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Mostrando 261 - 280 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.15s Limitar resultados
  1. 261
    “…However, there has been no published research on the effect of LSD on alcohol consumption in animals. This study evaluated the effect of LSD in mice using a two-bottle choice alcohol drinking paradigm. …”
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    LSD Administered as a Single Dose Reduces Alcohol Consumption in C57BL/6J Mice
  2. 262
    “…We found that SP2509, a selective inhibitor of LSD1, specifically promoted the differentiation of Utx-null HSPCs while sparing wild-type HSPCs. …”
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    Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy
  3. 263
    por Yabuta, Suemi, Shidoji, Yoshihiro
    Publicado 2019
    “…AIM: Histone-modifiable lysine-specific demethylase-1 (LSD1/KDM1A) is an oncoprotein upregulated in cancers, including hepatoma. …”
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    Cytoplasmic translocation of nuclear LSD1 (KDM1A) in human hepatoma cells is induced by its inhibitors
  4. 264
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    Author Correction: LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer
  5. 265
    “…Lysine specific demethylase 1 (LSD1/KDM1A) plays a well-established role in the normal hematopoietic and neuronal stem cells. …”
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    LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target
  6. 266
    “…Our results show that the relatively higher level of LSD1 in fetal ovaries sharply reduces from 18.5 postcoitus (dpc). …”
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    LSD1 contributes to programmed oocyte death by regulating the transcription of autophagy adaptor SQSTM1/p62
  7. 267
    “…Furthermore, prolonged RA exposure phenocopies LSD1 inhibition, suggesting that LSD1 regulates endocrine cell differentiation by limiting the duration of RA signalling. …”
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    LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
  8. 268
    “…The DRED complex contains the epigenetic eraser lysine-specific demethylase 1 (LSD1), which appears to serve as a scaffolding protein. …”
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    Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease
  9. 269
    “…LSD1 inhibition reduces growth of MCC in vitro and in vivo. …”
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    Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis
  10. 270
    “…Moreover, our results illustrated that LSD1 diminished the enrichment of H3K4me2 at the SESN2 promoter. …”
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    HDAC1‐mediated deacetylation of LSD1 regulates vascular calcification by promoting autophagy in chronic renal failure
  11. 271
    “…Lysergic acid diethylamide (LSD) is a classic psychedelic substance that is used recreationally and investigated in psychiatric research. …”
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    Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis
  12. 272
    “…Therefore, the main aim of our study was to assess the effects of tryptamine and phenethylamine psychedelics (psilocin 4 mg/kg, LSD 0.2 mg/kg, mescaline 100 mg/kg, and DOB 5 mg/kg) on EEG in freely moving rats. …”
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    Psilocin, LSD, mescaline, and DOB all induce broadband desynchronization of EEG and disconnection in rats with robust translational validity
  13. 273
    “…Lysine-specific demethylase 1 (LSD1) is an epigenetic regulator that modulates the chromatin status, contributing to gene activation or repression. …”
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    LSD1-S112A exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice
  14. 274
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    Author Correction: LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade
  15. 275
    “…LSD and CBPP are both transboundary diseases spreading in the same areas of Africa and Asia. …”
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    Development and Evaluation of a Combined Contagious Bovine Pleuropneumonia (CBPP) and Lumpy Skin Disease (LSD) Live Vaccine
  16. 276
    “…PURPOSE: To study the role of lysine-specific demethylase 1 (LSD1) in retinoblastoma (RB) growth and to determine whether the LSD1 inhibitor SP2509 can inhibit RB progression. …”
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    SP2509, a Selective Inhibitor of LSD1, Suppresses Retinoblastoma Growth by Downregulating β-catenin Signaling
  17. 277
    “…Here we visualized the nuclear complex of Snail and LSD1 as foci signals using proximity ligation assay. …”
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    Dexamethasone resets stable association of nuclear Snail with LSD1 concomitant with transition from EMT to partial EMT
  18. 278
    “…CoIP, GST-pulldown, ChIP, Re-ChIP, qPCR and Immunoblot were used to investigate the underlying mechanism of Slug-PRMT5-LSD1 complex. The role of PRMT5 and LSD1 in breast cancer progression was evaluated both in vivo and in vitro. …”
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    The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression
  19. 279
    “…We were surprised to find that traditional catalytic LSD1 inhibitors had minimal effect in isolation and did not seem to synergize with HDAC inhibitors, while a recently described CoREST/LSD1 degrader named UM171 phenocopied the effects seen in our CRISPR screen. …”
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    DIPG-26. Targeted Protein Degradation of LSD1 synergizes with HDAC inhibitors in Diffuse Intrinsic Pontine Glioma
  20. 280
    “…Given the capacity of UM171a to trigger APC-like function in MSCs, and the recent finding that this drug may modulate the epigenome by inhibiting the lysine-specific demethylase 1 (LSD1), we explored whether the direct pharmacological inhibition of LSD1 could instill APC-like functions in MSCs akin to UM171a. …”
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    LSD1 Inhibition Enhances the Immunogenicity of Mesenchymal Stromal Cells by Eliciting a dsRNA Stress Response
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