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Mostrando 221 - 240 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.18s Limitar resultados
  1. 221
    “…Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. …”
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    Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD
  2. 222
    “…Overall, our data suggest that CACUL1 tightly regulates PPARγ signaling through the mutual opposition between SIRT1 and LSD1, providing insight into its potential use for anti-obesity treatment.…”
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    CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis
  3. 223
    “…However, how are the LSD1-TF and, in particular LSD1-ERRα, complexes determined to act at TSSs is not understood. …”
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    LSD1-ERRα complex requires NRF1 to positively regulate transcription and cell invasion
  4. 224
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    LSD1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells
  5. 225
    “…As such, this study investigated Ewing sarcoma mechanisms of acquired resistance to the small molecule reversible lysine specific demethylase (LSD1/KDM1A) inhibitor SP-2509. Surprisingly, whole exome sequencing analysis of our generated A673 SP-2509 drug resistant cell line revealed an absence of mutations in KDM1A. …”
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    Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation
  6. 226
    “…In the androgen-sensitive cell lines, AR knockdown attenuated sensitivity to the LSD1 inhibitor but not the JQ1 inhibitor. Strikingly, treatment with SP-2509 slightly, and JQ1 markedly increased invasion in PCa cells with high AR expression but decreased invasion in PCa cells with low/negative AR expression. …”
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    The combined effect of epigenetic inhibitors for LSD1 and BRD4 alters prostate cancer growth and invasion
  7. 227
    “…AIMS: KDM1A/LSD1 and ZNF217 are involved in a protein complex that participates in transcriptional regulation. …”
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    Somatic deletion of KDM1A/LSD1 gene is associated to advanced colorectal cancer stages
  8. 228
    “…LSD was well tolerated, and the frequency of adverse events was no higher than for placebo. …”
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    Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers
  9. 229
    “…This study aims to explore the role of LSD1 in directed differentiation of human embryonic stem cells into insulin-producing cells. …”
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    LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells
  10. 230
    “…We propose a new strategy to acquire insulin-producing cells (IPCs) from hiPSCs by knocking down LSD1. METHODS: Knockdown of LSD1 in hiPSCs with five shRNA. …”
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    Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells
  11. 231
    “…LSD increases social adaptation but only if the opinions of others are similar to the individual’s own. …”
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    LSD-induced increases in social adaptation to opinions similar to one’s own are associated with stimulation of serotonin receptors
  12. 232
    “…BACKGROUND: Lysine-specific histone demethylase 1 (LSD1) is a potential target of cancer therapy. In the present study, we aimed to investigate the combined antitumor activity of a novel LSD1 inhibitor (ZY0511) with 5-fluorouracil (5-FU) and elucidate the underlying mechanism in colorectal cancer (CRC). …”
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    Synergistic antitumor effect of 5-fluorouracil with the novel LSD1 inhibitor ZY0511 in colorectal cancer
  13. 233
    “…Lysine specific demethylase-1 (LSD1) has been shown to be critical in acute myeloid leukemia (AML) pathogenesis and this has led to the development of LSD1 inhibitors (LSD1i) which are currently tested in clinical trials. …”
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    Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition
  14. 234
    “…To rescue impaired CD141(Hi) cDC differentiation, we used pharmacologic inhibition of lysine-specific demethylase 1A (LSD1) to promote CD141(Hi) cDC differentiation by MDS progenitors. …”
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    Inhibition of LSD1 in MDS Progenitors Restores Differentiation of CD141(Hi) Conventional Dendritic Cells
  15. 235
    “…Herein, we uncover new mechanisms of the histone demethylase LSD1, and various inhibitors targeting unique domains of LSD1, in the function of NK cells grown for cell therapy. …”
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    Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione
  16. 236
    “…Acute LSD (30 μg/kg) injection failed to increase SB. …”
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    Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission
  17. 237
    por Qin, Xu-ke, Du, Yang, Liu, Xiu-heng, Wang, Lei
    Publicado 2021
    “…Moreover, exogenous wild type LSD1 and catalytically deficient mutant K661A both can abrogate previous effect of LSD1 knock-down. …”
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    LSD1 Promotes Prostate Cancer Cell Survival by Destabilizing FBXW7 at Post-Translational Level
  18. 238
    “…Whole blood samples were collected for TBPs and viral (LSD and FMD) examinations, while tissue specimens were collected for detection of FMD and LSD viruses by real-time PCR. …”
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    Prevalence of tick-borne haemoparasites and their perceived co-occurrences with viral outbreaks of FMD and LSD and their associated factors
  19. 239
    “…METHOD: A cross-sectional survey study among psilocybin and LSD users. Respondents (n=1661; M(age)=22.9, standard deviation=8.5; Caucasian/White=83%; non-Hispanic=91%; men=72%; United States resident=66%) completed an Internet-based survey. …”
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    Development of the Psychological Insight Questionnaire among a sample of people who have consumed psilocybin or LSD
  20. 240
    “…The lsd1 mutant, lacking functional LSD1 protein, accumulates SA and is conditionally susceptible to many biotic and abiotic stresses. …”
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    Salicylic Acid Accumulation Controlled by LSD1 Is Essential in Triggering Cell Death in Response to Abiotic Stress
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