Li, Wanjin, Liu, Shumeng, Chen, Zhe, Xie, Guojia, Xu, Bosen, Ting, Xia, Zhang, Zihan, Jin, Tong, Liu, Xujun, Zhang, Wenting, Yuan, Shuai, Yang, Ziran, Wu, Chongyang, Zhang, Yu, Yang, Xiaohan, Yi, Xia, Liang, Jing, Shang, Yongfeng, Sun, Luyang“…ZNF516 is physically associated with the CtBP/LSD1/CoREST complex and transcriptionally represses a cohort of genes including EGFR that are critically involved in cell proliferation and motility. …”
Publicado 2017
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219por Chao, Angel, Lin, Chiao-Yun, Chao, An-Ning, Tsai, Chia-Lung, Chen, Ming-Yu, Lee, Li-Yu, Chang, Ting-Chang, Wang, Tzu-Hao, Lai, Chyong-Huey, Wang, Hsin-Shih“…Lysine-specific demethylase 1 (LSD1) – also known as KDM1A – is the first identified histone demethylase. …”
Publicado 2017
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220“…In the present study, we determine that two different LSD1 inhibitors (TCP and SP2509) as well as selective ablation of LSD1 expression promote autophagy in neuroblastoma cells. …”
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